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description Publicationkeyboard_double_arrow_right Article 2023 DenmarkPublisher:Springer Science and Business Media LLC Funded by:EC | ERA4CS, NWO | Translating climate servi...EC| ERA4CS ,NWO| Translating climate service into personalized adaptation strategies to cope with thermal climate stress (ClimApp)Jakob Eggeling; Christofer Rydenfält; Amitava Halder; Jørn Toftum; Lars Nybo; Boris Kingma; Chuansi Gao;AbstractThe ClimApp smartphone application was developed to merge meteorological forecast data with personal information for individualized and improved thermal warning during heat and cold stress and for indoor comfort in buildings. For cold environments, ClimApp predicts the personal thermal stress and strain by the use of the Insulation REQuired model that combines weather and personal physiological data with additional consideration of the Wind Chill index based on the local weather forecast. In this study, we validated the individualized ClimApp index relative to measurements and compared it with the Universal Temperature Climate Index (UTCI). To this aim, 55 participants (27 females) were exposed to at least 1 h in an outdoor environment of 10 °C or below (average 1.4 °C air temperature, 74.9% relative humidity, and 4.7 m/s air velocity) inputting their activity level and clothing insulation as instructed by ClimApp. The UTCI and ClimApp indices were calculated and compared to the participants’ perceived thermal sensation. The ClimApp index root mean square deviation (RMSD) was below the standard deviation of the perceived thermal sensation which indicates a valid prediction and the UTCI RMSD was higher than the standard deviation which indicates an invalid prediction. The correlation of ClimApp and UTCI to the perceived thermal sensation was statistically significant for both models.
Copenhagen Universit... arrow_drop_down Copenhagen University Research Information SystemArticle . 2023Data sources: Copenhagen University Research Information SystemOnline Research Database In TechnologyArticle . 2023Data sources: Online Research Database In TechnologyInternational Journal of BiometeorologyArticle . 2023 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routeshybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Copenhagen Universit... arrow_drop_down Copenhagen University Research Information SystemArticle . 2023Data sources: Copenhagen University Research Information SystemOnline Research Database In TechnologyArticle . 2023Data sources: Online Research Database In TechnologyInternational Journal of BiometeorologyArticle . 2023 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Preprint 2023 France, Denmark, United Kingdom, SwitzerlandPublisher:Copernicus GmbH Funded by:NSF | Biomass Burning, Dust, Se..., NSF | Collaborative Research: C..., EC | ICE&LASERS +4 projectsNSF| Biomass Burning, Dust, Sea Salt, Volcanic & Pollution Aerosols in the Arctic during the Last 2 Millennia: High Resolution Aerosol Records from NEEM & an Aray of Archived Ice Cores ,NSF| Collaborative Research: Continuous Records of Greenhouse Gases and Aerosol Deposition During the Holocene: Testing the Fidelity of New Methods for Reconstructing Atmospheric Change ,EC| ICE&LASERS ,EC| PEGASOS ,NSF| Development of High-Resolution, Multi-Century Records of Trace Element Deposition in West-Central Greenland Using ICP-MS ,NSF| Collaborative Research: Reconstruction of Carbon Monoxide in the Pre-Industrial Arctic Atmosphere from Ice Cores at Summit, Greenland ,NSF| PIRE: International Collaboration and Education in Ice Core Science (ICE-ICS)X. Faïn; D. M. Etheridge; D. M. Etheridge; K. Fourteau; P. Martinerie; C. M. Trudinger; C. M. Trudinger; R. H. Rhodes; N. J. Chellman; R. L. Langenfelds; J. R. McConnell; M. A. J. Curran; M. A. J. Curran; E. J. Brook; T. Blunier; G. Teste; R. Grilli; A. Lemoine; W. T. Sturges; B. Vannière; B. Vannière; J. Freitag; J. Chappellaz; J. Chappellaz;Abstract. Carbon