In spite of the huge number of pathogens and diseases, the number of “transmission channels” or “transport routes” for microorganisms to enter in a farm or any other Farm2Fork facility is indeed limited to just nine. Tracing or monitoring transport of a single or a few microorganisms using a particular channel will provide valuable information on the channel itself and therefore on the transport effectiveness for the whole set of microorganisms using that particular channel. HE-FARM will develop and validate a methodology -based on experimental assays and tests in lab & operational env- to assess and predict transport-channel resolved biosecurity and simultaneously increase maturity of several disruptive novel techs. A software/APP will be created to help with these procedures and proposed as a draft for a future EN standard. Prototypes of novel technologies for biosecurity will additionally be developed and validated in operational environment -including extensive and intensive cow, pig, chicken, turkey, sheep and snail farms, a slaughter and meat preparation plant and trucks: Fast Integrated air-borne virus smart detector (PRRS and Avian Flue but easily extendable to other virus with an enormous like African Swine Fever whose early detection in air in minutes will have an enormous impact) Sanitization by low-toxicity biocides & dynamic aggregation. Low-toxicity insecticides & repellents & dynamic aggregation application & Env-Friendly Insect and Arachnids barrier and prevention techs. Rapid Vehicle decon. station. Biosecure & Env-Friendly Hall & Heat Venting and Cooling. Portable Low-cost test-device for fast measuring microbiological metabolism. Cold plasma farm water sanitization. Usage and training procedures and manuals & assessment of performance method. Finally at least other 3 biosecure techs externally provided selected in an open call will be experimentally tested. Comm. & dissemination include liaising with authorities like EFSA and OIE.

Farmed seafood is an important source of protein for food and feeds with a low-carbon footprint which has an important role to play in helping to build a sustainable food system. A strategic and long-term approach for the sustainable growth of a resilient EU aquaculture is, therefore, more relevant today than ever. However, the efficient and cost-effective control of pathogens remains among the main challenges for the sector, particularly relevant for Europe, where there is a great variety of species and production systems, which hinders the implementation of good husbandry practices tailored to each aquatic species. Through active engagement with key stakeholders, Cure4Aqua aims to jointly improve the resilience of EU aquaculture under environmental, biological, and socio-economic stress, by improving aquatic animal health and welfare and supporting the environmentally friendly, inclusive, safe, and healthy production of seafood. Cure4Aqua will do so by 1) developing cost-effective vaccines to prevent disease caused by 5 pathogens of economic significance to EU aquaculture; 2) Identifying markers with diagnostic capacity to be integrated to selective breeding programs to improve stress and disease management; 3) Developing innovative, bio-based and sustainable solutions as an alternative to antibiotics for controlling fish pathogens at various life stages and alleviate the pressure of global antimicrobial resistance; 4) Developing new tools and technology to improve health and welfare monitoring at the fish farm level and diagnostics of fish pathogens both at the laboratory and the fish farm levels; 5) Placing fish welfare at the foreground of aquaculture production, through the development of high welfare standards that consider different life-stages, production systems, and knowledge of welfare needs, and 6) Ensuring effective external communication, dissemination and exploitation of project activities and results to all relevant target groups.

2D-BioPAD is a cost-effective, non-invasive point of care/self-testing tool for the early and accurate prognosis (assistive diagnosis) of Alzheimer's Disease, with special focus on earlier stages such as Subjective or Mild Cognitive Impairment (SCI/MCI).