DATAMITE empowers European companies by delivering a modular, open-source and multi-domain Framework to improve DATA Monetizing, Interoperability, Trading and Exchange, in the form of software modules, training, and business materials. DATAMITE unleashes the monetization potential at two levels. At internal level, users will have tools to improve quality management of their data, the adherence to FAIR principles, and will be able to upskill on technical and business aspects thanks to the multiple open-source training materials the project will generate. Therefore, data will become trustable and more reliable also in other paradigms like AI. At external level, keeping users in control of their data will provide new sources of revenue and interaction with other stakeholders. The architecture envisioned for DATAMITE enables DIHs sandboxing, becoming a potential instructor on their onboarding of SMEs and low-tech SMEs into the data economy. Together, DATAMITE’s solutions will function as a catalyst to boost data monetization in the European productive fabric. DATAMITE will validate the results in 3 different use cases with a total of 6 pilots, demonstrating that the Framework is interoperable and usable in different domains and user needs, as: 1) Intra-corporate, multi-domain data exchange; 2) Data trading among Data Spaces; 3) Integration with other initiatives as Data Markets, EU AI-on-demand platform, or DIHs. Sectors covered by the pilots are: agriculture, energy, industrial and manufacturing, and climate. To achieve this, the project relies on a consortium of 27 partners from 13 countries, bringing together key actors of the Data Value Chain: Data Spaces technical and business stakeholders, multiple key communities (IDSA, Gaia-X, EUHUBS4DATA, AI4EUROPE, EOSC), key experts in Legal and SSH aspects to guarantee legal and societal compliance, and facilitators on open-source community building and standardisation activities to accelerate the transfer to the market.