Fusion Power has the potential to solve one of society's greatest challenges: universal access to plentiful, safe & sustainable energy. A person's entire lifetime energy needs can be supplied from fusion energy using the deuterium taken from a domestic bath of water and the tritium that can be bred from the lithium in a single mobile phone battery. Fusion power plants cannot suffer any type of runaway and they do not produce any direct greenhouse gas emissions. However achieving fusion is technically challenging: it requires heating the deuterium & tritium fuel to millions of degrees. At this temperature, the fuel becomes a plasma - a gas of charged particles. The plasma must be confined for sufficient time at sufficient density in order to get more energy out than we put energy in. There are a number of approaches being explored but the most successful are (1) magnetic confinement fusion which holds the fuel by magnetic fields at relatively low density for relatively long times in a chamber called a tokamak, and (2) inertial confinement fusion which holds the fuel for a very short time but at huge densities. The exciting news is that fusion is now entering a golden era. Since 2020, there have been substantial scientific breakthroughs, such as at JET in the UK and at NIF in the US. There has been dramatic expansion into the private sector with over 30 companies globally pursuing a range of approaches and many more establishing the fusion supply chain; governments around the world, but especially in the UK, are investing to accelerate fusion delivery. A remaining critical barrier to making fusion a reality is the shortage of people who understand the inter-related operational constraints for both the plasma fuel and its containment materials, including the breeding of tritium from lithium, all of which must be satisfied simultaneously. The EPSRC CDT in Fusion Power will build on our existing success and international reputation to become the global beacon for training the next generation of fusion leaders. At the core of our CDT is the partnership between six leading research-intensive universities and more than 20 private companies, UK & international labs and government agencies. Our students will benefit from a systems-thinking-based technical training in plasma physics and materials science including tritium breeding & handling. They will benefit from training delivered by non-academic partners in topics such as regulation & licensing, commercialisation & entrepreneurship, sustainability, financing & investment and project management. Through the CDT partners, the students will use internationally leading experimental facilities and high performance supercomputers. Initially through their supervisors and then increasingly independently, students will access international networks of institutions and fusion professionals. During their PhD, students will have the opportunity to build their track record through presenting work at conferences and leading their own "collaboratory" mini project. These scientists and engineers will go on to solve the technical cross-disciplinary challenges, moving fusion forward faster at a rate of more than 20 scientists & engineers per year. We will increase diversity in the fusion community through: positive recruitment & admissions practices; supportive, cohort-based training activities; undergraduate fusion internships for students from under-represented groups; outreach to the public and via sustained relationships with target schools. This supply of the best people will energise the UK fusion industry and enable a global ambition for fusion power plant innovation & development.

Healthcare relies on medical devices, yet often these have significant risk of infection and failure. The medical device market is estimated to be just under US$500 billion, while US$25 billion is spent annually on treatment of chronic wounds. As our populations becomes older, our healthcare systems are also becoming stressed by multi-antibiotic resistance and viral outbreaks. For example, 50% of initial COVID-19 fatalities were due to secondary bacterial infections [Zhou et al. The Lancet, 2020]. Medical device failure rates of up to 20% burden our health service disproportionately through device centred infection, immune rejection, or both. The biomaterials that devices and external wound care products are made from significantly influence immune and healing responses and affect the outcome of infection. In the EPSRC Programme Grant "Next Generation Biomaterials Discovery", physical surface patterns (topographies) combined with novel polymers were found which both reduce bacterial biofilm formation and increase the immune acceptance of materials in vitro and in vivo in preclinical infection models. This provides a new paradigm for biomaterials used as implants and wound care products, where novel polymers can be topographically patterned to improved healing and acceptance using bio-instruction. To exploit these findings requires targeting to specific medical device environments and elucidation of the mechanism of action for translation by industry. This project will utilise 3D printing to manufacture ChemoTopoChips containing over a thousand polymer chemistry-topography combinations that allow the possible design space to be efficiently explored and mapped using semi-automated in-vitro measurements of host immune cell and infecting pathogen interactions individually and in co-culture. These ChemoTopoChips will allow a very high content of molecular information to be extracted from biomolecules secreted into the culture media (the secretome), those adsorbed to the surface (the biointerface) and their impact on both host cells and bacteria. The same fabrication approaches will be used to make devices for preclinical testing; in vivo information will be maximised using minimally invasive monitoring of infection and healing over time and detailed analysis of explants. These information streams will be merged using artificial intelligence (specifically machine learning) to build effective models of performance and provide mechanistic insight, allowing design of materials ready for translation as medical devices outside this project. After consultation with a wide range of clinicians we have chosen to target the following two devices: -Wound care products for chronic/non-healing wounds: dressings to reduce infection, induce immune-homeostasis and promote healing in chronic wounds that result in 7000 diabetes related amputations in the UK per year and cost the NHS £1bn a year to manage. -Implants requiring tissue integration but prone to fibrosis/adhesion and biofilm-associated infection: surgical meshes used for repair of hernias or pelvic organ prolapse commonly afflicting women after childbirth. The NHS undertakes 100k such operation each year with infection rates of up to 10%, plus foreign body response complications. The team assembled to exploit this opportunity has unique experience in the areas of biomaterials, artificial intelligence, additive manufacturing and in vitro and in vivo measurements of immune and bacterial responses to biomaterials. Facilities including the recently opened £100m Nottingham Biodiscovery Institute, the recently funded EPSRC £1m suite of high resolution/high throughput 3D printers and the unique £2.5m 3DOrbiSIMS Cat2 cryo-facility. These investments in Nottingham make this the only location in the world that is capable of undertaking this project. An Advisory Board of clinicians, industrial partners and leading academics will meet annually to provide input to the project.

