The PragmaTIL trial aims to optimize treatment of cancer patients with Tumour-Infiltrating Lymphocytes Adoptive Cell Therapy (TIL-ACT) and substantially expand and improve the clinical implementation of this treatment modality in academic hospitals. To this end, treatment related toxicities, associated to high-dose interleukin 2 (HD-IL-2) required for expansion and activation of TILs will be reduced while maintaining efficacy. This improved tolerability will achieve a better clinical management of patients and enhance their quality of life, both of which represent major barriers for applying this treatment. The objectives of PragmaTIL are: i) To determine whether TIL-ACT using IL-2 analog ANV419 reduces the frequency of Grade 2-4 study-related non-hematological toxicities; ii) To compare the quality of life (QoL) of patients during their hospitalization period, using ANV419 vs HD-IL-2. Also, to compare short and long-term measurements of treatment-related toxicities and QoL co-defined by and for patients and their caregivers; and iii) To develop the health technology assessment (HTA) of TIL-ACT using ANV419, as well as a social return of investment (SROI) analysis. To achieve these objectives, the PragmaTIL project is structured into 6 WP that cover all the requirements to implement the project: WP1) Clinical Trial; WP2) IMPD Coordination, RA and Pharmacovigilance; WP3) Patients as co-researchers and Evaluation of Short- and Long-term PROs; WP4) Health Economics; WP5) SROI, Sustainability and Exploitation; WP6) Scientific Coordination, Project Management, Communication and Dissemination. The global impact of this project will not only reach patients, clinical and translational researchers and policy makers but may help to achieve a better acceptance of these therapies by society at large. This action is part of the Cancer Mission cluster of projects on "Diagnosis and treatment".

Despite efforts to reduce fragmentation across the European Research Area, the European scientific system is still facing challenges in achieving gender equality and gender mainstreaming in research and innovation. In this context, and in line with ERA policy goals and national contexts, the GENDER-NET Plus ERA-NET Cofund aims to strengthen transnational collaborations between research programme owners and managers, provide support to the promotion of gender equality through institutional change and instigate the integration of sex and gender analysis into research and funding programmes. To do so, project partners – a consortium of 16 committed organisations – will join forces to 1) Implement a joint co-funded call for proposals, 2) Design and implement transnational actions on the promotion of gender equality through institutional change and the integration of sex and gender analysis into research, 3) Update and enlarge the mappings and analyses carried out in GENDER-NET on the promotion of gender equality in research and innovation, 4) Carry out a joint assessment of gender differences and bias in access to research grants and define and develop appropriate conditions for promoting equal opportunities in research funding, 5) Promote and disseminate key findings. GENDER-NET will address these goals through 7 work packages and relies on a strong transnational cooperation between partner EU Member States, Associated Countries, and Third Countries, to contribute to the advancement of gender equality in the ERA.

In the LIV:IN project, major industry leaders from the ICT sector join forces to co-create more responsible approaches to innovation for the first time. LIV:IN builds on the premise that recognition of the value of RRI among industry is necessary for achieving the aim of the call “to progress further in integrating RRI in industrial contexts”. The project follows an opportunity oriented approach in order to (1) activate industry leaders, experts and citizens to experiment with responsible ways of co-creating innovations; (2) build capacity for RRI implementation and develop tools that are applicable across industry sectors; and (3) transform attitudes towards RRI from risk to opportunity. LIV:IN will demonstrate the added value of RRI in the area of smart future living. We carefully selected this application area because it directly impacts the lives of citizens (societal relevance) but also constitutes a major emerging market (business opportunity). The project includes four key features that will significantly enhance the quality of the proposed coordination and support activities. First, six LIV:IN Labs and a virtual community of practice will constitute the central spaces for experimentation with integrating RRI in industry, and, consequently, the development of new approaches to innovation. Second, the application and continuous improvement of RRI tools in these spaces will contribute to capacity-building among industry and citizens alike. Third, embedded audio-visual story-telling will be the main vehicle for disseminating results and for shifting attitudes towards RRI from risk to opportunity. Finally, continuous dialogue with earlier and present initiatives in the areas of RRI, CSR and open innovation will ensure the transferability of project results across industry sectors. Ultimately, LIV:IN is guided by its vision to become a flagship initiative for effective integration of RRI in industry.

