- home
- Advanced Search
Filters
Clear All- SDSN - Greece
- Publications
- Archivio Istituzionale della Ricerc...
- Aurora Universities Network
- SDSN - Greece
- Publications
- Archivio Istituzionale della Ricerc...
- Aurora Universities Network
Loading
description Publicationkeyboard_double_arrow_right Article 2020 Denmark, Italy, Netherlands, ItalyPublisher:Elsevier BV Funded by:EC | EuroMixEC| EuroMixCorinne, Sprong; Amélie, Crépet; Francesca, Metruccio; Urska, Blaznik; Chris, Anagnostopoulos; Despo Louca, Christodoulou; Bodil Hamborg, Jensen; Marc, Kennedy; Neus, González; Irena, Rehurkova; Jiří, Ruprich; Jan Dirk, Te Biesebeek; Marie, Vanacker; Angelo, Moretto; Jacob, van Klaveren;Risk assessment of chemicals occurring in our diet is commonly performed for single chemicals without considering exposure to other chemicals. We performed a case study on risk assessment of combined dietary exposure to chemicals from different regulatory silos, i.e. pesticides (PPRs), persistent organic pollutants (POPs) and food additives (FAs). Chemicals were grouped into the cumulative assessment group (CAG) liver steatosis using a component-based approach. Based on literature, the CAG included 144 PPRs, 49 POPS and 7 FAs for which concentration data were available. For each silo, chronic combined dietary exposure was assessed for adults and children of nine European countries following the most commonly used exposure methodologies in Europe and by using a relative potency factor approach. For risk characterization, a Margin of Exposure (MOE) was calculated. To overarch the risk across silos, a normalised combined margin of exposure (nMOET) approach was proposed. This case study demonstrated that risk assessment of combined exposure to chemicals can be performed within regulatory silos. It also highlighted important differences in the conservatism of exposure scenarios, the derivation of point of departures and the subsequent acceptable MOEs between the silos. To overarch the risk despite these differences, a nMOET approach can be used.
Online Research Data... arrow_drop_down Online Research Database In TechnologyArticle . 2020Data sources: Online Research Database In TechnologyArchivio istituzionale della ricerca - Università di Padova; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Food and Chemical ToxicologyArticle . 2020 . Peer-reviewedLicense: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.fct.2020.111416&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 11 citations 11 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Online Research Data... arrow_drop_down Online Research Database In TechnologyArticle . 2020Data sources: Online Research Database In TechnologyArchivio istituzionale della ricerca - Università di Padova; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Food and Chemical ToxicologyArticle . 2020 . Peer-reviewedLicense: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.fct.2020.111416&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Netherlands, France, Italy, DenmarkPublisher:Elsevier BV Funded by:EC | EuroMixEC| EuroMixCrépet, Amélie; Vanacker, Marie; Sprong, Corinne; de Boer, Waldo; Blaznik, Urska; Kennedy, Marc; Anagnostopoulos, Chris; Christodoulou, Despo Louca; Ruprich, Jiří; Rehurkova, Irena; Domingo, José Luis; Hamborg Jensen, Bodil; Metruccio, Francesca; Moretto, Angelo; Jacxsens, Liesbeth; Spanoghe, Pieter; Senaeve, David; van der Voet, Hilko; van Klaveren, Jacob;Populations are exposed to mixtures of pesticides through their diet on a daily basis. The question of which substances should be assessed together remains a major challenge due to the complexity of the mixtures. In addition, the associated risk is difficult to characterise. The EuroMix project (European Test and Risk Assessment Strategies for Mixtures) has developed a strategy for mixture risk assessment. In particular, it has proposed a methodology that combines exposures and hazard information to identify relevant mixtures of chemicals belonging to any cumulative assessment group (CAG) to which the European population is exposed via food. For the purposes of this study, food consumption and pesticide residue data in food and drinking water were obtained from national surveys in nine European countries. Mixtures of pesticides were identified by a sparse non-negative matrix underestimation (SNMU) applied to the specific liver steatosis effect in children from 11 to 15 years of age, and in adults from 18 to 64 years of age in nine European countries. Exposures and mixtures of 144 pesticides were evaluated through four different scenarios: (1) chronic exposure with a merged concentration dataset in the adult population, (2) chronic exposure with country-specific concentration datasets in the adult population, (3) acute exposure with a merged concentration dataset in the adult population, and (4) chronic exposure with a merged concentration dataset in the paediatric population. The relative potency factors of each substance were calculated to express their potency relative to flusilazole, which was chosen as the