Smart4Health will enable the citizen-centred EU EHR exchange for personalised health. This will pave the way for the full deployment of citizen-centred solutions and services in a digital single market for wellbeing and healthcare. It will provide for interoperability, complementarity and cooperativity with profiles that are currently used e.g. by Member States and regions. Smart4Health will enable the bridging between the diverse EU EHR data and citizen-generated health data. It will connect citizens to science and personalised health services. The European Commission 2017 review of the Digital Single Market lists three priorities: 1) Citizens´ secure access to electronic health records and the possibility to share it across borders, 2) Supporting data infrastructure, to advance research, disease prevention and personalised health and care 3) Facilitating feedback and interaction between patients and healthcare providers, to support prevention and citizen empowerment as well as quality and patient-centred care. Smart4Health addresses these priorities with an outstanding consortium that develops, tests and validates a platform prototype for the Smart4Health citizen-centred health record EU-EHR exchange. Smart4Health provides an easy-to-use, secure, constantly accessible and portable health data and services prototype, thus advancing citizen health and wellbeing, and digital health innovation. Smart4Health builds on the strength of the European infrastructures CEF, ELIXIR, the EIT Health, BBMRI-ERIC, the European Virtual Laboratory for Enterprise Interoperability (I-VLab), the experience and knowledge gained and generated, the EU/US collaboration in eHealth, e.g. the Icahn School of Medicine at Mount Sinai, the momentum of initiatives in the Member States, e.g. 'Medizininformatik Initiative' of the BMBF in Germany. Smart4Health enables citizens to manage and bridge their own health data throughout the EU and beyond, advancing own and societal health and wellbeing.