ePIcenter will create an interoperable cloud-based ecosystem of user-friendly extensible Artificial Intelligence-based logistics software solutions and supporting methodologies that will enable all players in global trade and international authorities to co-operate with ports, logistics companies and shippers, and to react in an agile way to volatile political and market changes and to major climate shifts impacting traditional freight routes. This will address the ever-increasing expectations of 21st century consumers for cheaper and more readily available goods and bring in Innovations in transport, such as hyperloops, autonomous/robotic systems (e.g. “T-pods”) and new last-mile solutions as well as technological initiatives such as blockchain, increased digitalisation, single windows, EGNOS positional precision and the Copernicus Earth Observation Programme. ePIcenter thus addresses MG-2-9-2019 of H2020 Mobility for Growth “InCo Flagship on Integrated multimodal, low-emission freight transport systems and logistics”, particularly in what refers to new logistics concepts, new disruptive technologies, new trade routes (including arctic routes and new Silk routes) and multimodal transfer zones. ePIcenter will speed up the path to a Physical Internet and will benefit peripheral regions and landlocked developing countries. ePIcenter will reduce fuel usage (and corresponding emissions) by 10-25%, lead to greater utilisation of greener modes of transport reducing long distance movements by trucks by 20-25% and ensure a smoother profile of arrivals at ports which will reduce congestion and waiting/turnaround times.