reference compound. The selection of mixtures and the evaluation of exposures for each country were carried out using the Monte Carlo Risk Assessment (MCRA) software. Concerning chronic exposure, one mixture explained the largest proportion of the total variance for each country, while in acute exposure, several mixtures were often involved. The results showed that there were 15 main pesticides in the mixtures, with a high contribution of imazalil and dithiocarbamate. Since the concentrations provided by the different countries were merged in the scenario u Populations are exposed to mixtures of pesticides through their diet on a daily basis. The question of which substances should be assessed together remains a major challenge due to the complexity of the mixtures. In addition, the associated risk is difficult to characterise. The EuroMix project (European Test and Risk Assessment Strategies for Mixtures) has developed a strategy for mixture risk assessment. In particular, it has proposed a methodology that combines exposures and hazard information to identify relevant mixtures of chemicals belonging to any cumulative assessment group (CAG) to which the European population is exposed via food. For the purposes of this study, food consumption and pesticide residue data in food and drinking water were obtained from national surveys in nine European countries. Mixtures of pesticides were identified by a sparse non-negative matrix underestimation (SNMU) applied to the specific liver steatosis effect in children from 11 to 15 years of age, and in adults from 18 to 64 years of age in nine European countries. Exposures and mixtures of 144 pesticides were evaluated through four different scenarios: (1) chronic exposure with a merged concentration dataset in the adult population, (2) chronic exposure with country-specific concentration datasets in the adult population, (3) acute exposure with a merged concentration dataset in the adult population, and (4) chronic exposure with a merged concentration dataset in the paediatric population. The relative potency factors of each substance were calculated to express their potency relative to flusilazole, which was chosen as the reference compound. The selection of mixtures and the evaluation of exposures for each country were carried out using the Monte Carlo Risk Assessment (MCRA) software. Concerning chronic exposure, one mixture explained the largest proportion of the total variance for each country, while in acute exposure, several mixtures were often involved. The results showed that there were 15 main pesticides in the mixtures, with a high contribution of imazalil and dithiocarbamate. Since the concentrations provided by the different countries were merged in the scenario using merged concentration data, differences between countries result from differences in food consumption behaviours. These results support the approach that using merged concentration data to estimate exposures in Europe seems to be realistic, as foods are traded across European borders. The originality of the proposed approach was to start from a CAG and to integrate information from combined exposures to identify a refined list of mixtures with fewer components. As this approach was sensitive to the input data and required significant resources, efforts should continue regarding data collection and harmonisation among the different aspects within the pesticides regulatory framework, and to develop methods to group substances and mixtures to characterise the risk. sing merged concentration data, differences between countries result from differences in food consumption behaviours. These results support the approach that using merged concentration data to estimate exposures in Europe seems to be realistic, as foods are traded across European borders. The originality of the proposed approach was to start from a CAG and to integrate information from combined exposures to identify a refined list of mixtures with fewer components. As this approach was sensitive to the input data and required significant resources, efforts should continue regarding data collection and harmonisation among the different aspects within the pesticides regulatory framework, and to develop methods to group substances and mixtures to characterise the risk.
Research@WUR; ZENODO... arrow_drop_down Research@WUR; ZENODO; International Journal of Hygiene and Environmental Health; Archivio Istituzionale della Ricerca dell'Università degli Studi di MilanoOther literature type . Article . 2019 . Peer-reviewedLicense: Elsevier TDMInternational Journal of Hygiene and Environmental HealthArticleLicense: CC BY NCData sources: UnpayWallOnline Research Database In TechnologyArticle . 2019Data sources: Online Research Database In TechnologyMémoires en Sciences de l'Information et de la CommunicationArticle . 2019License: CC BY NCFull-Text: https://hal.science/hal-03485673/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ijheh.2018.12.