I believe our track record with the BBSRC and our publications demonstrate we can achieve the goals of this exciting project and successfully return this grant with novel and significant insights and advances to LIMD1 biology and the HIF signalling pathway. Optimum levels of oxygen are required throughout the cells and tissues of our body for survival. Referred to as 'oxygen homeostasis', this is tightly regulated in animals and indeed all multicellular organisms to ensure that tissues are sufficiently supplied with oxygen. Whilst oxygen levels range within the human body from 21% in the upper airway to an average of 5% in most organs, each tissue type has a requirement for a certain concentration of oxygen, below which essential cellular processes such as energy production, protein synthesis and cell growth and division become impaired. Rapid reaction and adaptation of a cell or tissue to low oxygen concentrations ('hypoxia') can enable cells to remain viable, thus reducing potential damage to the organism. This is known as the 'hypoxic response'. Deregulation of the hypoxic response is a key characteristic in cancer development and also large tumour growth and its spread throughout the body. Furthermore, deregulation of this key cellular control process is also linked to many non-cancerous diseases such as neurological disease, myocardial infarction (heart attacks), stokes, and many ischemic (low oxygen) related diseases. Therefore, a complete understanding of the molecular biology of this critical cellular control process remains an important focus for basic cell and molecular biology research worldwide. To this end we have recently identified a protein called LIMD1 that is a critical to regulating the normal function of the hypoxic response. Furthermore, we have shown that loss of this protein creates a pseudo-hypoxic environment within the cell, causing it to react as if it is in one of the hypoxic diseased states mentioned above. Our discovery therefore represents a new unknown level of molecular biology critical for the hypoxic response. Moreover, we are currently the only group in the world to be researching this specific area of hypoxic regulation, and hopefully with this BBSRC award, we can continue to investigate this exciting new molecular biology. Furthermore, such information will represent a major new avenue of investigation to basic and clinical molecular biological researchers in this field and represent a new set of protein targets for future development of hypoxic disease-related drug therapies and treatments.

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

The overall aim of this project is to coordinate a global research network on the history of the human sciences in China from the late imperial period to the present. In leading up to the establishment of this research network, the proposed series of academic and impact activities (including conferences, panels, workshops, and public lectures) will generate two specific research outputs. The first is the production of a comprehensive text that introduces the historical development of various aspects of the human sciences in China since 1600. Incorporating feedback from practitioners in the human sciences and the relevant health professions over the course of this networking project, this text will be organized around four themes: "parameters of the living," "making of the modern subject," "disciplining knowledge," and "deciphering health." This book will serve as a state-of-the-field survey, a landmark textbook for teaching, and a field-consolidating reference for inspiring future research. The second is the publication of a special issue of _History of Science_, a leading journal in the field of the history of science, on "The Sciences of the Human in Modern China." This journal volume will feature original articles that represent newest research in the history of the Chinese human sciences. This research network extends the most cutting-edge research agenda of global Chinese studies. Given that the preoccupation with knowledge about "being human" and human difference has a long history and continues to take on different configurations within the field of China studies, the proposed research network provides a timely opportunity for scholars-both emerging and advanced-who have been looking at similar historical issues, but who have yet to come together as a group in order to synthesize their overlapping concerns. In consolidating a global research network around the theme of "China and the Human Sciences," the proposed series of activities will also make major interventions beyond Sinology, such as in the fields of comparative literature, cultural studies, and the history and philosophy of science. These interventions will build on the long chronological focus of this project and thereby problematize conventional chronological divisions (e.g., early modern, modern, contemporary, etc.) that are widely adopted in disciplines across the humanities. They will also contribute new historical insights to contemporary debates on the contradictory perceptions of China in mainstream Western discourses as the anti-thesis of human rights and a rising economic superpower.

Our programme focuses on the care needs of adults living at home with chronic health problems or disabilities, and seeks sustainable solutions to the UK's contemporary 'crisis of care'. It is distinctive in investigating sustainability and wellbeing in care holistically across care systems, work and relationships; addresses disconnection between theorisations of care in different disciplines; and locates all its research in the context of international scholarship, actively engaging with policy partners. It will fill knowledge gaps, contribute new theoretical ideas and data analyses, and provide useful, accurate evidence to inform care planning, provision and experience. It develops and critically engages with policy and theoretical debates about: care infrastructure (systems, networks, partnerships, standards); divisions of caring labour/the political economy of care (inequalities, exploitation); care ethics, rights, recognition and values (frameworks, standards, entitlements, wellbeing outcomes); care technologies and human-technological interactions; and care relations in emotional, familial, community and intergenerational context. Our team comprises 20 scholars in 7 universities, linked to an international network spanning 15 countries. Our programme comprises integrative activities, in which the whole team works together to develop a new conceptual framework on sustainable care and wellbeing, and two Work Strands, each with 4 linked projects, on 'Care Systems' & 'Care Work & Relationships'. 'Care Systems' will: (i) study prospects, developments and differentiation in the four care systems operating in England, N. Ireland, Scotland & Wales, comparing their approaches to markets, privatisation and reliance on unpaid care; (ii) model costs and contributions in care, covering those of carers and employers as well as public spending on care; (iii) assess the potential of emerging technologies to enhance care system sustainability; and (iv) analyse, in a dynamic policy context, migrant care workers' role in the sustainability of homecare. 'Care Work & Relationships' will: (i) develop case studies of emerging homecare models, and assess their implications for sustainable wellbeing; (ii) focus on carers who combine employment with unpaid care, filling gaps in knowledge about the effectiveness of workplace support and what care leave and workplace standard schemes can contribute to sustainable care arrangements; (iii) explore how care technologies can be integrated to support working carers, ensuring wellbeing outcomes across caring networks; and (iv) investigate care 'in' and 'out of' place, as systems adapt or come under pressure associated with population diversity and mobility. Each project will collaborate with our international partners. These scholars, in 26 collaborating institutions, will ensure we learn from others about ways of understanding, measuring or interpreting developments in how care is organised and experienced, and keep up to date with latest research and scholarship. Our capacity-building strategy will build future scholarly expertise in the study of sustainability and wellbeing in care, and ensure our concepts, methods, and research findings achieve international standards of excellence. Universities in our partnership are contributing 5 UK & 12 overseas PhD studentships, enabling us to form an international early career scholar network on sustainable care, supported by our senior team and partners. Our impact strategy, led by Carers UK, involves leading UK and international policy partners. Informing policy, practice and debate, we will co-produce analyses and guidance, enhance data quality, promote good practice and engage decision-makers, policymakers, practitioners in the public, private and voluntary sectors, carers, people with care needs, and the media. Our Advisory Board of leading academics, policy/practice figures and opinion formers will guide all our work.