monoxide (CO) is a naturally occurring atmospheric trace gas, a regulated pollutant, and one of the main components determining the oxidative capacity of the atmosphere. Evaluating climate–chemistry models under different conditions than today and constraining past CO sources requires a reliable record of atmospheric CO mixing ratios ([CO]) that includes data since preindustrial times. Here, we report the first continuous record of atmospheric [CO] for Southern Hemisphere (SH) high latitudes over the past 3 millennia. Our continuous record is a composite of three high-resolution Antarctic ice core gas records and firn air measurements from seven Antarctic locations. The ice core gas [CO] records were measured by continuous flow analysis (CFA), using an optical feedback cavity-enhanced absorption spectrometer (OF-CEAS), achieving excellent external precision (2.8–8.8 ppb; 2σ) and consistently low blanks (ranging from 4.1±1.2 to 7.4±1.4 ppb), thus enabling paleo-atmospheric interpretations. Six new firn air [CO] Antarctic datasets collected between 1993 and 2016 CE at the DE08-2, DSSW19K, DSSW20K, South Pole, Aurora Basin North (ABN), and Lock-In sites (and one previously published firn CO dataset at Berkner) were used to reconstruct the atmospheric history of CO from ∼1897 CE, using inverse modeling that incorporates the influence of gas transport in firn. Excellent consistency was observed between the youngest ice core gas [CO] and the [CO] from the base of the firn and between the recent firn [CO] and atmospheric [CO] measurements at Mawson station (eastern Antarctica), yielding a consistent and contiguous record of CO across these different archives. Our Antarctic [CO] record is relatively stable from −835 to 1500 CE, with mixing ratios within a 30–45 ppb range (2σ). There is a ∼5 ppb decrease in [CO] to a minimum at around 1700 CE during the Little Ice Age. CO mixing ratios then increase over time to reach a maximum of ∼54 ppb by ∼1985 CE. Most of the industrial period [CO] growth occurred between about 1940 to 1985 CE, after which there was an overall [CO] decrease, as observed in Greenland firn air and later at atmospheric monitoring sites and attributed partly to reduced CO emissions from combustion sources. Our Antarctic ice core gas CO observations differ from previously published records in two key aspects. First, our mixing ratios are significantly lower than reported previously, suggesting that previous studies underestimated blank contributions. Second, our new CO record does not show a maximum in the late 1800s. The absence of a [CO] peak around the turn of the century argues against there being a peak in Southern Hemisphere biomass burning at this time, which is in agreement with (i) other paleofire proxies such as ethane or acetylene and (ii) conclusions reached by paleofire modeling. The combined ice core and firn air [CO] history, spanning −835 to 1992 CE, extended to the present by the Mawson atmospheric record, provides a useful benchmark for future atmospheric chemistry modeling studies. International audience
Mémoires en Sciences... arrow_drop_down Copernicus Publications; Climate of the Past (CP)Other literature type . 2023Data sources: Copernicus Publicationshttps://doi.org/10.5194/cp-202...Preprint . 2023 . Peer-reviewedLicense: CC BYData sources: CrossrefInfoscience - EPFL scientific publicationsArticleData sources: Infoscience - EPFL scientific publicationsCopenhagen University Research Information SystemArticle . 2023Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Mémoires en Sciences... arrow_drop_down Copernicus Publications; Climate of the Past (CP)Other literature type . 2023Data sources: Copernicus Publicationshttps://doi.org/10.5194/cp-202...Preprint . 