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University of Bern
Country: Switzerland
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322 Projects, page 1 of 65
  • Funder: EC Project Code: 101027428
    Overall Budget: 203,149 EURFunder Contribution: 203,149 EUR

    Nicotinic acetylcholine receptors (nAChRs) are transmembrane ligand gated ion channels composed of five subunits and encoded by 16 genes. Depending on the subunit composition nAChRs have different properties and functions. It is widely accepted that smoking tobacco is correlated with several types of cancers and that nicotine and tobacco-derived nitrosamines are known to activate nAChRs contributing to oncogenic processes. To date the question of whether nAChRs contribute to the cellular malfunctions involved in prostate and colon cancer still remains unanswered. Our preliminary results show for the first-time different expression levels of nAChRs subunits in prostate and colon cancer cell lines. Most strikingly is the clear difference of expression of nAChRs subunits between cancerous vs. non-cancerous cells, depending on the aggressiveness and cell type. The question arises whether these differences have a physiological impact. In the present project I will investigate the pathophysiological role of nAChRs in prostate and colorectal cancer. My aim is to (1) Identify and characterize nAChRs involved in prostate and colon cancer; (2) study the role of nAChRs in migration, proliferation and invasion in prostate and colon cancer; (3) the influence of a duplicated isoform of the α7 nAChR subunit, dupα7, and its anti-angiogenic properties in CRC and PCa; and (4) the role of chemotherapeutic drugs, which could augment nAChRs expression in cancer and contribute to chemoresistance. The present project will be performed at the laboratory of Dr. Peinelt University of Bern, an established research group with a focus on the pathophysiology of ion channels in prostate and colorectal cancer and in collaboration with the Urology Department of the University Hospital Inselspital Bern. The Marie Curie IF will help me to further develop leadership skills, scientific maturity and independence and will be crucial for my aim to obtain an independent academic position in the future.

  • Funder: EC Project Code: 842868
    Overall Budget: 191,149 EURFunder Contribution: 191,149 EUR

    PROSPER is an interdisciplinary project that seeks to understand the politics of rule-making in the global trade regime. It primarily aims to examine how the growth of internationalization of production networks enables private actors – i.e. multinational companies (MNCs) – to be active in the shaping of international economic policies, such as trade agreements and regulatory standards. PROSPER will primarily investigate the extent to which MNCs are able to orchestrate political mobilization of their subsidiaries for coordinated lobbying and impose rules and standards upon firms along their supply chains. Applying international political economy (IPE) insights from the fields of political science, economics, and international law, the projects proposes that firms’ globalization strategies and their degree of integration into global production networks significantly affect their ability to be active in shaping global rules and standards. In order to test the empirical implications of the proposed theory, PROSPER will employ a mixed-method research design using quantitative analysis and in-depth case studies. The project will construct a comprehensive new dataset of MNCs and triangulate the results achieved through statistical analysis via comparative cases studies. As a result, by combining insights from political science, economics, and international law, the project will help us understand the dynamics of economic globalization and the role of private actors in the global trade governance.

  • Funder: EC Project Code: 744257
    Overall Budget: 187,420 EURFunder Contribution: 187,420 EUR

    Recently, it has emerged that early life exposure to commensal microbes is crucial to instruct our immune system and prevent later life autoimmune and metabolic diseases. The host lab now showed that this education begins even earlier – during gestation by signals from the maternal intestinal microbiota. Using the E. coli strain HA 107, genetically engineered to grow in vitro without the ability to persist in vivo, they demonstrated that transient intestinal colonisation of pregnant germ-free mouse dams drives neonatal innate immune maturation. However, the long-term consequences of maternal microbiota cues especially for the adaptive immune system of the adult offspring remain elusive. The MEMORIS project (Maternal Enteric Microbiota for Offspring's Repertoire development & Illness Susceptibility) shall elucidate the long-term consequences of maternal microbial signals for the offspring’s adaptive immune system and disease susceptibility. My specific aims are to reveal the consequences of gestational colonisation for the offspring’s (1) own intestinal microbiota composition and metabolism; (2) adaptive immune repertoire development; and (3) susceptibility to autoimmune and metabolic diseases. For this, I will colonise offspring of gestationally colonised versus germ-free mouse dams at birth and by (1) metagenomic, metatranscriptomic and metabolomic read-outs assess its dynamic microbiota development. (2) Flow cytometric and transcriptional profiling, immunglobulin gene sequencing and bacterial FACS will reveal adaptive immune repertoire maturation. Based on these results I will (3) elucidate the role of maternal microbiota signals for disease susceptibility using NOD mice modeling type 1 diabetes and high fat diet-induced non-alcoholic fatty liver disease. I would like to establish the concept that our susceptibility to autoimmune and metabolic diseases is influenced during a “window of opportunity” that opens – not just at birth – but already during pregnancy.

