Medical diagnostics is moving from laboratory to bedside. There is a strong trend for complex laboratory analyses to be supplemented, or even replaced, by tests that can be performed at the point-of-care (PoC) by personnel with little or no specialist training. An important feature of PoC tests is their short time-to-result. Provision of diagnostic information at or near real-time supports clinical decisionmaking by enabling rapid and targeted intervention, which improves patient outcome and promotes efficient use of limited healthcare resources. To this end, development of novel instrumentation capable of rapid and accurate measurement of chemical indicators of disease (biomarkers) is a strategic priority. Clostridium difficile infection (CDI) is an example of an unmet clinical need for PoC diagnostics and is the main focus of this study. CDI is a hospital-acquired infection which produces catastrophic diarrhoea, prolongs hospital stays and can prove fatal in vulnerable individuals. It is highly contagious - current UK NHS intervention policy requires that patients with unexplained diarrhoea must be isolated and treated for the disease before a positive diagnosis is available. Current tests for CDI use traditional laboratory "wet chemistry" enzymatic and nucleic acid assays, with limited diagnostic performance and a lead time measured in hours. Misdiagnosis can lead to patients being unnecessarily isolated from wards or treated unnecessarily with antibiotics, which contributes to the development of antimicrobial resistance. Variation in the levels of volatile organic compounds (VOCs) emitted from a range of human samples (e.g. breath, blood, urine) are known to be associated with metabolic status and have been linked to particular diseases. The gastrointestinal tract offers a particularly rich source of information, since many disease states are associated with changes in the bacterial population of the gut (the microbiome) resulting in changes to the VOCs produced, which can be measured using optical spectroscopy. Our vision is to develop a novel approach based on optical measurement of these volatile biomarkers in the gas phase. By measuring the level of specific biomarker chemicals produced by samples of patients' faeces, we aim to provide early warning of the development of gastric disease. Important benefits of this approach are: - Samples of faeces are taken using standard clinical procedures, as is normal practice today when symptoms develop. - Volatile markers may be measured using laser spectroscopy, with a short time-to-result (1-2 minutes). The measurement is highly selective to individual VOCs, which importantly will allow identification of biomarkers against a complex background matrix of over 300 species. - The method requires minimal sample preparation, avoiding the use of reagents and making it suitable for point-of-care diagnosis. - Because the measurement system is not in physical contact with the sample, there is no interference or fouling of the sensor. - It is clinically non-invasive, so is suitable for repeated use in disease monitoring, unlike techniques such as colonoscopy and sigmoidoscopy which are widely used in chronic disease diagnosis but cannot be used on a daily basis. - The method will allow active disease to be distinguished from mere carriage of Clostridium difficile (the latter being present in a significant percentage of the UK population without ill effect). We will develop a flexible diagnostic platform targeted at diagnosis of CDI. Disturbances in the gut microbiome are also associated with a range of other gastrointestinal conditions including inflammatory bowel disease and colorectal cancer, and with other diseases such as diabetes. This technique therefore has wide potential application for medical diagnosis and monitoring of a range of diseases at point of care.

The realisation of high performance quantum cascade laser (QCL) sources at the short wavelength end of the 3-5 micron atmospheric transmission window is of major interest for a wide range of technological applications. Many of these are potentially of great significance for healthcare, security and the environment. However, conventional QCL materials systems such as InGaAs-AlInAs are fundamentally unsuitable for such short wavelength devices, as they do not have sufficiently deep quantum wells to support the high energy intersubband transitions required. Consequently, in recent years, attention has turned to alternative QCL materials systems based on III-V antimonides. At Sheffield we have established considerable expertise in the InGaAs-AlAsSb materials system. In addition to very deep quantum wells (~1.6 eV), this system provides lattice matched compatibility with InP-based waveguide and device fabrication technology. In this project we will develop short wavelength InGaAs-AlAsSb QCLs that will redefine the state of the art for semiconductor lasers in the 3-4 micron region, and provide unprecedented levels of performance and functionality for trace gas sensing and countermeasures applications. We will also exploit the potential of such deep QW devices for new developments in intersubband non-linear optics, in particular the demonstration of QCL operation at telecommunications wavelengths via intracavity second harmonic generation.

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

This proposal from Loughborough University outlines the case to renew the funding for the Industrial Doctorate Centre for Innovative and Collaborative Construction Engineering (CICE) as part of the Industrial Doctorate Centres call aginst the Towards Better Exploitation element of the EPSRC Delivery Plan. In partnership with an established industry base, CICE is delivering a high quality research and training programme that: meets the core technical and business needs of the construction industry; enhances its knowledge base; and produces high calibre doctoral graduates that can drive innovation. The Centre addresses a wide range of research issues that concern the UK construction industry including: Innovative Construction Technologies; Construction Business Processes; Advanced Information and Communication Technologies; Sustainable Design and Construction; and Transport and Infrastructure. Many of these areas have been highlighted in various reviews of the industry including the Latham Report, the Technology Foresight Report, the Egan Task Force Report, and more recently the National Technology Platform's research priorities. It also contributes to the EPSRC Delivery Plan as part of the knowledge transfer research and training activities. The research areas of the Centre align with the Engineering and Science for Sustainability research theme, as outlined in the EPSRC's Research Priorities and Opportunities, and fall under the 'Construction and the Built Environment' and 'Transport' sub-themes. Within the Construction and Built Environment, the Centre builds on existing strengths in the Department of Civil and Building Engineering established as part of the Engineering Doctorate Centre and other related industry based research to address some of the EPSRC research priorities to improve efficiency across the supply chain, including: encouraging the uptake of ICT to promote efficiency; improving building performance to minimise impacts on the environment ; and the analysis and design of civil engineering structures . Within the Transport area Sustainability and Innovation are key themes of the research that centres on transport operation and management, transport telematics, and minimising energy use and environmental impact . The Engineering Doctorate Centre (CICE) was established in 1999 and has subsequently recruited a total of 94 research engineers sponsored by a total of 63 large, medium and small companies. Loughborough University is a research intensive institution, which integrates its research and teaching activity at every opportunity to provide a top quality research led learning experience for all its students. The Department of Civil and Building Engineering has consistently achieved high research rating in the RAE assessments and the last RAE results were 5* in Built Environment. The Engineering Doctorate is part of Loughborough University's excellent doctoral research training programme, which in addition to supporting the pursuit of a particular project aims to provide a basic professional training to support the research and offer personal development opportunities. The training programme integrates taught and research elements tailored to suit the needs of the research engineer, project, and the sponsoring company while maintaining the expected quality of the academic standards required for a doctoral study. The Centre is managed by the Director, Prof. Dino Bouchlaghem supported by a Deputy Director, a Centre Manager and an Administrator. A Centre Management Board consisting of the Director, Deputy Director, and Industrial Representatives meets twice a year and is chaired by a senior industrialist from one of the sponsoring companies, oversees the work of the Centre and provides direction and guidance on strategic matters. This proposal has the full support of the University and has been subject to an internal review process to ensure synergy with the University's Research Strategy.