The GRACE integrated solution aims to transform the healthcare ecosystem by providing essential knowledge and innovative public-private partnership for (1) reorganizing healthcare services (2) with embedded innovative technologies and tools, helping identifying and overcoming barriers and gaps that are now hindering CVD management, ensuring a seamless continuum of care and optimized care pathways. Our vision is that introducing effective health technology and interventions is economically, societally and environmentally sustainable if and only accompanied by a substantial healthcare service re-organization. Accordingly, GRACE will focus on an end-to-end clinical pathway CVD, considering an holistic view of the patient and optimizing healthcare services leveraging on advanced technological solutions. GRACE intervention will be multifold aiming at: (1) guiding strategic policies, (2) drive market innovation, and (3) foster effective healthcare delivery practices in CVD, generating value for patients, healthcare workers and system. GRACE will enable early and personalized interventions, fostering coordination of multidiscipline healthcare teams, triggering more intense and person-specific management using innovative technologies, AI and digital solutions for early detection of red flags, promoting patient empowerment, while comprehensively containing CVD risk factors and burden. A multidisciplinary consortium of experienced and competitive partners will implement this vision and implement the proposed solution in a novel multidiscipline manner.