The project CanBioSe targeted to strengthen international and intersectoral collaboration, sharing new ideas and knowledge transfer from research to market and vice versa in the field of nanostructured metal oxide optical biosensors for cancer cells detection. Interdisciplinary project research and innovation goals are targeted to develop a new portable tool for early stage cancer detection which can solve on of important health challenges in EU society. One dimensional (1D) polimer nanofibers will be deposited by electrospinning technique. Photonic nanomaterials, based on metal oxide based nanostructures (ZnO, ZnO/Al2O3 nanolaminates, Au/ZnO and ZnO/Au) will coat the 1D nanofibers. Metal oxides and Au nanoparticles will be deposited with Atomic Layer Deposition (ALD) and electrophoresis, respectively. Bioselective layer will be formed by immobilization of specific antibodies on the biosensor surface. Photoluminescence and optical spectroscopy will be used for recording of the biosensor signal. Biosensor testing will be performed on cancer cells (human chronic lymphocyte leukemia (CLL) leucosis and acute lymphoblastic leucosis). The biosensor will be integrated with microfluidic system in order to minimize dimensions and simplify the use of the detection system. The project partners will provide research and training activities in the fields of nanotechnology, surface functionalization, bioengineering, microfluidics and biosensor testing, market analysis and commercialization. Provided research and management training to experienced researchers and early stage researchers will strengthen their personal skills and CVs via new scientific papers and conference theses and strengthen a development of EU research human resources. Long lasting collaboration between partners, based on co-supervising students and preparation of novel collaborative project proposals is foreseen. Dissemination of the project results to scientific society and wide auditories is foreseen.

A huge percentage of the recent European cultural heritage (CH) can be found in movies, photographies, posters and slides produced between 1895 and 1970 were made using cellulose derivates. More than 75 years of visual and audio memories are in serious danger to be lost due to the natural instability cellulose acetate (CA) and Cellulose nitrate (CN) materials. These physical media have helped to preserve the cultural material that is a real witness of socio-cultural European evolution in the recent era. It encompasses the possibility to understand the development of new arts such as cinema, photography or graphic arts and also the preservation of the socio-cultural memories of citizens located in major and local museums worldwide. Conservators consider two approaches when planning treatments to extend the useful lifetime of cultural materials: preventive or passive and active or interventive. But in case of cellulose derivates and other components of the movie or photos, once initiated, degradation cannot be prevented, reversed or stopped, but only inhibited or slowed. Inhibitive conservation of cellulose derivates can either involve the removal or reduction of factors causing degradation including light, oxygen, acids, fungus and relative humidity among others, as well as cost-sensitive processes such as freeze. NEMOSINE improves the traditional storage solutions, such as freeze storage (below 5ºC), by developing an innovative package with the main goal of energy saving and extent conservation time. NEMOSINE will develop: i) High O2 barrier and Active packaging using non-odour additives, ii) Active acid adsorbers based on functionalized Metal Organic Framework (MOFs) integrated in innovative structures, iii) Gas detection sensors to monitoring AA, O2 & NO, iv) Multi-scale modelling to correlate degradation & sensors signals, v)Packaging with modular design to fulfil the technical & economical requirements of the different CH made by cellulose derivates.