  • Funder: EC Project Code: 743290
    Overall Budget: 187,420 EURFunder Contribution: 187,420 EUR

    Despite the existence of various novel anti-cancer treatments, drug resistance remains a major cause of death in patients with disseminated cancer. To increase specificity and efficacy, modern treatment strategies in molecular oncology employ the “synthetic lethality” concept. An example are BRCA1/2-deficient breast and ovarian cancers that lack DNA repair by homologous recombination (HR). Due to this defect, tumor cells rely more on other DNA repair pathways. When such alternative pathways are jammed, e.g. by poly(ADP-ribose) polymerase inhibitors (PARPi), normal cells with intact HR can survive, whereas cancer cells die. However, even with this sophisticated treatment strategy, resistance to PARPi still occurs and greatly reduces patient survival. The mechanisms driving this resistance are still largely unknown. The main goal of this project is to advance the knowledge on therapy resistance by using a genetically engineered mouse model of BRCA2-deficient breast cancer, which closely mimics the human disease. Like in patients, cancer cells in these animals eventually escape from therapy. I will start by synergizing the next generation sequencing analysis of spontaneous resistant mouse tumors with functional genetic screens using the CRISPR/Cas9 technology. This combination has yielded interesting candidate genes whose loss of function may cause resistance. Two promising candidates, MDC1 and Claspin, will be further investigated using innovative and physiologically relevant 3D tumor organoid cultures. Moreover, I will apply my expertise in modern imaging technology to develop novel approaches to visualize DNA repair dynamics in resistant tumors in vitro and in vivo. I am convinced that by understanding basic resistance mechanisms, smart biosensors can be built to image the DNA damage response and eventually improve clinical decision making. I believe this project will have an impact on the design of strategies to overcome therapy escape in human cancer patients.

  • Funder: EC Project Code: 833366
    Overall Budget: 304,724 EURFunder Contribution: 304,724 EUR

    During the 19th century, several music and choral societies arose in Europe, giving rise to a choral movement that fostered not only communal singing, but also patriotic feelings. In Switzerland, this movement involved several men’s choirs that had a strong liberal and patriotic character. This patriotism, however, could not be based on cultural, linguistic or ethnic unity, but called for the integration of the four cultures that make up Switzerland. With its songs and festivals, the Swiss choral movement became a crucial element in this integration process. Yet despite its significance, this movement remains largely ignored by recent scholarship. There is a lack of research on the movement as a whole and principally of specific knowledge about the choral life in different places. The cities of Bern and Fribourg for example have different languages, religions and traditions. To what extent did their choral life differ from or resemble one another? By answering this question, CLEFNI aims to understand how choral activities influenced the social and political life in these cities and contributed to the integration of the Swiss peoples. The objective is to better understand the historical circumstances and the specific conditions that allowed integration and multicultural understanding. CLEFNI is designed as an archival research and will critically analyse sources in archives of 19th-century choral societies in terms of their musical, social and political contexts and of their gender dimensions. Findings will then be discussed in view of existing research on the 19th-century choral movement, on musicology and on related disciplines like sociology and history. Considering that multicultural understanding continues to be a challenge in Europe, CLEFNI’s value goes beyond the Swiss borders, providing new knowledge that contributes to understanding how cultural movements like choral singing may lead to multicultural understanding and integration of cultural minorities.


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