The incidence of Cardiovascular Disease (CD) claims worldwide 17.1 million lives a year, with an estimated 31% of all deaths globally and a EU cost of 139 billion euros. Up to 40% of all deaths occur among the elderly. In spite of all medical efforts, the 5-year mortality was reduced significantly less than that of malignant diseases. This highlights the urgent need to overcome the difficulties associated with present pharmacological therapies (i.e. drug instability, and unspecific targeting) by developing new ground-breaking therapeutic strategies that go far beyond any current regimens. New approaches for safe, efficient, and heart-specific delivery of therapeutics are strongly required. CUPIDO is envisioned to meet these critical needs by providing an unconventional and effective strategy based on nanoparticle-assisted delivery of clinically available and novel therapeutics to the diseased heart. In particular, CUPIDO will develop innovative bioinspired hybrid nanoparticles formulated as biologicals delivery, which are i) biocompatible and biodegradable, ii) designed for crossing biological barriers, and iii) guidable to the heart. A combination of multidisciplinary manufacturing and validation approaches will be employed, bringing the envisioned product beyond the currently available clinical and day-to-day management of CD individuals. Scale-up production, and respect of medical regulatory requirements will allow CUPIDO to deliver a final product for future late pre-clinical and clinical studies. Altogether, CUPIDO will foster the translation of nanomedical applications toward the cardiac field, which although still in its start, offers great potential to overcome the limitations associated to the currently pharmacological treatments.

The advancement of direct solar fuel technologies is key to provide a sustainable, secure energy supply for the EU and other global regions, and for the challenging-to-electrify aviation and maritime sectors. State-of-the-art technologies for solar fuel production (including natural photosynthesis) suffer from low solar-to-fuel conversion efficiency, low production rates and prohibitively high costs. Within the framework of SUN-PERFORM, we will address these critical limitations through an innovative biohybrid approach based on innovations in nanotechnology and synthetic biology. SUN-PERFORM aims to: 1) to develop artificial nanocrystal light-harvesting systems, to efficiently harvest a larger part of the solar light spectrum, 2) to generate advanced microalgal solar cell factories, by introducing synthetic pathways for a more efficient, rapid conversion of light energy and CO2 into lipid fuel precursors. Microalgal lipids are promising hydrocarbons for fuels, being already approved production pathways for Sustainable Aviation Fuel. However, current lipid production is still too inefficient and slow, hindering the cost-effective generation of renewable fuels. Through the implementation and integration of groundbreaking innovations at a pilot scale, SUN-PERFORM aims to achieve a remarkable four-fold increase in the existing solar-to-fuel efficiency. This will be demonstrated across two case studies reflecting the different solar irradiances received in Europe and Africa. In addition to technical advancements, SUN-PERFORM will comprehensively evaluate the sustainability, techno-economic and social aspects of this novel route, to guide its development as a truly sustainable, secure and affordable production platform. Diverse stakeholders, including industry and several partners in Africa, will be involved in SUN-PERFORM to support the global development and the European leadership and export position for solar fuel technology.

There is an increasing demand for advanced materials with temperature capability in highly corrosive environments for aerospace. Rocket nozzles of solid/hybrid rocket motors must survive harsh thermochemical and mechanical environments produced by high performance solid propellants (2700-3500°C). Thermal protection systems (TPS) for space vehicles flying at Mach 7 must withstand projected service temperatures up to 2500°C associated to convective heat fluxes up to 15 MWm-2 and intense mechanical vibrations at launch and re-entry into Earth’s atmosphere. The combination of extremely hot temperatures, chemically aggressive environments and rapid heating/cooling is beyond the capabilities of current materials. Main purpose of C3HARME is to design, develop, manufacture, test and validate a new class of out-performing, reliable, cost-effective and scalable Ultra High Temperature Ceramic Matrix Composites (UHTCMCs) based on C or SiC fibres/preforms enriched with ultra-high temperature ceramics (UHTCs) capable of in-situ repairing damage induced during operation in severe aerospace environments. C3HARME will apply to two main applications: near-ZERO erosion rocket nozzles that must maintain dimensional stability during firing in combustion chambers, and near-ZERO ablation thermal protection systems enabling hypersonic space vehicles to maintain flight performance. C3HARME represents a well-balanced mix of innovative and consolidated technologies, mitigating the level of risk intrinsic in top-notch research and innovation development. C3HARME starts from TRL of 3-4 and focuses on TRL 6 thanks to a strong industrial partnership, including SMEs and large companies. To reach TRL 6, rocket nozzles and TPS tiles with realistic dimensions and shape will be fabricated, assembled into a suitable system, and validated in a relevant ambient (environment centered test). Project results could be easily extended to the energy, medical and/or nuclear environments.

Cultivation of plants consumes huge resources of water for irrigation and energy for lighting. Introducing disruptive technologies is key to improve plants and enable their parsimonious cultivation. DREAM overtakes these challenges by gathering an interdisciplinary consortium sharing a same radical vision: to measure and exploit the dynamics of photosynthesis regulation under natural-like light conditions for selective sensing – monitoring the plant state – and enhancing lighting efficiency in controlled environments. We develop ground-breaking instruments and acquisition protocols unraveling unprecedented kinetic data from microalgae and plants (including tomato as a crop species) by using novel periodically modulated or randomly fluctuating illuminations, chlorophyll fluorescence, and original luminescent nanosensors. These data are processed with comprehensive theoretical tools (system identification, dynamical systems, system control, machine learning) to build a powerful dynamical model which delivers categorizing fingerprints for highly selective sensing and tailored modulated illuminations for enhancing lighting efficiency. Finally, we implement a server with incremental learning from an open source community to extend sensing to organisms and environmental conditions much beyond the ones used in our DREAM project. DREAM will expand knowledge on photosynthesis regulation and lead to major achievements: categorizing plant states (sensing stresses, selecting improved plants), improving controlled ecosystems (equipping lighting with sensing and decreasing its cost), and instrument design (targeting scientists and many more end-users). DREAM will further improve innovation in key European industries active in the fields of scientific instruments, phenotyping, and plant production while increasing resource use efficiency so as to improve environmental quality and offer better and safer products to consumers.