2023 . Peer-reviewedLicense: CC BYData sources: CrossrefInfoscience - EPFL scientific publicationsArticleData sources: Infoscience - EPFL scientific publicationsCopenhagen University Research Information SystemArticle . 2023Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Spain, DenmarkPublisher:Frontiers Media SA Funded by:EC | NOMORFILMEC| NOMORFILMAuthors: Nikoline Jensen; Henrik Elvang Jensen; Bent Aalbaek; Sophie Amalie Blirup-Plum; +19 AuthorsNikoline Jensen; Henrik Elvang Jensen; Bent Aalbaek; Sophie Amalie Blirup-Plum; Sara M. Soto; Sara M. Soto; Virginio Cepas; Yuly López; Yaiza Gabasa; Ignacio Gutiérrez-del-Río; Ignacio Gutiérrez-del-Río; Ignacio Gutiérrez-del-Río; Claudio J. Villar; Claudio J. Villar; Claudio J. Villar; Felipe Lombó; Felipe Lombó; Felipe Lombó; María José Iglesias; María José Iglesias; Raquel Soengas; Fernando López Ortiz; Louise Kruse Jensen;handle: 10651/67544
Chlorosphaerolactylate B, a newly discovered antimicrobial halometabolite from the cyanobacterium Sphaerospermopsis sp. LEGE 00249 has been synthesized in three steps by using 12-bromododecanoic acid as starting material. A total of 0.5 g was produced for in vitro and in vivo antimicrobial efficacy testing. In vitro, the minimal inhibitory concentration (MIC) was estimated to be 256 mg/L for Staphylococcus aureus, while the minimal biofilm inhibitory concentration (MBIC) was estimated to be 74 mg/L. The in vivo study utilized a porcine model of implant-associated osteomyelitis. In total, 12 female pigs were allocated into 3 groups based on inoculum (n = 4 in each group). An implant cavity (IC) was drilled in the right tibia and followed by inoculation and insertion of a steel implant. All pigs were inoculated with 10 μL containing either: 11.79 mg synthetic Chlorosphaerolactylate B + 104 CFU of S. aureus (Group A), 104 CFU of S. aureus (Group B), or pure saline (Group C), respectively. Pigs were euthanized five days after inoculation. All Group B animals showed macroscopic and microscopic signs of bone infection and both tissue and implant harbored S. aureus bacteria (mean CFU on implants = 1.9 × 105). In contrast, S. aureus could not be isolated from animals inoculated with saline. In Group A, two animals had a low number of S. aureus (CFU = 6.7 × 101 and 3.8 × 101, respectively) on the implants, otherwise all Group A animals were similar to Group C animals. In conclusion, synthetic Chlorosphaerolactylate B holds potential to be a novel antimicrobial and antibiofilm compound.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 Denmark, France, Austria, Italy, Germany, Russian Federation, Netherlands, France, Italy, Germany, Denmark, Brazil, Australia, Spain, Italy, Italy, Italy, FrancePublisher:Springer Science and Business Media LLC Funded by:EC | VERIFY, NSERC, NSF | Doctoral Dissertation Res... +11 projectsEC| VERIFY ,NSERC ,NSF| Doctoral Dissertation Research: Effects of a Dispersal Barrier on Cultural Similarity in Wild Orangutans (Pongo pygmaeus wurmbii) ,EC| CARE4C ,EC| T-FORCES ,UKRI| Amazon Integrated Carbon Analysis / AMAZONICA ,UKRI| Tropical Biomes in Transition ,EC| FUNDIVEUROPE ,NSF| BII-Implementation: The causes and consequences of plant biodiversity across scales in a rapidly changing world ,UKRI| RootDetect: Remote Detection and Precision Management of Root Health ,EC| OEMC ,EC| RESONATE ,UKRI| Tropical forests responses to a changing climate: a quest at the interface between trait-based ecology, forest dynamics and remote sensing ,NSF| CIF21 DIBBs: EI: Creating a Digital Environment for Enabling Data-Driven Science (DEEDS)Jingjing Liang; Javier G. P. Gamarra; Nicolas Picard; Mo Zhou; Bryan Pijanowski; Douglass F. Jacobs; Peter B. Reich; Thomas W. Crowther; Gert-Jan Nabuurs; Sergio de-Miguel; Jingyun Fang; Christopher W. Woodall; Jens-Christian Svenning; Tommaso Jucker; Jean-Francois Bastin; Susan K. Wiser; Ferry Slik; Bruno Hérault; Giorgio Alberti; Gunnar Keppel; Geerten M. Hengeveld; Pierre