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 33 citations 33 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Research@WUR; ZENODO... arrow_drop_down Research@WUR; ZENODO; International Journal of Hygiene and Environmental Health; Archivio Istituzionale della Ricerca dell'Università degli Studi di MilanoOther literature type . Article . 2019 . Peer-reviewedLicense: Elsevier TDMInternational Journal of Hygiene and Environmental HealthArticleLicense: CC BY NCData sources: UnpayWallOnline Research Database In TechnologyArticle . 2019Data sources: Online Research Database In TechnologyMémoires en Sciences de l'Information et de la CommunicationArticle . 2019License: CC BY NCFull-Text: https://hal.science/hal-03485673/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ijheh.2018.12.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2011 Netherlands, ItalyPublisher:Elsevier BV Funded by:EC | ESCAPE, NIH | Prenatal air pollution, D..., SNSF | SAPALDIA Off-spring studyEC| ESCAPE ,NIH| Prenatal air pollution, DNA methylation and early signs of atherosclerosis ,SNSF| SAPALDIA Off-spring studyKünzli Nino; Perez Laura; von Klot Stephanie; Baldassarre Damiano; Bauer Marcus; Basagana Xavier; Breton Carrie; Dratva Julia; Elosua Roberto; de Faire Ulf; Fuks Kateryna; de Groot Eric; Marrugat Jaume; Penell Johanna; Seissler Jochen; Peters Annette; Hoffmann Barbara;Although ambient particulate matter contributes to atherosclerosis in animal models, its role in atherogenesis in humans needs to be established. This article discusses concepts, study design, and choice of health outcomes to efficiently investigate the atherogenic role of ambient air pollution, with an emphasis on early preclinical biomarkers of atherosclerosis that are unaffected by short-term exposure to air pollution (eg, carotid intima-media thickness [CIMT] and functional performance of the vessel). Air pollution studies using these end points are summarized. The CIMT is currently the most frequently used outcome in this field (6 studies). The continuous nature of CIMT, the lack of short-term variation, its relationship to atherosclerotic changes in the artery wall, its predictive value for coronary heart disease, and the noninvasiveness of the assessment make it a useful candidate for cross-sectional and longitudinal studies investigating the role of air pollution in atherogenesis.
Universitätsbibliogr... arrow_drop_down Universitätsbibliographie, Universität Duisburg-EssenArticle . 2011Data sources: Universitätsbibliographie, Universität Duisburg-EssenProgress in Cardiovascular Diseases; Archivio Istituzionale della Ricerca dell'Università degli Studi di MilanoOther literature type . Article . 2011 . Peer-reviewedLicense: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.pcad.2010.12.006&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu63 citations 63 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Universitätsbibliogr... arrow_drop_down Universitätsbibliographie, Universität Duisburg-EssenArticle . 2011Data sources: Universitätsbibliographie, Universität Duisburg-EssenProgress in Cardiovascular Diseases; Archivio Istituzionale della Ricerca dell'Università degli Studi di MilanoOther literature type . Article . 2011 . Peer-reviewedLicense: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.pcad.2010.12.006&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu
Loading
description Publicationkeyboard_double_arrow_right Article 2020 Denmark, Italy, Netherlands, ItalyPublisher:Elsevier BV Funded by:EC | EuroMixEC| EuroMixCorinne, Sprong; Amélie, Crépet; Francesca, Metruccio; Urska, Blaznik; Chris, Anagnostopoulos; Despo Louca, Christodoulou; Bodil Hamborg, Jensen; Marc, Kennedy; Neus, González; Irena, Rehurkova; Jiří, Ruprich; Jan Dirk, Te Biesebeek; Marie, Vanacker; Angelo, Moretto; Jacob, van Klaveren;Risk assessment of chemicals occurring in our diet is commonly performed for single chemicals without considering exposure to other chemicals. We performed a case study on risk assessment of combined dietary exposure to chemicals from different regulatory silos, i.e. pesticides (PPRs), persistent organic pollutants (POPs) and food additives (FAs). Chemicals were grouped into the cumulative assessment group (CAG) liver steatosis using a component-based approach. Based on literature, the CAG included 144 PPRs, 49 POPS and 7 FAs for which concentration data were available. For each silo, chronic combined dietary exposure was assessed for adults and children of nine European countries following the most commonly used exposure methodologies in Europe and by using a relative potency factor approach. For risk characterization, a Margin of Exposure (MOE) was calculated. To overarch the risk across silos, a normalised combined margin of exposure (nMOET) approach was proposed. This case study demonstrated that risk assessment of combined exposure to chemicals can be performed within regulatory silos. It also highlighted important differences in the conservatism of exposure scenarios, the derivation of point of departures and the subsequent acceptable MOEs between the silos. To overarch the risk despite these differences, a nMOET approach can be used.
