Addressing the health needs of a growing and ageing population is a central challenge facing modern society. Technology is enabling the collection of increasingly large and heterogeneous biomedical data sets, yet interpreting such data to gain knowledge about disease mechanisms and clinical and preventative strategies is still a major open problem. Artificial Intelligence (AI) techniques hold huge promise to provide an integrative framework for extracting knowledge from data, with a high potential for fundamental and clinical breakthroughs with significant impact both on public health and on the future of the UK bioeconomy. The ambition of the proposed CDT is to train a cadre of highly skilled interdisciplinary scientists who will spearhead the development and deployment of AI techniques in the biomedical sector. Achieving our long-term aims will require several hurdles to be overcome. The biomedical sector poses unique methodological challenges to AI technology, due to the need of interpretable models which can quantify uncertainties within predictions. It also presents formidable cultural and technical language barriers, requiring honed communication skills to overcome disciplinary boundaries. Perhaps most importantly, it requires researchers and practitioners with a keen awareness of the societal, legal and ethical dimension of their research, who are able to reach out to societal stakeholders, and to anticipate and engage with the potential issues arising from deploying AI technology in the biomedical sector. We will realise our ambition through a structured training programme: students will initially acquire the foundational skills in a Master by Research first year, which includes taught courses on the technical, biomedical and socio-ethical aspects of biomedical AI, and provides multiple opportunities to directly experience interdisciplinary research through rotation projects. Students will then acquire in depth research experience through an interdisciplinary PhD, bridging between the University of Edinburgh's world-leading institutions pursuing informatics and biomedical research. Students will benefit from a large and exceptionally distinguished faculty of potential supervisors: over 60 academics including several fellows of the Royal Society/ Royal Society of Edinburgh, and over forty recipients of prestigious fellowships from the ERC, the research councils, and biomedical charities such as the Wellcome Trust. This training programme will be interleaved with intensive training in interdisciplinary communication and science communication, and will offer multiple opportunities to engage with external stakeholders including industrial and NHS internships.

How can we trust autonomous computer-based systems? Autonomous means "independent and having the power to make your own decisions". This proposal tackles the issue of trusting autonomous systems (AS) by building: experience of regulatory structure and practice, notions of cause, responsibility and liability, and tools to create evidence of trustworthiness into modern development practice. Modern development practice includes continuous integration and continuous delivery. These practices allow continuous gathering of operational experience, its amplification through the use of simulators, and the folding of that experience into development decisions. This, combined with notions of anticipatory regulation and incremental trust building form the basis for new practice in the development of autonomous systems where regulation, systems, and evidence of dependable behaviour co-evolve incrementally to support our trust in systems. This proposal is in consortium with a multi-disciplinary team from Edinburgh, Heriot-Watt, Glasgow, KCL, Nottingham and Sussex, bringing together computer science and AI specialists, legal scholars, AI ethicists, as well as experts in science and technology studies and design ethnography. Together, we present a novel software engineering and governance methodology that includes: 1) New frameworks that help bridge gaps between legal and ethical principles (including emerging questions around privacy, fairness, accountability and transparency) and an autonomous systems design process that entails rapid iterations driven by emerging technologies (including, e.g. machine learning in-the-loop decision making systems) 2) New tools for an ecosystem of regulators, developers and trusted third parties to address not only functionality or correctness (the focus of many other Nodes) but also questions of how systems fail, and how one can manage evidence associated with this to facilitate better governance. 3) Evidence base from full-cycle case studies of taking AS through regulatory processes, as experienced by our partners, to facilitate policy discussion regarding reflexive regulation practices.

We propose a Centre for Doctoral Training in Integrative Sensing and Measurement that addresses the unmet UK need for specialist training in innovative sensing and measurement systems identified by EPSRC priorities the TSB and EPOSS . The proposed CDT will benefit from the strategic, targeted investment of >£20M by the partners in enhancing sensing and measurement research capability and by alignment with the complementary, industry-focused Innovation Centre in Sensor and Imaging Systems (CENSIS). This investment provides both the breadth and depth required to provide high quality cohort-based training in sensing across the sciences, medicine and engineering and into the myriad of sensing applications, whilst ensuring PhD supervision by well-resourced internationally leading academics with a passion for sensor science and technology. The synergistic partnership of GU and UoE with their active sensors-related research collaborations with over 160 companies provides a unique research excellence and capability to provide a dynamic and innovative research programme in sensing and measurement to fuel the development pipeline from initial concept to industrial exploitation.

In a consortium led by Heriot-Watt with St Andrews, Glasgow, Strathclyde and Dundee, this proposal is for an EPSRC CDT in Applied Photonics and responds to the Integrative Technologies priority area, but also impacts on the Measurement and Sensing, Photonic Materials and Innovative Production Processes priorities. Technologies integrating photonics and electronics pervade products and services in any modern economy, enabling vital activities in manufacturing, security, telecommunications, healthcare, retail, entertainment and transport. The success of UK companies in this technology space is threatened by a lack of doctoral-level researchers with a grasp of photonic- / electronic-engineering design, fabrication and systems integration, coupled with high-level business, management and communication skills. By ensuring a supply of these individuals, our CDT will deliver broad-ranging impacts on the UK industrial knowledge base, driving the high-growth export-led sectors of the UK economy whose photonics-enabled products and services have far-reaching impacts on society, from consumer technology and mobile computing devices to healthcare and security. Building on the success of our current IDC in Optics and Photonics Technologies, the proposed CDT will again be configured as an IDC but will enhance our existing programme to meet industry's need for engineers able to integrate photonic and electronic devices, circuits and systems to deliver high value products and processes. Our proposal was developed in partnership with industry, whose letters of support show a commitment to sponsoring 71-74 EngD and 14-17 PhD projects -- 40% more than the minimum required -- demonstrating exceptional industrial engagement. Major stakeholders include Fraunhofer UK, NPL, Renishaw, Thales, BAE Systems, Gooch and Housego and Selex ES, who are joined by a number of SMEs. The CDT follows a model in which (annually) EPSRC funds 7 EngD students, with 3 more supported by industrial / university contributions. In a progressive strategy supported by our industrial partners, we will, where appropriate, align university-funded PhD projects to the programme to leverage greater industry engagement with PhD research in the consortium. The focus of the CDT corresponds to areas of research excellence in the consortium, which comprises 89 academic supervisors, whose papers since 2008 total 584 in all optics journals , with 111 in Science / Nature / PRL, and whose active EPSRC PI photonics funding is £40.9M. All academics are experienced supervisors, having each supervised on average >6 doctoral students, with many previously acting as IDC supervisors. The strategic commitment by the participating universities is evidenced by their recruitment since 2008 of 29 new academic staff in relevant areas (including 9 professors). An 8-month frontloaded residential phase in St Andrews and Glasgow will ensure the cohort strongly gels together, and will equip students with the technical knowledge and skills they need before they begin their industrial research project. Business modules (x3) will bring each cohort back to Heriot-Watt for 1-week periods, and weekend skills workshops will be used to regularly reunite the cohort, further consolidating it to create opportunities for peer-to-peer interactions. Taught courses will total 120 credits, and will be supplemented by new Computational Methods, Systems Integration and Research Skills workshops delivered by our industry partners, as well as public-engagement training led by Glasgow Science Centre. Another innovation is an International Advisory Board, comprising leading academics / industrialists , who will benchmark and advise on our performance. The requested EPSRC support of £4.5M is complemented by £2.8M of industrial / academic cash, covering the cost of 3 students in each cohort of 10. In-kind industrial / academic contributions are worth a further £5.4M, providing exceptional value.

In a consortium led by Heriot-Watt with St Andrews, Glasgow, Strathclyde, Edinburgh and Dundee, this proposal for an "EPSRC CDT in Industry-Inspired Photonic Imaging, Sensing and Analysis" responds to the priority area in Imaging, Sensing and Analysis. It recognises the foundational role of photonics in many imaging and sensing technologies, while also noting the exciting opportunities to enhance their performance using emerging computational techniques like machine learning. Photonics' role in sensing and imaging is hard to overstate. Smart and autonomous systems are driving growth in lasers for automotive lidar and smartphone gesture recognition; photonic structural-health monitoring protects our road, rail, air and energy infrastructure; and spectroscopy continues to find new applications from identifying forgeries to detecting chemical-warfare agents. UK photonics companies addressing the sensing and imaging market are vital to our economy (see CfS) but their success is threatened by a lack of doctoral-level researchers with a breadth of knowledge and understanding of photonic imaging, sensing and analysis, coupled with high-level business, management and communication skills. By ensuring a supply of these individuals, our CDT will consolidate the UK industrial knowledge base, driving the high-growth export-led sectors of the economy whose photonics-enabled products and services have far-reaching impacts on society, from consumer technology and mobile computing devices to healthcare and security. Building on the success of our CDT in Applied Photonics, the proposed CDT will be configured with most (40) students pursuing an EngD degree, characterised by a research project originated by a company and hosted on their site. Recognizing that companies' interests span all technology readiness levels, we are introducing a PhD stream where some (15) students will pursue industrially relevant research in university labs, with more flexibility and technical risk than would be possible in an EngD project. Overwhelming industry commitment for over 100 projects represents a nearly 100% industrial oversubscription, with £4.38M cash and £5.56M in-kind support offered by major stakeholders including Fraunhofer UK, NPL, Renishaw, Thales, Gooch and Housego and Leonardo, as well as a number of SMEs. Our request to EPSRC for £4.86M will support 35 students, from a total of 40 EngD and 15 PhD researchers. The remaining students will be funded by industrial (£2.3M) and university (£0.93M) contributions, giving an exceptional 2:3 cash gearing of EPSRC funding, with more students trained and at a lower cost / head to the taxpayer than in our current CDT. For our centre to be reactive to industry's needs a diverse pool of supervisors is required. Across the consortium we have identified 72 core supervisors and a further 58 available for project supervision, whose 1679 papers since 2013 include 154 in Science / Nature / PRL, and whose active RCUK PI funding is £97M. All academics are experienced supervisors, with many current or former CDT supervisors. An 8-month frontloaded residential phase in St Andrews and Edinburgh will ensure the cohort gels strongly, and will equip students with the knowledge and skills they need before beginning their research projects. Business modules (x3) will bring each cohort back to Heriot-Watt for 1-week periods, and weekend skills workshops will be used to regularly reunite the cohort, further consolidating the peer-to-peer network. Core taught courses augmented with specialist options will total 120 credits, and will be supplemented by professional skills and responsible innovation training delivered by our industry partners and external providers. Governance will follow our current model, with a mixed academic-industry Management Committee and an independent International Advisory Board of world-leading experts.