L. Ibisch; Carlos A. Silva; Hans ter Steege; Pablo L. Peri; David A. Coomes; Eric B. Searle; Klaus von Gadow; Bogdan Jaroszewicz; Akane O. Abbasi; Meinrad Abegg; Yves C. Adou Yao; Jesús Aguirre-Gutiérrez; Angelica M. Almeyda Zambrano; Jan Altman; Esteban Alvarez-Dávila; Juan Gabriel Álvarez-González; Luciana F. Alves; Bienvenu H. K. Amani; Christian A. Amani; Christian Ammer; Bhely Angoboy Ilondea; Clara Antón-Fernández; Valerio Avitabile; Gerardo A. Aymard; Akomian F. Azihou; Johan A. Baard; Timothy R. Baker; Radomir Balazy; Meredith L. Bastian; Rodrigue Batumike; Marijn Bauters; Hans Beeckman; Nithanel Mikael Hendrik Benu; Robert Bitariho; Pascal Boeckx; Jan Bogaert; Frans Bongers; Olivier Bouriaud; Pedro H. S. Brancalion; Susanne Brandl; Francis Q. Brearley; Jaime Briseno-Reyes; Eben N. Broadbent; Helge Bruelheide; Erwin Bulte; Ann Christine Catlin; Roberto Cazzolla Gatti; Ricardo G. César; Han Y. H. Chen; Chelsea Chisholm; Emil Cienciala; Gabriel D. Colletta; José Javier Corral-Rivas; Anibal Cuchietti; Aida Cuni-Sanchez; Javid A. Dar; Selvadurai Dayanandan; Thales de Haulleville; Mathieu Decuyper; Sylvain Delabye; Géraldine Derroire; Ben DeVries; John Diisi; Tran Van Do; Jiri Dolezal; Aurélie Dourdain; Graham P. Durrheim; Nestor Laurier Engone Obiang; Corneille E. N. Ewango; Teresa J. Eyre; Tom M. Fayle; Lethicia Flavine N. Feunang; Leena Finér; Markus Fischer; Jonas Fridman; Lorenzo Frizzera; André L. de Gasper; Damiano Gianelle; Henry B. Glick; Maria Socorro Gonzalez-Elizondo; Lev Gorenstein; Richard Habonayo; Olivier J. Hardy; David J. Harris; Andrew Hector; Andreas Hemp; Martin Herold; Annika Hillers; Wannes Hubau; Thomas Ibanez; Nobuo Imai; Gerard Imani; Andrzej M. Jagodzinski; Stepan Janecek; Vivian Kvist Johannsen; Carlos A. Joly; Blaise Jumbam; Banoho L. P. R. Kabelong; Goytom Abraha Kahsay; Viktor Karminov; Kuswata Kartawinata; Justin N. Kassi; Elizabeth Kearsley; Deborah K. Kennard; Sebastian Kepfer-Rojas; Mohammed Latif Khan; John N. Kigomo; Hyun Seok Kim; Carine Klauberg; Yannick Klomberg; Henn Korjus; Subashree Kothandaraman; Florian Kraxner; Amit Kumar; Relawan Kuswandi; Mait Lang; Michael J. Lawes; Rodrigo V. Leite; Geoffrey Lentner; Simon L. Lewis; Moses B. Libalah; Janvier Lisingo; Pablito Marcelo López-Serrano; Huicui Lu; Natalia V. Lukina; Anne Mette Lykke; Vincent Maicher; Brian S. Maitner; Eric Marcon; Andrew R. Marshall; Emanuel H. Martin; Olga Martynenko; Faustin M. Mbayu; Musingo T. E. Mbuvi; Jorge A. Meave; Cory Merow; Stanislaw Miscicki; Vanessa S. Moreno; Albert Morera; Sharif A. Mukul; Jörg C. Müller; Agustinus Murdjoko; Maria Guadalupe Nava-Miranda; Litonga Elias Ndive; Victor J. Neldner; Radovan V. Nevenic; Louis N. Nforbelie; Michael L. Ngoh; Anny E. N’Guessan; Michael R. Ngugi; Alain S. K. Ngute; Emile Narcisse N. Njila; Melanie C. Nyako; Thomas O. Ochuodho; Jacek Oleksyn; Alain Paquette; Elena I. Parfenova; Minjee Park; Marc Parren; Narayanaswamy Parthasarathy; Sebastian Pfautsch; Oliver L. Phillips; Maria T. F. Piedade; Daniel Piotto; Martina Pollastrini; Lourens Poorter; John R. Poulsen; Axel Dalberg Poulsen; Hans Pretzsch; Mirco Rodeghiero; Samir G. Rolim; Francesco Rovero; Ervan Rutishauser; Khosro Sagheb-Talebi; Purabi Saikia; Moses Nsanyi Sainge; Christian Salas-Eljatib; Antonello Salis; Peter Schall; Dmitry Schepaschenko; Michael Scherer-Lorenzen; Bernhard Schmid; Vladimír Šebeň; Giacomo Sellan; Federico Selvi; Josep M. Serra-Diaz; Douglas Sheil; Plinio Sist; Martin J. P. Sullivan; Miroslav Svoboda; Nadja Tchebakova; Robert Tropek; Peter Mbanda Umunay; Riccardo Valentini; Fons van der Plas; Hans Verbeeck; Alexander C. Vibrans; Jason Vleminckx; Catherine E. Waite; Chemuku Wekesa; Irie C. Zo-Bi; Cang Hui;pmid: 35941205
handle: 10459.1/84893 , 11585/915920 , 11390/1232984 , 10449/76215 , 2158/1279260 , 11541.2/30364 , 11572/351981
pmid: 35941205