Higher Education Institutions and Responsible Research and Innovation (HEIRRI) foster an alignment of research and innovation (R&I) with the needs, values and societal expectations. The six key aspects of “Responsible Research and Innovation (RRI)”-societal/public engagement, gender equality, open access, science education, ethics and governance in R&I-are transdisciplinary included at all stages of formation of scientist and engineers, and other professional fields involved in R&I. HEIRRI will create and share on OA a stock-taking inventory constituted by a State of the Art Review and a Data Base. The inventory will gather results of other EU funded RRI projects, good cases and practices of RRI and RRI Learning. Also, different stakeholders involved and/or affected by R&I will participate in a debate and reflection process on RRI Learning through online and offline Forum actions. Results from the inventory will represent the basis for RRI Training programs and formative materials, offering the students knowledge and skills to develop viable solutions to specific problems related to R&I, integrating theory and practice. They will be designed for the different HEI educational levels (undergraduate, MD and PhD, summer courses and MOOC), mainly based on Problem based learning methodology, and supported by multimedia materials (videos and microvideos, 2.0 materials, etc.). All results and products elaborated by HEIRRI will be uploaded on OA at RRITools Platform. An internationalization plan will guarantee their spreading awareness and future use by HEI from Europe and beyond. A global scope and expertise on RRI will be provided by HEIRRI consortium that consists of 5 European HEI (Universitat Pompeu Fabra (UPF), Universitetet I Bergen (UiB), Aarhus Universitet (AU), Institut Fuer Hoehere Studien und Wissenschaftliche Forschung (IHS), Sveuciliste u Splitu (University of Split, UNIST)), the European network of science centres and museums (AEESTI / Ecsite), Fundación Bancaria Caixa D'estalvis i Pensions de Barcelona La Caixa (FBLC), a network of universities (Associació Catalana d'Universitats Públiques, ACUP), and a private company specialized in R&I (INNOVATEC).

Our priority is that through this project all project partners will be collaborating with the youth workers and with the youth to engage them in informal education in relation to STEAM and science communication. Moreover, sharing the knowledge and experiences would enhance the projects' outputs; namely the interactive resource including a high quality video of a science show, and public speaking/ debate skills sets. Youth participation strengthens personal and social development, provides expertise for youth programmes and services, and promotes a more democratic society. In the context of complex inter-generational challenges such as climate change and sustainable development, it is increasingly important for scientists and policy-makers to actively engage with and support the meaningful participation of youth in policy and decision-making.Art, theatre and storytelling will be used as media for youth upskilling and engagement. The first phase of the project will involve a triangulation research with youth and the surrounding communities and a training programme by a well established cultural organisation in which together with the youth entity will provide a comprehensive upskilling programme for science communicators on collaborating with youth. Using the research and the training through several matchmaking sessions youth workers, science communicators, artists and the youth will work together to produce the interactive resource. Transnational meetings will be used for the science centres, youth agency and the artistic organisation to monitor progress and plan ahead. Upon its completion the interactive resource will be presented during the three non formal multiplier events named Youth Science Cafes. During these multiplier events youth will be actively involved in their organisation and will also actively participate in the science show and science cafe. These multiplier events will be targeting more youths through the participation from the surrounding communities. Through these cafes, youths are presented with the opportunity to speak about their involvement in informal education; in connection to science communication and STEAM subjects. Furthermore, the interactive resource would be freely available to the public on the Websites of science centres. The innovative aspect of this project is that the science show would be developed on the basis of research conducted as part of this project in collaboration with the Youth Agency, involving the youths. Further more, a concluding conference would be held in Malta bringing together representatives from stakeholders in non formal education, science communication, youth work, youths and the art sectors. The conference will enable sharing of best practices and experiences, dissemination of the project outputs through the active involvement of the youths and specific workshops.