Online Research Data... arrow_drop_down Online Research Database In TechnologyArticle . 2020Data sources: Online Research Database In TechnologyArchivio istituzionale della ricerca - Università di Padova; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Food and Chemical ToxicologyArticle . 2020 . Peer-reviewedLicense: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.fct.2020.111416&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 11 citations 11 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Online Research Data... arrow_drop_down Online Research Database In TechnologyArticle . 2020Data sources: Online Research Database In TechnologyArchivio istituzionale della ricerca - Università di Padova; Archivio Istituzionale della Ricerca dell'Università degli Studi di Milano; Food and Chemical ToxicologyArticle . 2020 . Peer-reviewedLicense: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.fct.2020.111416&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Netherlands, France, Italy, DenmarkPublisher:Elsevier BV Funded by:EC | EuroMixEC| EuroMixCrépet, Amélie; Vanacker, Marie; Sprong, Corinne; de Boer, Waldo; Blaznik, Urska; Kennedy, Marc; Anagnostopoulos, Chris; Christodoulou, Despo Louca; Ruprich, Jiří; Rehurkova, Irena; Domingo, José Luis; Hamborg Jensen, Bodil; Metruccio, Francesca; Moretto, Angelo; Jacxsens, Liesbeth; Spanoghe, Pieter; Senaeve, David; van der Voet, Hilko; van Klaveren, Jacob;Populations are exposed to mixtures of pesticides through their diet on a daily basis. The question of which substances should be assessed together remains a major challenge due to the complexity of the mixtures. In addition, the associated risk is difficult to characterise. The EuroMix project (European Test and Risk Assessment Strategies for Mixtures) has developed a strategy for mixture risk assessment. In particular, it has proposed a methodology that combines exposures and hazard information to identify relevant mixtures of chemicals belonging to any cumulative assessment group (CAG) to which the European population is exposed via food. For the purposes of this study, food consumption and pesticide residue data in food and drinking water were obtained from national surveys in nine European countries. Mixtures of pesticides were identified by a sparse non-negative matrix underestimation (SNMU) applied to the specific liver steatosis effect in children from 11 to 15 years of age, and in adults from 18 to 64 years of age in nine European countries. Exposures and mixtures of 144 pesticides were evaluated through four different scenarios: (1) chronic exposure with a merged concentration dataset in the adult population, (2) chronic exposure with country-specific concentration datasets in the adult population, (3) acute exposure with a merged concentration dataset in the adult population, and (4) chronic exposure with a merged concentration dataset in the paediatric population. The relative potency factors of each substance were calculated to express their potency relative to flusilazole, which was chosen as the reference compound. The selection of mixtures and the evaluation of exposures for each country were carried out using the Monte Carlo Risk Assessment (MCRA) software. Concerning chronic exposure, one mixture explained the largest proportion of the total variance for each country, while in acute exposure, several mixtures were often involved. The results showed that there were 15 main pesticides in the mixtures, with a high contribution of imazalil and dithiocarbamate. Since the concentrations provided by the different countries were merged in the scenario u Populations are exposed to mixtures of pesticides through their diet on a daily basis. The question of which substances should be assessed together remains a major challenge due to the complexity of the mixtures. In addition, the associated risk is difficult to characterise. The EuroMix project (European Test and Risk Assessment Strategies for Mixtures) has developed a strategy for mixture risk assessment. In particular, it has proposed a methodology that combines exposures and hazard information to identify relevant mixtures of chemicals belonging to any cumulative assessment group (CAG) to which the European population is exposed via food. For the purposes of this study, food consumption and pesticide residue data in food and drinking water were obtained from national surveys in nine European countries. Mixtures of pesticides were identified by a sparse non-negative matrix underestimation (SNMU) applied to the specific liver steatosis effect in children from 11 to 15 years of age, and in adults from 18 to 64 years of age in nine European countries. Exposures and mixtures of 144 pesticides were evaluated through four different scenarios: (1) chronic exposure with a merged concentration dataset in the adult population, (2) chronic exposure with country-specific concentration datasets in the adult population, (3) acute exposure with a merged concentration dataset in the adult population, and (4) chronic exposure with a merged concentration dataset in the paediatric population. The relative potency factors of each substance were calculated to express their potency relative to flusilazole, which was chosen as the reference compound. The selection of mixtures and the evaluation of exposures for each country were carried out using the Monte Carlo Risk Assessment (MCRA) software. Concerning chronic exposure, one mixture explained the largest proportion of the total variance for each country, while in acute exposure, several mixtures were often involved. The results showed that there were 15 main pesticides in the mixtures, with a high contribution of imazalil and dithiocarbamate. Since the concentrations provided by the different countries were merged in the scenario using merged concentration data, differences between countries result from differences in food consumption behaviours. These results support the approach that using merged concentration data to estimate exposures in Europe seems to be realistic, as foods are traded across European borders. The originality of the proposed approach was to start from a CAG and to integrate information from combined exposures to identify a refined list of mixtures with fewer components. As this approach was sensitive to the input data and required significant resources, efforts should continue regarding data collection and harmonisation among the different aspects within the pesticides regulatory framework, and to develop methods to group substances and mixtures to characterise the risk. sing merged concentration data, differences between countries result from differences in food consumption behaviours. These results support the approach that using merged concentration data to estimate exposures in Europe seems to be realistic, as foods are traded across European borders. The originality of the proposed approach was to start from a CAG and to integrate information from combined exposures to identify a refined list of mixtures with fewer components. As this approach was sensitive to the input data and required significant resources, efforts should continue regarding data collection and harmonisation among the different aspects within the pesticides regulatory framework, and to develop methods to group substances and mixtures to characterise the risk.