handle: 10459.1/84893 , 11585/915920 , 11390/1232984 , 10449/76215 , 2158/1279260 , 11541.2/30364 , 11572/351981
The latitudinal diversity gradient (LDG) is one of the most recognized global patterns of species richness exhibited across a wide range of taxa. Numerous hypotheses have been proposed in the past two centuries to explain LDG, but rigorous tests of the drivers of LDGs have been limited by a lack of high-quality global species richness data. Here we produce a high-resolution (0.025° × 0.025°) map of local tree species richness using a global forest inventory database with individual tree information and local biophysical characteristics from ~1.3 million sample plots. We then quantify drivers of local tree species richness patterns across latitudes. Generally, annual mean temperature was a dominant predictor of tree species richness, which is most consistent with the metabolic theory of biodiversity (MTB). However, MTB underestimated LDG in the tropics, where high species richness was also moderated by topographic, soil and anthropogenic factors operating at local scales. Given that local landscape variables operate synergistically with bioclimatic factors in shaping the global LDG pattern, we suggest that MTB be extended to account for co-limitation by subordinate drivers. United States Department of Agriculture | Agricultural Research Service https://doi.org/10.13039/100007917 National Aeronautics and Space Administration https://doi.org/10.13039/100000104
Mémoires en Sciences... arrow_drop_down Nature Ecology & Evolution; Archivio istituzionale della ricerca - Fondazione Edmund Mach; Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) - Universidade de São Paulo (USP); PURE Aarhus University; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of TrentoArticle . 2022 . Peer-reviewedLicense: Springer TDMData sources: Archivio istituzionale della ricerca - Fondazione Edmund Mach; Crossref; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; NARCIS; PURE Aarhus University; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of TrentoArchiMer - Institutional Archive of IfremerOther literature type . 2022Data sources: ArchiMer - Institutional Archive of IfremerPublikationenserver der Georg-August-Universität GöttingenArticle . 2022GFZ German Research Centre for GeosciencesArticle . 2022Data sources: GFZ German Research Centre for GeosciencesArchiMer - Institutional Archive of IfremerOther literature type . 2022Data sources: ArchiMer - Institutional Archive of IfremerCopenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information SystemUniSA Research Outputs RepositoryArticle . 2022 . Peer-reviewedData sources: UniSA Research Outputs Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 24 citations 24 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Mémoires en Sciences... arrow_drop_down Nature Ecology & Evolution; Archivio istituzionale della ricerca - Fondazione Edmund Mach; Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) - Universidade de São Paulo (USP); PURE Aarhus University; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of TrentoArticle . 2022 . Peer-reviewedLicense: Springer TDMData sources: Archivio istituzionale della ricerca - Fondazione Edmund Mach; Crossref; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; NARCIS; PURE Aarhus University; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of TrentoArchiMer - Institutional Archive of IfremerOther literature type . 2022Data sources: ArchiMer - Institutional Archive of IfremerPublikationenserver der Georg-August-Universität GöttingenArticle . 2022GFZ German Research Centre for GeosciencesArticle . 2022Data sources: GFZ German Research Centre for GeosciencesArchiMer - Institutional Archive of IfremerOther literature type . 2022Data sources: ArchiMer - Institutional Archive of IfremerCopenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information SystemUniSA Research Outputs RepositoryArticle . 