The social and economic challenges of ageing populations and chronic disease can only be met by translation of biomedical discoveries to new, innovative and cost effective treatments. The ESFRI Biological and Medical Research Infrastructures (BMS RI) underpin every step in this process; effectively joining scientific capabilities and shared services will transform the understanding of biological mechanisms and accelerate its translation into medical care. Biological and medical research that addresses the grand challenges of health and ageing span a broad range of scientific disciplines and user communities. The BMS RIs play a central, facilitating role in this groundbreaking research: inter-disciplinary biomedical and translational research requires resources from multiple research infrastructures such as biobank samples, and resources from multiple research infrastructures such as biobank samples, imaging facilities, molecular screening centres or animal models. Through a user-led approach CORBEL will develop the tools, services and data management required by cutting-edge European research projects: collectively the BMS RIs will establish a sustained foundation of collaborative scientific services for biomedical research in Europe and embed the combined infrastructure capabilities into the scientific workflow of advanced users. Furthermore CORBEL will enable the BMS RIs to support users throughout the execution of a scientific project: from planning and grant applications through to the long-term sustainable management and exploitation of research data. By harmonising user access, unifying data management, creating common ethical and legal services, and offering joint innovation support CORBEL will establish and support a new model for biological and medical research in Europe. The BMS RI joint platform will visibly reduce redundancy and simplify project management and transform the ability of users to deliver advanced, cross-disciplinary research.

Research infrastructures (RIs) operate in complex innovation ecosystems where industry plays an increasingly important role. Pan-EU initiatives, such as the Innovation Union or the European Strategy Forum on Research Infrastructures, revolutionise the way public and private sectors work together, and help to create structural frameworks which are needed to foster such collaborations. While initiatives of this type play a crucial role in enabling industry to become a full partner of research infrastructures whether it is as a user, a supplier, or a co-creator, they do not fully utilise or engage Industrial Liaison and Contact Officers (ILOs/ICOs) which could have a central role in boosting the RI-industry partnerships. To address this gap, ENRIITC will build a permanent pan-European network of ILOs and ICOs. This will be done in a community-driven, cross-functional, cross-sectoral, multiplier-based way which will be inclusive and enable all interested parties to actively participate. By supporting the establishment of strategic, cross-border partnerships between industry and research infrastructures, ENRIITC will enable win-win results for all parties. With a timeline of 36 months, 11 partners from seven countries, and a strong support from 61 Associates from around Europe, ENRIITC will 1) establish a sustainable European network of ILOs and ICOs which enables mutual learning, 2) map collaboration potential between research infrastructures and industry, 3) develop and refine strategies and best practices to foster these collaborations, 4) raise awareness among industry for collaboration opportunities at research infrastructures, and demonstrate impact. The consortium and Associates will jointly balance the need for expertise from diverse scientific areas, combine it with practical insights from establishing relations with various industries operating in different sectors and geographical contexts, and propagate it among their networks.

The ambition of AtlantECO is to develop and apply a novel, unifying framework for providing knowledge-based resources to design policies, support decisions making and engage with citizens to encourage responsible behaviour to manage the Atlantic system and protect its Ecosystem Services (ES) provision. The aim of AtlantECO is to determine the structure and function of Atlantic microbiome in the context of ocean circulation and presence of pollutants, e.g., plastics, to assess its role in driving the dynamics of Atlantic ecosystems at basin and regional scales; its potential of being used as a sensor of ecosystem state and the mechanisms by which it drives the provision of 5ES. This is key to improve our predictions on future provision of ES in the basin and to favour the establishment of a sustainable Blue Growth strategy for an All-Atlantic community. To realise this vision, AtlantECO has four objectives which are to 1) Assess dynamics of Atlantic marine ecosystems, their ES provision and the interplay of both with socio-economic activities; 2 increase knowledge and data on microbiomes, plastics, the plastisphere and carbon fluxes that support ecosystems at basin scale using best practices and integrative sampling strategies, novel genomics, imaging and biogeochemical methods, bioinformatics and modelling approaches; 3) Assess and predict the cumulative impacts of multiple stressors on ecosystem status and dynamics and ES provision, identifying their drivers and role on tipping points, assessing their changes in recovery of ecosystem structures, functions and services, and developing eco-socio-economic models to predict future trajectories and 4) Deploy a systemic strategy to build capacity and transfer knowledge for a seamless engagement between science, industry, policy, and society. To achieve these objectives AtlantECO brings together experts and pioneers from Europe, South America and South Africa with the relevant resources, knowledge and experience.

Seagrass meadows are among the most productive marine ecosystems, playing essential structural and functional roles, and are recognized as the most efficient blue carbon sinks globally. The plant-associated microbiome, a diverse array of microbial taxa forming intimate symbiotic relationships with seagrasses, is critical for maintaining ecosystem stability and facilitating plant adaptation to environmental stressors. In the Mediterranean Sea, however, the endemic seagrass Posidonia oceanica is in decline due to climate change-driven stressors, particularly thermal stress. The sponge Chondrilla nucula is commonly found in association with P. oceanica, and it is hypothesized that this sponge-plant symbiosis enhances the metabolic capabilities of both organisms, mediated by key microbial communities, especially under thermal stress. Despite this potential, the precise dynamics of nutrient exchange and interactions between seagrasses and sponges, facilitated by their microbiomes, remain poorly understood. This knowledge gap limits our ability to fully comprehend the ecological and metabolic functions of these associations and hinders the development of nature-based solutions to mitigate the impacts of climate change. MicroSymb aims to address this gap by studying the P. oceanica–C. nucula association through their microbiomes, utilizing field sampling, mesocosm and stable isotope probing experiments, metabarcoding, and meta-omics approaches. This project will evaluate the capacity of this association to adapt and remain resilient in the face of ocean warming. Throughout MicroSymb, I will acquire advanced skills in metagenomics, metaproteomics, and nutrient cycling within holobionts, while contributing my expertise in marine ecology, host-microbiome interactions, holobiont functioning, molecular biology, and bioinformatics. MicroSymb will position me at the forefront of host-microbiome research and the study of adaptive capacities in marine organisms amid climate change.