Insights into the functioning of the innate immune system are crucial to be able to design appropriate immunotherapies. However, we still lack basic knowledge regarding the regulation of innate sensing by nucleic acid sensors named endosomal Toll-Like Receptors (TLRs). Our project aims at deciphering the molecular mechanisms governing the regulation of nucleic acid sensing by endosomal TLRs through the control of their intracellular trafficking. Focusing on TLR3, we will study important molecular players to determine how and where TLR3 traffics, meets its ligand and signals. This knowledge will be transposed in a mouse model of TLR3-dependent and antigen specific immune response. The control of innate immune receptor signalling through their trafficking is a relatively nascent field that shows immense potential for the discovery of molecules that could precisely control signaling and the downstream immune response during immunotherapeutic strategies

L'EMJM Techniques, Patrimoine, Territoires de l'Industrie (TPTI) forme à la connaissance et à la patrimonialisation des techniques. Coordonné par l'univ. Paris 1 Panthéon-Sorbonne, il délivre un diplôme conjoint avec les univ. de Padoue et d'Evora, et six universités partenaires : Oviedo (Espagne) ; Prague (République Tchèque) ; Sfax (Tunisie) ; Cheikh Anta Diop (Sénégal) ; Cordoba (Argentine) ; Kagoshima (Japon). Le consortium a co-construit un champ historico-patrimonial innovant portant sur la culture matérielle et immatérielle de la production (patrimoine artisanal et industriel) et couvrant un vaste domaine allant de l'objet au territoire. Il vise à promouvoir la connaissance et la préservation des cultures techniques par le décloisonnement des secteurs de l’histoire et du patrimoine et une approche globale comparative, attentive aux enjeux environnementaux actuels. Le Master bénéficie de la complémentarité disciplinaire des partenaires. Pour favoriser l'interculturalité, tous les étudiants suivent le même cursus du S1 au S3. D’abord à Paris (S1, Histoire et anthropologie des techniques), puis à Padoue (S2, Patrimoine industriel) et à Evora (S3, Paysages culturels et techniques). Au S4, ils rejoignent l’une des univ. partenaires en petits groupes (5 ECTS), puis leur univ. de soutenance de mémoire (Paris, Padoue ou Evora). Le programme est multilingue. La première langue est le français, la seconde l'anglais. Des cours d'italien, de portugais et d'anglais sont donnés tout au long du programme. TPTI est ouvert aux historiens, architectes, spécialistes de la culture, économistes et gestionnaires du patrimoine. Il ouvre aux métiers de la conservation, du patrimoine et de la médiation culturelle, à la gestion de musée ou de site, à l'archéologie industrielle, au tourisme technique et industriel, au consulting, mais aussi à l'enseignement et à la recherche. Pour cela, l’équipe mêle enseignants chercheurs et praticiens et dispense des cours théoriques et pratiques.

The development of Information and Communication Technologies (ICT) and specifically Internet of Things (IoT) in Argentina and Uruguay is growing at a relatively slow pace and we found the main reasons being: the lack of cooperation, the scarceness of human resources in the area of interest, and the heterogeneous thus ineffective educational methodology and offer in a state of the art topic. The aim of the project NEON is therefore to modernize the higher education system, to improve and diversify the training of human resources, both in the academic field (students, professors,) and in the industrial sphere (technical staff) and to motivate a broader spectrum of people towards IoT, which nowadays is one of the most innovative and most impactful technology in the ICT field, as it can influence and improve several aspects and processes of our lives. The main goal of the institutions that take part in the project will be the creation of a Network of Competence in IoT. This network of competence will serve as a hub and common knowledge base for both academia and industry in order to foster an improved technological advancement through exchange of knowledge and needs. Specifically, the network of competence will connect universities in Argentina and Uruguay with local industry (and with EU universities) in order to address their needs, offer teaching and training opportunities to both teachers, staff and students, improve the infrastructure through the creation of joint university-academia laboratories and offer internships. All these activities will be related to modernizing the curricula by including the IoT topic, developing new hands-on based education, acquiring digital skills and learning methods to strengthen the relation between HEIs and the wider economic and social environment fostering capacity building, innovation, creativity and employability so that to contribute to local economy growth.