2022 . Peer-reviewedData sources: UniSA Research Outputs Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Spain, DenmarkPublisher:Elsevier BV Funded by:EC | NOMORFILMEC| NOMORFILMAuthors: Louise Kruse Jensen; Henrik Elvang Jensen; Sophie Amalie Blirup-Plum; Mats Bue; +17 AuthorsLouise Kruse Jensen; Henrik Elvang Jensen; Sophie Amalie Blirup-Plum; Mats Bue; Pelle Hanberg; Lasse Kvich; Bent Aalbæk; Yuly López; Sara M. Soto; Marilina Douloudi; Michaela Papageorgiou; Eleni Nikoli; Michael Arkas; Ignacio Gutiérrez-del-Río; Sara López-Ibáñez; Claudio J. Villar; Felipe Lombó; Paraskevi Gkomoza; Ioanna Kitsou; Athina Tsetsekou; Michalis Vardavoulias;handle: 10651/66772
The use of bone implants and prostheses has contributed to a revolution in modern medicine; however, in the beginning, not much was asked from the implant and prosthetic materials per se. Therefore, the next game-changer in orthopedic research will come from new material designs which for instance can aid in prevention of implant-associated bone infections. Here, we describe the development of a new sol-gel coating technique that can deliver an efficient antimicrobial surface coating on orthopedic implants. Gentamicin was stocked in a novel nanocomposite xerogel made from silica and hyperbranched polyethyleneimine. The xerogel was anchored inside a porous surface made by coating of bone implants with titanium microspheres. Thereby, only the small water-soluble gentamicin molecules diffused in an aqueous environment, i.e., just after surgical insertion and leaving behind a titanium scaffold for osseointegration. The novel xerogel coating prevented development of severe Staphylococcus aureus induced osteomyelitis in a porcine model, which untreated, replicated the pathology seen in stage 3A on the Cierny–Mader classification system for osteomyelitis in adults.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.mtla.2022.101473&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Italy, DenmarkPublisher:Wiley Funded by:EC | COMPARE, NHMRC | Systems-based study, inte...EC| COMPARE ,NHMRC| Systems-based study, intervention, diagnosis and control of gastrointestinal parasitesGiulia I. Corsi; Swapnil Tichkule; Anna Rosa Sannella; Paolo Vatta; Francesco Asnicar; Nicola Segata; Aaron R. Jex; Cock van Oosterhout; Simone M. Cacciò;AbstractCryptosporidium parvum is a globally distributed zoonotic pathogen and a major cause of diarrhoeal disease in humans and ruminants. The parasite's life cycle comprises an obligatory sexual phase, during which genetic exchanges can occur between previously isolated lineages. Here, we compare 32 whole genome sequences from human‐ and ruminant‐derived parasite isolates collected across Europe, Egypt and China. We identify three strongly supported clusters that comprise a mix of isolates from different host species, geographic origins, and subtypes. We show that: (1) recombination occurs between ruminant isolates into human isolates; (2) these recombinant regions can be passed on to other human subtypes through gene flow and population admixture; (3) there have been multiple genetic exchanges, and most are probably recent; (4) putative virulence genes are significantly enriched within these genetic exchanges, and (5) this results in an increase in their nucleotide diversity. We carefully dissect the phylogenetic sequence of two genetic exchanges, illustrating the long‐term evolutionary consequences of these events. Our results suggest that increased globalization and close human‐animal contacts increase the opportunity for genetic exchanges between previously isolated parasite lineages, resulting in spillover and spillback events. We discuss how this can provide a novel substrate for natural selection at genes involved in host–parasite interactions, thereby potentially altering the dynamic coevolutionary equilibrium in the Red Queens arms race.
