KYKLOS 4.0 will demonstrate, in a realistic, measurable, and replicable way the transformative effects that CPS, PLM, LCA, AR and AI technologies and methodologies will have to the Circular Manufacturing (CM)Framework. To this end, KYKLOS 4.0 will (1) perform large-scale piloting in 7 pilots to demonstrate the technical, environmental and economic viability of KYKLOS 4.0 Ecosystem to reshape intra-factory processes and services, (2) show KYKLOS 4.0 value in terms of operational efficiency improvements by at least 15%, (3) deliver resources reusable solutions (second use of material, part and components reuse) for the whole manufacturing sectors, (4) ensure scalability for future scale of novel CM technologies and services at least at the level of year 2024, (5) engage over 100 key European industry actors, (through open calls and workshops) (6) transfer knowledge and technology to increase use of KYKLOS 4.0 Ecosystem to at least 50%, (7) strengthen the position of EU CM technologies providers and sector fostering a market share of up to 12% (8) pursue a strong plan for sustainability by incubating at least 3 post-project replication sites, (9) mobilize additional sector investments of at least 6 times the EC contribution. Bringing together knowledge and solutions of major European CPS, PLM, LCA and AI technology providers together with the competence and experience of key European industry players in the CM domain, KYKLOS 4.0 will demonstrate a measurable increase of KYKLOS 4.0 Ecosystem penetration in CM market, reduction of environmental impact due to the reduce of the use of fossil fuels and raw materials and impact in seven pilot domains, which cover areas of major importance for the CM sector in EuropeA unique characteristic of KYKLOS 4.0 is that all CM related technologies, sectors and stakeholders together with their relevant expertise are covered. Thereby, the delivered by KYKLOS 4.0 are relevant for the whole manufacturing sector and market in Europe.