Research@WUR; ZENODO... arrow_drop_down Research@WUR; ZENODO; International Journal of Hygiene and Environmental Health; Archivio Istituzionale della Ricerca dell'Università degli Studi di MilanoOther literature type . Article . 2019 . Peer-reviewedLicense: Elsevier TDMInternational Journal of Hygiene and Environmental HealthArticleLicense: CC BY NCData sources: UnpayWallOnline Research Database In TechnologyArticle . 2019Data sources: Online Research Database In TechnologyMémoires en Sciences de l'Information et de la CommunicationArticle . 2019License: CC BY NCFull-Text: https://hal.science/hal-03485673/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ijheh.2018.12.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 33 citations 33 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Research@WUR; ZENODO... arrow_drop_down Research@WUR; ZENODO; International Journal of Hygiene and Environmental Health; Archivio Istituzionale della Ricerca dell'Università degli Studi di MilanoOther literature type . Article . 2019 . Peer-reviewedLicense: Elsevier TDMInternational Journal of Hygiene and Environmental HealthArticleLicense: CC BY NCData sources: UnpayWallOnline Research Database In TechnologyArticle . 2019Data sources: Online Research Database In TechnologyMémoires en Sciences de l'Information et de la CommunicationArticle . 2019License: CC BY NCFull-Text: https://hal.science/hal-03485673/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ijheh.2018.12.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2011 Netherlands, ItalyPublisher:Elsevier BV Funded by:EC | ESCAPE, NIH | Prenatal air pollution, D..., SNSF | SAPALDIA Off-spring studyEC| ESCAPE ,NIH| Prenatal air pollution, DNA methylation and early signs of atherosclerosis ,SNSF| SAPALDIA Off-spring studyKünzli Nino; Perez Laura; von Klot Stephanie; Baldassarre Damiano; Bauer Marcus; Basagana Xavier; Breton Carrie; Dratva Julia; Elosua Roberto; de Faire Ulf; Fuks Kateryna; de Groot Eric; Marrugat Jaume; Penell Johanna; Seissler Jochen; Peters Annette; Hoffmann Barbara;Although ambient particulate matter contributes to atherosclerosis in animal models, its role in atherogenesis in humans needs to be established. This article discusses concepts, study design, and choice of health outcomes to efficiently investigate the atherogenic role of ambient air pollution, with an emphasis on early preclinical biomarkers of atherosclerosis that are unaffected by short-term exposure to air pollution (eg, carotid intima-media thickness [CIMT] and functional performance of the vessel). Air pollution studies using these end points are summarized. The CIMT is currently the most frequently used outcome in this field (6 studies). The continuous nature of CIMT, the lack of short-term variation, its relationship to atherosclerotic changes in the artery wall, its predictive value for coronary heart disease, and the noninvasiveness of the assessment make it a useful candidate for cross-sectional and longitudinal studies investigating the role of air pollution in atherogenesis.
Universitätsbibliogr... arrow_drop_down Universitätsbibliographie, Universität Duisburg-EssenArticle . 2011Data sources: Universitätsbibliographie, Universität Duisburg-EssenProgress in Cardiovascular Diseases; Archivio Istituzionale della Ricerca dell'Università degli Studi di MilanoOther literature type . Article . 2011 . Peer-reviewedLicense: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.pcad.2010.12.006&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu63 citations 63 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Universitätsbibliogr... arrow_drop_down Universitätsbibliographie, Universität Duisburg-EssenArticle . 2011Data sources: Universitätsbibliographie, Universität Duisburg-EssenProgress in Cardiovascular Diseases; Archivio Istituzionale della Ricerca dell'Università degli Studi di MilanoOther literature type . Article . 2011 . Peer-reviewedLicense: Elsevier TDMadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.pcad.2010.12.006&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu