Campylobacter spp. are extremely important food borne enteropathogenic bacteria, estimated to cause over 600,000 cases of infection in the UK each year with around 100 deaths. It is estimated that Campylobacter infections cost the UK economy around £1 billion per year. Infection is characterised by acute and sometimes bloody diarrhoea, particularly in children. The last few years have seen a marked rise in cases in compromised elderly populations and in such people, particularly those with bowel cancer, infection can be fatal. Chicken meat is the most important source and vehicle for human Campylobacter infections and around 80% of chickens on sale in the UK are Campylobacter-positive. Campylobacter are natural inhabitants of the intestinal tract of chickens and other food animals. Contamination of chicken meat takes two forms. Carcass surfaces can carry high levels of Campylobacter and this can lead to cross-contamination in both domestic and commercial catering. This is an important risk factor for infection. However, and perhaps more importantly, Campylobacter have been recovered from deep muscle tissues of up to 27% of chickens tested. Furthermore, liver tissues are also commonly contaminated. In these tissues the bacteria will be better protected from the effects of cooking. Undercooked chicken meat and chicken liver pate are internationally important vehicles of Campylobacter infection. To improve public health in the UK it is essential that the number of contaminated chickens on sale is reduced. The proposed research will examine the different systems in which UK chickens are grown to identify cost-effective farm-based control options. Our work will focus on chickens reared intensively in housed systems as these comprise ~90% of the UK market. The work will be in collaboration with the three biggest poultry producers in the UK and all the major UK food retailers are giving financial support. The proposed research builds on past studies which showed that chickens (broilers) reared under higher welfare systems are less likely to have Campylobacter than birds reared more intensively. The higher welfare systems generally use slower-growing birds and stock houses with fewer birds than the more intensive systems. Our work showed that birds reared in the more intensive system had poorer welfare, as shown by high rates of endemic disease and general health and leg problems. This might explain why these birds were more likely to be Campylobacter-positive, as birds compromised by poor health and/or welfare are more susceptible to these bacteria. These differences might be due to the birds used and/or the in-house environment and we will determine this. Our field work might also indicate that the slower-growing bird types may be inherently more Campylobacter-resistant. We will conduct longitudinal studies on flocks reared under different systems and determine when birds first become Campylobacter-positive and relate this to changes in bird health and welfare. We will also determine whether the spread of Campylobacter from the intestine of the birds to edible tissues like liver occurs on farm and if it is linked to poor welfare for endemic disease. Our aim is to provide the UK poultry industry with science-based and cost-effective control options, which will help it meet customer demands and comply with forth-coming EU legislation aimed at reducing the number of chickens that are Campylobacter-positive.

The UK food chain, comprising agricultural production, manufacturing, distribution, retail and consumption, involves more than 300,000 enterprises and employs 3.6 million people. The food and drink industry is the largest manufacturing sector, employing 500,000 people and contributing £80 billion to the economy. It is also estimated that the food chain is responsible for 160 MtCO2e emissions and 15 Mt of food waste, causing significant environmental impacts. Energy is an important input in all stages of the food chain and is responsible for 18% of the UK's final energy demand. In recent years, progress has been made in the reduction of energy consumption and emissions from the food chain primarily through the application of well proven technologies that could lead to quick return on investment. To make further progress, however, significant innovations will have to be made in approaches and technologies at all stages of the food chain, taking a holistic view of the chain and the interactions both within the chain and the external environment. The EPSRC Centre for Sustainable Energy Use in Food Chains will make significant contributions in this field. It will bring together multidisciplinary research groups of substantial complementary experience and internationally leading research track record from the Universities of Brunel, Manchester and Birmingham and a large number of key stakeholders to investigate and develop innovative approaches and technologies to effect substantial end use energy demand reductions. The Centre will engage both in cutting edge research into approaches and technologies that will have significant impacts in the future, leading towards the target of 80% reduction in CO2 emissions by 2050, but also into research that will have demonstrable impacts within the initial five year lifetime of the Centre. Taking a whole systems approach, the research themes will involve: i) Simulation of energy and resource flows in the food chain, from farm-gate to plate to enable investigations of energy and resource flows between the stages of the chain and the external environment, and facilitate overall energy and resource use optimisation taking into consideration the impact of policy decisions, future food and energy prices and food consumption trends. ii) Investigation of approaches and technologies for the reduction of energy use at all stages of the chain through reduction of the energy intensity of individual processes and optimisation of resource use. It is expected that a number of new innovative and more efficient technologies and approaches for energy reduction will be developed in the lifetime of the Centre to address processing, distribution, retail and final consumption in the home and the service sector. iii) Identification of optimal ways of interaction between the food chain and the UK energy supply system to help manage varying demand and supply through distributed power generation and demand-response services to the grid. iv) Study of consumer behaviour and the impact of key influencing factors such as changing demographics, increased awareness of the needs and requirements of sustainable living, economic factors and consumption trends on the nature and structure of the food chain and energy use. Even though the focus will be on the food chain, many of the approaches and technologies developed will also be applicable to other sectors of the economy such as industry, commercial and industrial buildings and transportation of goods. The Centre will involve extensive collaboration with the user community, manufacturers of technology, Government Departments, Food Associations and other relevant research groups and networks. A key vehicle for dissemination and impact will be a Food Energy and Resource Network which will organise regular meetings and annual international conferences to disseminate the scientific outputs and engage the national and international research and user communities