The Turkana and Awash basins in the East African Rift, preserve an exceptional fossil and archaeological record and to a large extent, form the basis for our current understanding of early hominin environments. Ancient volcanic activity has left numerous ash deposits (tuffs) that can be dated using the radiometric dating method 40Ar/39Ar. Although precise, dates obtained by this method only provide broad envelopes with significant temporal gaps because volcanism is episodic, and tuffs do not always survive across the landscape. Furthermore, despite the abundance of archaeological finds and animal fossils in this region, datable tuffs are rare in the East African Rift. Consequently, age estimation often relies on imprecise relative methods, such as magnetostratigraphy and biostratigraphy. A method for obtaining absolute dates is urgently required in order to correlate all the sedimentary sequences within the eastern rift, as well as across Africa, and to help clarify the wider picture of early human biological and cultural events during the Plio-Pleistocene. Likewise, the South African sites also suffer from dating problems, albeit from different issues. In most of these cases they are karstic infills and only recently, have any absolute methods based on cosmogenic and uranium/lead isotope systems been applied. These techniques also leave huge gaps and/or do not precisely date the fossil or archaeological event of interest. For instance, U/Pb dates generally reflect the ages of over- or underlying flowstone and not that of a fossil. We propose to apply a novel luminescence-based method known as infrared-radiofluorescence (IR-RF), which the named researcher co-investigator on this proposal helped to develop, in order to determine the age (i.e. time of deposition) of fossil- and artefact-bearing sediments and/or volcanic tuffs in Kenya, Ethiopia and South Africa and to fill in the time gaps omitted by radiometric techniques. The IR-RF method is widely applicable due to the ubiquitous occurrence of sand sized feldspar mineral grains required for dating and the technique targets potassium- (K-) rich feldspar, one of the most common types of mineral on earth. Recent studies suggest that this methodology has the potential to extend the age range of luminescence dating from 0.5 million years to 4 million years, thus encompassing the majority of the time range over which the human family evolved. Methods of recording and analyzing luminescence data have developed significantly over the last five years, including improved light detection and more advanced analytical and statistical techniques, all of which have led to new approaches and more flexible ways of processing and visualizing data. Recent technological advances including the development of single photon imaging systems based on electron multiplying charge coupled devices (EMCCD) also suggest that the time is right to bring together and apply some of these new cutting-edge innovations to help achieve more reliable chronologies for early hominin evolution. This research will dramatically increase the number of well-dated sequences in areas archiving key evidence for early human evolution and it will enable us to provide significant improvements in correlating human fossil records across Africa. A new and more refined chronological framework will greatly improve our understanding of the diversity of adaptive challenges faced by early hominins since the Pliocene and it will help to shed more light on the hotly debated question of the role of climatic and ecological changes in driving hominin evolution.

East Africa (EA) has one of the world's fastest growing populations, with maxima around water-bodies and rapid urbanisation. Climate change is adding to existing problems increasing vulnerability of the poorest. HyCRISTAL is driven by EA priorities. EA communities rely on rainfall for food via agriculture. EA's inland lakes are rain-fed and provide water, power and fisheries. For EA's growing cities, climate impacts on water resources will affect water supply & treatment. HyCRISTAL will therefore operate in both urban & rural contexts. Change in water availability will be critical for climate-change impacts in EA, but projections are highly uncertain for rain, lakes, rivers and groundwater, and for extremes. EA "Long-Rains" are observed to be decreasing; while models tend to predict an increase (the "EA Climate paradox") although predictions are not consistent. This uncertainty provides a fundamental limit on the utility of climate information to inform policy. HyCRISTAL will therefore make best use of current projections to quantify uncertainty in user-relevant quantities and provide ground-breaking research to understand and reduce the uncertainty that currently limits decision making. HyCRISTAL will work with users to deliver world-leading climate research quantifying uncertainty from natural variability, uncertainty from climate forcings including those previously unassessed, and uncertainty in response to these forcings; including uncertainties from key processes such as convection and land-atmopshere coupling that are misrepresented in global models. Research will deliver new understanding of the mechanisms that drive the uncertainty in projections. HyCRISTAL will use this information to understand trends, when climate-change signals will emerge and provide a process-based expert judgement on projections. Working with policy makers, inter-disciplinary research (hydrology, economics, engineering, social science, ecology and decision-making) will quantify risks for rural & urban livelihoods, quantify climate impacts and provide the necessary tools to use climate information for decision making. HyCRISTAL will work with partners to co-produce research for decision-making on a 5-40 year timescale, demonstrated in 2 main pilots for urban water and policies to enable adaptive climate-smart rural livelihoods. These cover two of three "areas of need" from the African Ministerial Council on Environment's Comprehensive Framework of African Climate Change Programmes. HyCRISTAL has already engaged 12 partners from across EA. HyCRISTAL's Advisory Board will provide a mechanism for further growing stakeholder engagement. HyCRISTAL will work with the FCFA global & regional projects and CCKE, sharing methods, tools, user needs, expertise & communication. Uniquely, HyCRISTAL will capitalise on the new LVB-HyNEWS, an African-led consortium, governed by the East African Community, the Lake Victoria Basin Commission and National Meteorological and Hydrological agencies, with the African Ministerial Conference on Meteorology as an observer. HyCRISTAL will build EA capacity directly via collaboration (11 of 25 HyCRISTAL Co-Is are African, with 9 full-time in Africa), including data collection and via targeted workshops and teaching. HyCRISTAL will deliver evidence of impact, with new and deep climate science insights that will far outlast its duration. It will support decisions for climate-resilient infrastructure and livelihoods through application of new understanding in its pilots, with common methodological and infrastructure lessons to promote policy and enable transformational change for impact-at-scale. Using a combination of user-led and science-based management tools, HyCRISTAL will ensure the latest physical science, engineering and social-science yield maximum impacts. HyCRISTAL will deliver outstanding outputs across FCFA's aims; synergies with LVB-HyNEWS will add to these and ensure longevity beyond HyCRISTAL.

Biomedical Materials have advanced dramatically over the last 50 years. Historically, they were considered as materials that formed the basis of a simple device, e.g. a hip joint or a wound dressing with a predominant tissue interface. However, biomedical materials have grown to now include the development of smart and responsive materials. Accordingly, such materials provide feedback regarding their changing physiological environment and are able to respond and adapt accordingly, for a range of healthcare applications. Two major areas underpinning this rapid development are advances in biomedical materials manufacture and their characterisation. Medical products arising from novel biomedical materials and the strategies to develop them are of great importance to the UK and Ireland. It is widely recognised that we have a rapidly growing and ageing population, with demand for more effective but also cost effective healthcare interventions, as identified in recent government White Paper and Foresight reports. This links directly to evidence of the world biomaterials market, estimated to be USD 70 billion (2016) and expected to grow to USD 149 billion by 2021 at a CAGR of 16%. To meet this demand an increase of 63% in biomedical materials engineering careers over the next decade is predicted. There is therefore a national need for a CDT to train an interdisciplinary cohort of students and provide them with a comprehensive set of skills so that they can compete in this rapidly growing field. In addition to the training of a highly skilled workforce, clinically and industrially led research will be performed that focuses on developing and translating smart and responsive biomaterials with a particular focus on higher throughput, greater reproducibility of manufacture and characterisation. We therefore propose a CDT in Advanced Biomedical Materials to address the need across The Universities of Manchester, Sheffield and The Centre for Research in Medical Devices (CÚRAM), Republic of Ireland (ROI). Our combined strength and track record in biomaterials innovation, translation and industrial engagement aligns the UK and ROI need with resource, skills, industrial collaboration and cohort training. This is underpinned strategically by the Biomedical Materials axis of the UK's £235 million investment of the Henry Royce Institute, led by Manchester and partner Sheffield. To identify key thematic areas of need the applicants led national Royce scoping workshops with 200 stakeholders through 2016 and 2017. Representation was from clinicians, industry and academia and a national landscape strategy was defined. From this we have defined priority research areas in bioelectronics, fibre technology, additive manufacturing and improved pre- clinical characterisation. In addition the need for improved manufacturing scale up and reproducibility was highlighted. Therefore, this CDT will have a focus on these specific areas, and training will provide a strongly linked multidisciplinary cohort of biomedical materials engineers to address these needs. All projects will have clinical, regulatory and industry engagement which will allow easy translation through our well established clinical trials units and positions the research well to interface with opportunities arising from 'Devolution Manchester', as Greater Manchester now controls long-term health and social care spending, ready for the full devolution of a budget of around £6 billion in 2016/17 which will continue through the CDT lifespan.

A primary aim of lava flow research is the development of accurate flow models that can be used to forecast areas of inundation, and to estimate how far lavas will advance before stopping. Lava flows are complex fluids comprising mixtures of crystals, liquid and gas bubbles and, as they flow, they cool and lose volatile species (mainly water and carbon dioxide) that were initially dissolved in the melt at high pressure beneath the surface. Both cooling and degassing lead to crystallisation of the liquid melt, and thus have significant influence on flow advance. Cooling is a major driver of crystallisation, but its effects are mainly restricted to the thermal boundary layers, where it is an integral process in the formation of surface crust and lateral levées. In contrast, degassing is not restricted to boundary layers and occurs throughout flows, with the potential to affect the entire bulk rheology. Although the effects of cooling-driven crystallisation are accounted for in the current generation of lava flow models, crystal growth due to degassing has not yet been sufficiently quantified to allow its incorporation into models. In recent laboratory experiments, we have been able to simultaneously measure degassing and crystallisation for the first time, and we propose to further this research by examining the growth of crystals directly using hot stage microscopy. This will provide the data on crystal sizes, growth rates and morphologies necessary to quantify the contribution of degassing to the overall crystallisation of lavas. Ultimately, these results will allow degassing-induced crystallisation to be accounted for in numerical lava flow models.