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FerrDb V2 contains 1001 ferroptosis regulators and 143 ferroptosis-disease associations manually curated from 3288 articles. Specifically, there are 621 gene regulators, of which 264 are drivers, 238 are suppressors, 9 are markers, and 110 are unclassified genes; and there are 380 substance regulators, with 201 inducers and 179 inhibitors. Compared to FerrDb V1, curated articles increase by > 300%, ferroptosis regulators increase by 175%, and ferroptosis-disease associations increase by 50.5%. Circular RNA and pseudogene are novel regulators in FerrDb V2, and the percentage of non-coding RNA increases from 7.3% to 13.6%. External gene-related data were integrated, enabling thought-provoking and gene-oriented analysis in FerrDb V2.
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China National GeneBank DataBase (CNGBdb) is an official partner of the GISAID Initiative. It provides access to EpiCoV and features the most complete collection of hCoV-19 genome sequences along with related clinical and epidemiological data. With the data from this database scientific researchers can construct a virus phylogenetic tree to reveal the characteristics of the pathogen, and provide effective references for the study and analysis of the evolutionary source and pathological mechanism of the novel coronavirus.
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Paramecia are unicellular eukaryotes of large size (~ 120 micrometers for P aurelia species) that belong to the ciliate phylum. Ciliates, like the Last Eukaryotic Common Ancestor, have the axonemal structure in the form of vibrating cilia that assure locomotion and food capture and are essential for pairing of paramecia of opposite mating types during conjugation (sexual reproduction). Like multicellular eukaryotes, ciliates separate germinal and somatic functions, harbouring two different kinds of nuclei. A diploid germinal micronucleus transmits the genetic information to the next sexual generation, while a polyploid somatic macronucleus is responsible for gene expression. Reproducible DNA elimination, which occurs in many animal lineages, takes place in ciliates during sexual reproduction, when a new somatic macronucleus develops from a copy of the germline micronucleus. The somatic genomes of numerous Paramecium species are being sequenced and annotated. ParameciumDB integrates the genomes as they become available, to provide resources for functional and comparative genomics to the community. ParameciumDB interfaces and tools have been redesigned. Your feedback is welcome.
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- Data Repository France Compatibility:collected from a compatible aggregatorPartners:CNRS, Université de Strasbourg, CNRS, INSU Natural Sciences, Physics, Astrophysics and AstronomyCNRS,Université de Strasbourg,CNRS, INSUAll Research products
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FerrDb V2 contains 1001 ferroptosis regulators and 143 ferroptosis-disease associations manually curated from 3288 articles. Specifically, there are 621 gene regulators, of which 264 are drivers, 238 are suppressors, 9 are markers, and 110 are unclassified genes; and there are 380 substance regulators, with 201 inducers and 179 inhibitors. Compared to FerrDb V1, curated articles increase by > 300%, ferroptosis regulators increase by 175%, and ferroptosis-disease associations increase by 50.5%. Circular RNA and pseudogene are novel regulators in FerrDb V2, and the percentage of non-coding RNA increases from 7.3% to 13.6%. External gene-related data were integrated, enabling thought-provoking and gene-oriented analysis in FerrDb V2.
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China National GeneBank DataBase (CNGBdb) is an official partner of the GISAID Initiative. It provides access to EpiCoV and features the most complete collection of hCoV-19 genome sequences along with related clinical and epidemiological data. With the data from this database scientific researchers can construct a virus phylogenetic tree to reveal the characteristics of the pathogen, and provide effective references for the study and analysis of the evolutionary source and pathological mechanism of the novel coronavirus.
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Paramecia are unicellular eukaryotes of large size (~ 120 micrometers for P aurelia species) that belong to the ciliate phylum. Ciliates, like the Last Eukaryotic Common Ancestor, have the axonemal structure in the form of vibrating cilia that assure locomotion and food capture and are essential for pairing of paramecia of opposite mating types during conjugation (sexual reproduction). Like multicellular eukaryotes, ciliates separate germinal and somatic functions, harbouring two different kinds of nuclei. A diploid germinal micronucleus transmits the genetic information to the next sexual generation, while a polyploid somatic macronucleus is responsible for gene expression. Reproducible DNA elimination, which occurs in many animal lineages, takes place in ciliates during sexual reproduction, when a new somatic macronucleus develops from a copy of the germline micronucleus. The somatic genomes of numerous Paramecium species are being sequenced and annotated. ParameciumDB integrates the genomes as they become available, to provide resources for functional and comparative genomics to the community. ParameciumDB interfaces and tools have been redesigned. Your feedback is welcome.
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