Molecular Ecology; I... arrow_drop_down Molecular Ecology; IRIS - Institutional Research Information System of the University of TrentoArticle . 2022 . Peer-reviewedLicense: CC BY NC NDCopenhagen University Research Information SystemArticle . 2023Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/mec.16556&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Molecular Ecology; I... arrow_drop_down Molecular Ecology; IRIS - Institutional Research Information System of the University of TrentoArticle . 2022 . Peer-reviewedLicense: CC BY NC NDCopenhagen University Research Information SystemArticle . 2023Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/mec.16556&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Denmark, SwedenPublisher:Elsevier BV Funded by:EC | DIVERSifyEC| DIVERSifyJames Ajal; Lars P. Kiær; Robin J. Pakeman; Christoph Scherber; Martin Weih;The relevance of intercropping, where two or more crop species are simultaneously grown on the same land space, is growing due to its potential for improving resource use and maintaining stable yields under variable weather conditions. However, the actual growth of intercropped species may differ resulting from the idiosyncratic effect of crop diversity, and with this, the realized benefits from intercrops are found to depend critically on the cultivar, species, management and environmental conditions. This study aimed to apply a trait-based approach, in which ecological niche spaces are defined through n-dimensional hypervolumes, to identify the contribution of species/cultivar, cultivation design (sole crop or intercrop) and management (low or high fertilization) to the trait diversity of four crop species, pea-barley and faba bean-wheat, when grown as sole crops and intercrops. Four traits were used as trait axes for the trait space analysis: canopy height, shoot biomass, tiller/node number, and grain yield. We found that trait spaces differed with crop species and cultivars, and whether they were grown as intercrops or sole crops. Trait spaces differed between high and low fertilization only for the cereals grown in the more productive site (i.e. Denmark). Species grown as intercrops had larger volumes than when grown as sole crops, as a result of trait plasticity. This response to intercropping was apparent in almost all the species grown in Sweden and Denmark, except for wheat in Denmark. The study demonstrated that individual species responded to intercropping compared to sole cropping through the plasticity of traits, which influenced the shape of the hypervolumes to divide up the trait space between the species. The findings are important in illustrating the plastic responses of arable crops, which are relevant for understanding the productivity of species grown in intercrops as compared to sole crops.
Epsilon Open Archive arrow_drop_down Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.baae.2022.03.009&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Epsilon Open Archive arrow_drop_down Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.baae.2022.03.009&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Denmark, NorwayPublisher:Springer Science and Business Media LLC Funded by:EC | ParaFishControlEC| ParaFishControlAina-Cathrine, Øvergård; Helena M D, Midtbø; Lars A, Hamre; Michael, Dondrup; Gro E K, Bjerga; Øivind, Larsen; Jiwan Kumar, Chettri; Kurt, Buchmann; Frank, Nilsen; Sindre, Grotmol;AbstractLittle is known about glandular proteins secreted from the skin- and blood-feeding ectoparasite salmon louse (Lepeophtheirus salmonis). The labial gland has ducts extending into the oral cavity of the lice, and the present study aimed to identify novel genes expressed by this gland type and to investigate their role in modulation of host parameters at the lice feeding site. Five genes associated with labial gland function were identified and named Lepeophteirus salmonis labial gland protein (LsLGP) 1–4 and 1 like (LsLGP1L). All LsLGPs were predicted to be small charged secreted proteins not encoding any known protein domains. Functional studies revealed that LsLGP1 and/or LsLGP1L regulated the expression of other labial gland genes. Immune dampening functions were indicated for LsLGP2 and 3. Whereas LsLGP2 was expressed throughout the parasitic life cycle and found to dampen inflammatory cytokines, LsLGP3 displayed an increased expression in mobile stages and appeared to dampen adaptive immune responses. Expression of LsLGP4 coincided with moulting to the mobile pre-adult I stage where hematophagous feeding is initiated, and synthetic LsLGP4 decreased the clotting time of Atlantic salmon plasma. Results from the present study confirm that the salmon louse secretes immune modulating and anti-coagulative proteins with a potential application in new immune based anti-salmon louse treatments.
