Glioma is an extremely lethal cancer, due largely to the inaccessible nature of the brain and diffusion of cells from the tumour site. These diffuse cells are usually too deeply embedded in the brain to safely remove by current means. Targeted Reactive Oxygen Species (ROS) generation is a promising form of glioma treatment to selectively eliminate glioma, including diffuse cells. However, the only current means of targeted ROS generation is photodynamic therapy (PDT) which generates ROS using expensive and potentially toxic photosensitisers (PS) which are ineffective against distant diffused cells and introduce many treatment limitations. GlioLighT proposes a novel alternative form of targeted ROS generation: Direct Light Therapy (DLT). DLT uses 1267nm light to generate 1O2 species in glioma cells without dependency on a PS. The removal of PS will revolutionise glioma treatment, enabling novel treatment modalities to vastly improve efficacy, earlier intervention options, all at reduced cost and complexity. However, whilst the principles of DLT have been demonstrated, little is known about how DLT achieves its anti-cancer effects, or the extent of its therapeutic benefits. Leveraging decades of accumulated PDT knowledge and technology development, GlioLighT will study DLT technology both independently and compared to PDT. The effect of DLT on glioma and the brain, focusing on immunogenicity, will be studied to determine DLT’s efficacy, safety, and mechanisms of action. Novel ultrashort pulse (USP) light sources will be developed to maximise optical penetration and minimise safety risk, ensuring DLT is suited for clinical adoption. Lastly, the development of the preclinical GlioLighT delivery and sensing system (pcGlio-DSS) ready for the next steps of clinical translation, will bring DLT a leap closer to vastly improving glioma treatment in Europe and worldwide.

Current driver assistance systems are not all-weather capable. They offer comfort and safety in sound environmental conditions. However, in adverse weather conditions where the accident risks are highest they malfunction or even fail. Now that we are progressing towards automated cars and work machines, the requirements of fully reliable environment perception are only accentuated. The project is focusing on automated driving and its key enabling technology, environment perception. Consequently, project’s main objective is to develop and validate an all-weather sensor suit for traffic services, driver assistance and automated driving. Extended driving environment perception capability with smart, reliable and cost-efficient sensing system is necessary to meet the targets of all future driver assistance system applications. These targets need to be met regardless of location, weather or time of the day. Only by means of reliable and robust sensing system upcoming automated driving will be possible. The new sensor suit is based on a smart integration of three different technologies: (i) Radio radar, 77 GHz-81 GHz, (MIMO Radar); (ii) Gated short wave infrared camera with pulsed laser illumination (SWIR camera)and (iii) Short-wave infrared LIDAR (SWIR Lidar). Such a full fusion approach has never been investigated before, so that the outcome will advance the state-of-the-art significantly and demonstrate the potential of all-weather environment perception. DENSE innovation lies in the provision of a brilliant restored enriched colour image from a degraded infrared image and consequently, this is followed by a variety of application fields for low cost solutions. An important aim is also to close the gap to US developments in the field and avoid their restrictions for selling components overseas for strategic reasons and strengthen the position of European industry in worldwide competition.