The EPSRC CDT in Net Zero Aviation in partnership with Industry will collaboratively train the innovators and researchers needed to find the novel, disruptive solutions to decarbonise aviation and deliver the UK's Jet Zero and ATI's Destination Zero strategies. The CDT will also establish the UK as an international hub for technology, innovation and education for Net Zero Aviation, attracting foreign and domestic investment as well as strengthening the position of existing UK companies. The CDT in Net Zero Aviation is fully aligned with and will directly contribute to EPSRC's "Frontiers in Engineering and Technology" and "Engineering Net Zero" priority areas. The resulting skills, knowledge, methods and tools will be decisive in selecting, integrating, evaluating, maturing and de-risking the technologies required to decarbonise aviation. A systems engineering approach will be developed and delivered in close collaboration with industry to successfully integrate theoretical, computational and experimental methods while forging cross theme collaborations that combine science, technology and engineering solutions with environmental and socio-economic aspects. Decarbonising aviation can bring major opportunities for new business models and services that also requires a new policy and legislative frameworks. A tailored, aviation focused training programme addressing commercialisation and route to market for the Net Zero technologies, operations and infrastructure will be delivered increasing transport and employment sustainability and accessibility while improving transport connectivity and resilience. Over the next decade innovative solutions are needed to tackle the decarbonisation challenges. This can be only achieved by training doctoral Innovation and Research Leaders in Net Zero Aviation, able to grasp the technology from scientific fundamentals through to applied engineering while understanding the associated science, economics and social factors as well as aviation's unique operational realities, business practices and needs. Capturing the interdependencies and interactions of these disciplines a transdisciplinary programme is offered. These ambitious targets can only be realised through a cohort-based approach and a consortium involving the most suitable partners. Under the guidance of the consortium's leadership team, students will develop the required ethos and skills to bridge traditional disciplinary boundaries and provide innovative and collaborative solutions. Peer to peer learning and exposure to an appropriate mix of disciplines and specialities will provide the opportunity for individuals and interdisciplinary teams to collaborate with each other and ensure that the graduates of the CDT will be able to continually explore and further develop opportunities within, as well as outside, their selected area of research. Societal aspects that include public engagement, awareness, acceptance and influencing consumer behaviour will be at the heart of the training, research and outreach activities of the CDT. Integration of such multidisciplinary topics requires long term thinking and awareness of "global" issues that go beyond discipline and application specific solutions. As such the following transdisciplinary Training and Research Themes will be covered: 1. Aviation Zero emission technologies: sustainable aviation fuels, hydrogen and electrification 2. Ultra-efficient future aircraft, propulsion systems, aerodynamic and structural synergies 3. Aerospace materials & manufacturing, circular economy and sustainable life cycle 4. Green Aviation Operations and Infrastructure 5. Cross cutting disciplines: Commercialisation, Social, Economic and Environmental aspects 75 students across the UK, from diverse backgrounds and communities will be recruited.

