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Increased efforts are required to prevent further losses to terrestrial biodiversity and the ecosystem services that it provides1,2. Ambitious targets have been proposed, such as reversing the declining trends in biodiversity3; however, just feeding the growing human population will make this a challenge4. Here we use an ensemble of land-use and biodiversity models to assess whether—and how—humanity can reverse the declines in terrestrial biodiversity caused by habitat conversion, which is a major threat to biodiversity5. We show that immediate efforts, consistent with the broader sustainability agenda but of unprecedented ambition and coordination, could enable the provision of food for the growing human population while reversing the global terrestrial biodiversity trends caused by habitat conversion. If we decide to increase the extent of land under conservation management, restore degraded land and generalize landscape-level conservation planning, biodiversity trends from habitat conversion could become positive by the mid-twenty-first century on average across models (confidence interval, 2042–2061), but this was not the case for all models. Food prices could increase and, on average across models, almost half (confidence interval, 34–50%) of the future biodiversity losses could not be avoided. However, additionally tackling the drivers of land-use change could avoid conflict with affordable food provision and reduces the environmental effects of the food-provision system. Through further sustainable intensification and trade, reduced food waste and more plant-based human diets, more than two thirds of future biodiversity losses are avoided and the biodiversity trends from habitat conversion are reversed by 2050 for almost all of the models. Although limiting further loss will remain challenging in several biodiversity-rich regions, and other threats—such as climate change—must be addressed to truly reverse the declines in biodiversity, our results show that ambitious conservation efforts and food system transformation are central to an effective post-2020 biodiversity strategy. To promote the recovery of the currently declining global trends in terrestrial biodiversity, increases in both the extent of land under conservation management and the sustainability of the global food system from farm to fork are required.

We performed a systematic analysis of blood DNA methylation profiles from 4483 participants from seven independent cohorts identifying differentially methylated positions (DMPs) associated with psychosis, schizophrenia, and treatment-resistant schizophrenia. Psychosis cases were characterized by significant differences in measures of blood cell proportions and elevated smoking exposure derived from the DNA methylation data, with the largest differences seen in treatment-resistant schizophrenia patients. We implemented a stringent pipeline to meta-analyze epigenome-wide association study (EWAS) results across datasets, identifying 95 DMPs associated with psychosis and 1048 DMPs associated with schizophrenia, with evidence of colocalization to regions nominated by genetic association studies of disease. Many schizophrenia-associated DNA methylation differences were only present in patients with treatment-resistant schizophrenia, potentially reflecting exposure to the atypical antipsychotic clozapine. Our results highlight how DNA methylation data can be leveraged to identify physiological (e.g., differential cell counts) and environmental (e.g., smoking) factors associated with psychosis and molecular biomarkers of treatment-resistant schizophrenia.

Additional file 5: Supplementary Appendix. Phylogenetic and molecular clock analyses of ASFLI-elements from different tick genomes and ASFV using different clock-rates and substitution models implemented in BEAST. Supplementary Appendix. Figure A1-A5, Tables A1-A7. FigA1- Phylogenetic tree of ASFV and ASFLI-elements. FigA2 – Phylogenetic tree of NCLDV including ASFV and ASFLI-elements. FigA3 – Time-scaled tree for partial EP1242L sequences from tick samples and reference ASFV (non-integrated). FigA4 - Time-scaled tree for partial EP1242L sequences from tick samples only (5e-7 substitutions per site per year). FigA5 - Time-scaled tree for partial EP1242L sequences from tick samples (1e-8 substitutions per site and year). Table A1 - Summary of EP1242L fragments derived from ticks and the tick cell line OME/CTVM21 (OME21) used in the analysis. Table A2 - Indels in the tick sample sequences relative to the start of EP1242L in ASFV|KM111295|Kenya|Ken06/Bus|2006. Table A3 - Estimated root height and overall mean clock rate for strict clocks with fixed priors. Table A4 - Estimated root height and overall (averaged over all branches) mean clock rate for relaxed clocks with fixed priors of the rate of the relaxed clock (some variation). Table A5 - Estimated root height and overall (averaged over all branches) mean clock rate for relaxed clocks with normal or log-normal priors on the rate of the relaxed clock (most variation). Table A6 - Estimated root height and overall (averaged over all branches) mean clock rate for strict clocks with log-normal priors on the rate of the strict clock for the five ASFV-like sequences from tick samples only. Table A7 - Marginal likelihood estimation using Path Sampling and Stepping Stone Sampling, showing that the log-normal clock rate prior with mean = 5e-7 is best, but not significantly better than the other clock rates.

AbstractMetagenomics has made accessible an enormous reserve of global biochemical diversity. To tap into this vast resource of novel enzymes, we have screened over one million clones from metagenome DNA libraries derived from sixteen different environments for carboxylesterase activity and identified 714 positive hits. We have validated the esterase activity of 80 selected genes, which belong to 17 different protein families including unknown and cyclase-like proteins. Three metagenomic enzymes exhibited lipase activity, and seven proteins showed polyester depolymerization activity against polylactic acid and polycaprolactone. Detailed biochemical characterization of four new enzymes revealed their substrate preference, whereas their catalytic residues were identified using site-directed mutagenesis. The crystal structure of the metal-ion dependent esterase MGS0169 from the amidohydrolase superfamily revealed a novel active site with a bound unknown ligand. Thus, activity-centered metagenomics has revealed diverse enzymes and novel families of microbial carboxylesterases, whose activity could not have been predicted using bioinformatics tools.

Abstract The traditional forcing–feedback framework has provided an indispensable basis for discussing global climate changes. However, as analysis of model behavior has become more detailed, shortcomings and ambiguities in the framework have become more evident, and physical effects unaccounted for by the traditional framework have become interesting. In particular, the new concept of adjustments, which are responses to forcings that are not mediated by the global-mean temperature, has emerged. This concept, related to the older ones of climate efficacy and stratospheric adjustment, is a more physical way of capturing unique responses to specific forcings. We present a pedagogical review of the adjustment concept, why it is important, and how it can be used. The concept is particularly useful for aerosols, where it helps to organize what has become a complex array of forcing mechanisms. It also helps clarify issues around cloud and hydrological response, transient versus equilibrium climate change, and geoengineering.

The severe drought of the 1930s Dust Bowl decade coincided with record-breaking summer heatwaves that contributed to the socio-economic and ecological disaster over North America’s Great Plains. It remains unresolved to what extent these exceptional heatwaves, hotter than in historically forced coupled climate model simulations, were forced by sea surface temperatures (SSTs) and exacerbated through human-induced deterioration of land cover. Here we show, using an atmospheric-only model, that anomalously warm North Atlantic SSTs enhance heatwave activity through an association with drier spring conditions resulting from weaker moisture transport. Model devegetation simulations, that represent the wide-spread exposure of bare soil in the 1930s, suggest human activity fueled stronger and more frequent heatwaves through greater evaporative drying in the warmer months. This study highlights the potential for the amplification of naturally occurring extreme events like droughts by vegetation feedbacks to create more extreme heatwaves in a warmer world. In the 1930s, the US was hit by a severe drought and record-breaking heatwaves in a period known as the Dust Bowl. Here, the authors present model experiments that suggest that warm North Atlantic temperatures and human devegetation played key roles in making these heatwaves particularly strong.