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  • Detection of functional divergence in human protein families. Cube-DB is a database of pre-evaluated conservation and specialization scores for residues in paralogous proteins belonging to multi-member families of human proteins. Protein family classification follows (largely) the classification suggested by HUGO Gene Nomenclature Committee. Sets of orthologous protein sequences were generated by mutual-best-hit strategy using full vertebrate genomes available in Ensembl. The scores, described on documentation page, are assigned to each individual residue in a protein, and presented in the form of a table (html or downloadable xls formats) and mapped, when appropriate, onto the related structure (Jmol, Pymol, Chimera).

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  • Reports and articles from RIVM

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  • BRCA Share is a novel gene datashare initiative that provides scientists and commercial laboratory organizations around the world with open access to BRCA Share (formerly UMD-BRCA1) contains BRCA1 and BRCA2 genetic data. The program’s goal is to accelerate research on BRCA gene mutations, particularly variants of uncertain significance, to improve the ability of clinical laboratory diagnostics to predict which individuals are at risk of developing these cancers.

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  • Natural products, also known as specialized or secondary metabolites, are small molecules produced by many organisms. These chemical compounds often show strong biological activities, making them interesting for medicine, agriculture, and other fields. Their biosynthesis is governed by a set of enzymes, which can be separated into gatekeeper/core enzymes, and tailoring enzymes. The latter modify the nascent natural products, giving them their final form, and often confer their biological activity. Tailoring enzymes show a wide range of substrate- and reaction-specificities. The Minimum Information about a Tailoring Enzyme (MITE) data standard was created to facilitate consistent and systematic deposition and retrieval of data on tailoring enzymes. Each MITE entry contains information on a single enzyme: its reaction(s), substrate specificities, known substrate-product pairs, and additional metadata. This record describes the data repository accompanying the data standard.

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  • TreeBASE is a repository of phylogenetic information, specifically user-submitted phylogenetic trees and the data used to generate them. TreeBASE accepts all types of phylogenetic data (e.g., trees of species, trees of populations, trees of genes) representing all biotic taxa. TreeBASE is temporarily offline except to provide access to editors/curators, as security updates are required before re-publishing the site.

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1,891 Data sources
  • Detection of functional divergence in human protein families. Cube-DB is a database of pre-evaluated conservation and specialization scores for residues in paralogous proteins belonging to multi-member families of human proteins. Protein family classification follows (largely) the classification suggested by HUGO Gene Nomenclature Committee. Sets of orthologous protein sequences were generated by mutual-best-hit strategy using full vertebrate genomes available in Ensembl. The scores, described on documentation page, are assigned to each individual residue in a protein, and presented in the form of a table (html or downloadable xls formats) and mapped, when appropriate, onto the related structure (Jmol, Pymol, Chimera).

    more_vert
  • more_vert
  • Reports and articles from RIVM

    more_vert
  • more_vert
  • more_vert
  • BRCA Share is a novel gene datashare initiative that provides scientists and commercial laboratory organizations around the world with open access to BRCA Share (formerly UMD-BRCA1) contains BRCA1 and BRCA2 genetic data. The program’s goal is to accelerate research on BRCA gene mutations, particularly variants of uncertain significance, to improve the ability of clinical laboratory diagnostics to predict which individuals are at risk of developing these cancers.

    more_vert
  • more_vert
  • Natural products, also known as specialized or secondary metabolites, are small molecules produced by many organisms. These chemical compounds often show strong biological activities, making them interesting for medicine, agriculture, and other fields. Their biosynthesis is governed by a set of enzymes, which can be separated into gatekeeper/core enzymes, and tailoring enzymes. The latter modify the nascent natural products, giving them their final form, and often confer their biological activity. Tailoring enzymes show a wide range of substrate- and reaction-specificities. The Minimum Information about a Tailoring Enzyme (MITE) data standard was created to facilitate consistent and systematic deposition and retrieval of data on tailoring enzymes. Each MITE entry contains information on a single enzyme: its reaction(s), substrate specificities, known substrate-product pairs, and additional metadata. This record describes the data repository accompanying the data standard.

    more_vert
  • TreeBASE is a repository of phylogenetic information, specifically user-submitted phylogenetic trees and the data used to generate them. TreeBASE accepts all types of phylogenetic data (e.g., trees of species, trees of populations, trees of genes) representing all biotic taxa. TreeBASE is temporarily offline except to provide access to editors/curators, as security updates are required before re-publishing the site.

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