Most advanced materials are actually composite systems where each part is specifically tailored to provide a particular functionality often via doping. In electronic devices this may be p- or n-type behaviour (the preference to conduct positive of negative charges), in optical devices the ability to emit light at a given wavelength (such as in the infrared for optical fibre communications), or in magnetic materials the ability to store information based on the direction of a magnetic field for example. To enable the realisation of new devices it is essential to increase the density of functionality within a given device volume. Simple miniaturisation (i.e. to fit more devices of the same type but of smaller size) is limited in scope as the nanoscale regime is reached, not only by the well-known emergence of quantum effects, but by the simple capability to control the materials engineering on this scale. Self-assembly methods for example enable the creation of 0D (so called 'quantum dots' or 'artificial atoms'), 1D (wire-like) and 2D (sheet-like) materials with unique properties, but the subsequent control and modification of these is non-trivial and has yet to be demonstrated in many cases. This research aims to establish a Platform for Nanoscale Advanced Materials Engineering (P-NAME) facility that incorporates a new tool which will provide the capability required to deliver a fundamental change in our ability to design and engineer materials. The principle of the technique that we will adapt, is that which revolutionised the micro-electronics industry in the 20th century (ion-doping) but applied on the nanoscale for the first time. Furthermore, the P-NAME tool will be compatible with a scalable technology platform and therefore compatible with its use in high-tech device manufacture. Without this capability the production of increasingly complex materials offering enhance functionality at lower-power consumption will be difficult to achieve. The P-NAME facility will be established within a new UK National Laboratory for Advanced Materials (the Henry Royce Institute) at the University of Manchester. Access to the tool will be made available to UK academics and industry undertaking research into advanced functional materials and devices development.

We will install a 300kV aberration corrected STEM that utilises artificial intelligence (AI) to simultaneously improve the temporal resolution and precision/sensitivity of images while minimizing the deleterious effect of electron beam damage. Uniquely, this microscope goes beyond post-acquisition uses of AI, and integrates transformational advances in data analytics directly into its operating procedures - experiments will be designed by and for AI, rather than by and for a human operator's limited visual acuity and response time. This distributed algorithm approach to experimental design, is accomplished through a compressed sensing (CS) framework that allows measurements to be obtained under extremely low dose and/or dose rate conditions with vastly accelerated frame rates. Optimizing dose / speed / resolution permits diffusion to be imaged on the atomic scale, creating wide-ranging new opportunities to characterise metastable and kinetically controlled materials and processes at the forefront of innovations in energy storage and conversion, and the wide range of novel engineering/medical functionalities created by nanostructures, composites and hybrid materials. The microscope incorporates in-situ gas / liquid / heating / cryo and straining / indentation stages to study the dynamics of synthesis, function, degradation / corrosion and regeneration / recycling on their fundamental length and time scales. It will be housed in the Albert Crewe Centre (ACC), which is a University of Liverpool (UoL) shared research facility (SRF) specialising in new experimental strategies for high-resolution/operando electron microscopy in support of a wide range of academic/industrial user projects. UoL supports all operational costs for the SRFs (service contracts, staff, consumables, etc), meaning that access to the microscope will always be "free at the point of use" for all academic users. This open accessibility is managed through a user-friendly online proposal submission and independent peer review mechanism linked to an adaptable training/booking system, which allows the ACC to provide extensive research opportunities and training activities for all users. In particular, for early career scientists, we commit experimental resources supporting UoL's commitment to the Prosper project for flexible career development and the Research Inclusivity in a Sustainable Environment (RISE) initiative that is creating a research culture maximising inclusivity and diversity synergistically with encouraging creativity and innovation. This new microscope aligns to several priority areas of research into materials, energy and personalised medicine at the UoL, priority research areas of EPSRC and national facilities in electron microscopy, imaging and materials science, and UKRI plans for infrastructure growth (https://www.ukri.org/research/infrastructure/). In addition to supporting extensive research programs at UoL linked to investments in the Materials Innovation factory (MIF), the Stephenson Institute for Renewable Energy (SIRE) and the new Digital Innovation Facility (DIF), this unique and complimentary microscope will be affiliated to and leverage from partnership with the national microscopy facilities at Harwell (ePSIC) and Daresbury (UKSuperSTEM) and the Henry Royce Institute, as well as form extensive research links to the Rosalind Franklin Institute and the Faraday Institution. We have established (and will expand through outreach activities) an extensive network of partners/collaborators from the N8 university group, Johnson Matthey and NSG, the Universities of Swansea, Birmingham, Warwick, Oxford, Cambridge, Loughborough, Edinburgh and Glasgow and Northwest UK area SME's as well as from universities in the USA, Ireland, Germany, Japan, France, Italy, Denmark, India, Singapore, China, South Africa and Spain who will create a dynamic, innovative and collaborative community driving the long-term research impact of this facility.