Addictions to psychoactive substances generate a growing public health concern and represent a significant financial burden. Efforts should thus be made to understand how addictive behavior settles in order to ultimately define strategies to prevent such pathological process. Despite identified brain structures and synaptic circuit underlying addictive behavior, our understanding of the cellular substrate underlying changes in the treatment of information that lead to addiction remain incomplete. Neuroglial interactions have recently been showed to markedly partake in brain information processing and cognitive functions. However, how they participate to the rewiring leading to addiction is unresolved. Our recent dataset show that the astroglial protein Cx30 is strongly involved in the response to cocaine exposure. Interestingly, Cx30 bears multiple functions that may all influence the plastic changes associated with addiction. Namely, its channel function that can regulate levels of small molecules such as dopamine as well as its role in shaping extracellular matrix proteins or coverage of glutamatergic synapses. The current project therefore aims at understanding how astroglial Cx30 takes part in the development of addictive behavior toward cocaine. To this end, the objectives of the current project are threefold: 1- Ascertain the implication of Cx30 in the development, persistence and relapse to addictive behavior 2- Decipher the physiopathological processes at play and controlled by astrocytes in cocaine addiction 3- Identify the astroglial pathway(s) underlying Cx30 control of addiction. Unraveling how neuroglial interactions influence cerebral functions will provide a more comprehensive framework for identifying dysfunctions underlying brain disorders as well as novel therapeutic targets.