Scientific Reports arrow_drop_down Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information SystemBergen Open Research Archive - UiB; Norwegian Open Research ArchivesArticle . 2022 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41598-022-11773-w&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Scientific Reports arrow_drop_down Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information SystemBergen Open Research Archive - UiB; Norwegian Open Research ArchivesArticle . 2022 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41598-022-11773-w&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Denmark, France, France, Germany, France, SpainPublisher:eLife Sciences Publications, Ltd Funded by:EC | INMAREEC| INMAREChiara Vanni; Matthew S Schechter; Silvia G Acinas; Albert Barberán; Pier Luigi Buttigieg; Emilio O Casamayor; Tom O Delmont; Carlos M Duarte; A Murat Eren; Robert D Finn; Renzo Kottmann; Alex Mitchell; Pablo Sánchez; Kimmo Siren; Martin Steinegger; Frank Oliver Gloeckner; Antonio Fernàndez-Guerra;The authors thankfully acknowledge the computer resources at MareNostrum and the technical support provided by Barcelona Supercomputing Center (RES-AECT-2014-2-0085), the BMBF877 funded de.NBI Cloud within the German Network for Bioinformatics Infrastructure (de.NBI) (031A537B, 031A533A, 031A538A, 031A533B, 031A535A, 031A537C, 031A534A, 031A532B), the University of Oxford Advanced Research Computing (http://dx.doi.org/10.5281/zenodo.22558) and the MARBITS bioinformatics core at ICM-CSIC.CV was supported by the Max Planck Society. AFG received funding from the European Union’s Horizon 2020 research and innovation program Blue Growth: Unlocking the potential of Seas and Oceans under grant agreement no. 634486 (project acronym INMARE). AM was supported by the Biotechnology and Biological Sciences Research Council [BB/M011755/1, BB/R015228/1] and RDF by the European Molecular Biology Laboratory core funds. EOC was supported by project INTERACTOMA RTI2018-101205-B-I00 from the Spanish Agency of Science MICIU/AEI. S 887 GA and PS received additional funding by the project MAGGY (CTM2017-87736-R) from the Spanish Ministry of Economy and Competitiveness. The Malaspina 2010 Expedition was supported by the Spanish Ministry of Economy and Competitiveness (MINECO) through the Consolider-Ingenio program (ref. CSD2008-00077). The authors thank Johannes Söding and Alex Bateman for helpful discussions. Genes of unknown function are among the biggest challenges in molecular biology, especially in microbial systems, where 40%-60% of the predicted genes are unknown. Despite previous attempts, systematic approaches to include the unknown fraction into analytical workflows are still lacking. Here, we present a conceptual framework, its translation into the computational workflow AGNOSTOS and a demonstration on how we can bridge the known-unknown gap in genomes and metagenomes. By analyzing 415,971,742 genes predicted from 1,749 metagenomes and 28,941 bacterial and archaeal genomes, we quantify the extent of the unknown fraction, its diversity, and its relevance across multiple organisms and environments. The unknown sequence space is exceptionally diverse, phylogenetically more conserved than the known fraction and predominantly taxonomically restricted at the species level. From the 71M genes identified to be of unknown function, we compiled a collection of 283,874 lineage-specific genes of unknown function for Cand. Patescibacteria (also known as Candidate Phyla Radiation, CPR), which provides a significant resource to expand our understanding of their unusual biology. Finally, by identifying a target gene of unknown function for antibiotic resistance, we demonstrate how we can enable the generation of hypotheses that can be used to augment experimental data. 5 figures, 13 appendixes.-- Data availability: We used public data as described in the Methods section and Appendix 1-table 5.The code used for the analyses in the manuscript is available at https://github.com/functional-dark-side/functional-dark-side.github.io/tree/master/scripts. A list with the program versions can be found in https://github.com/functional-dark-side/functional-dark-side.github.io/blob/master/programs_and_versions.txt.The code to create the figures is available at https://github.com/functional-dark-side/vanni_et_al-figures, and the data for the figure can be downloaded from https://doi.org/10.6084/m9.figshare.12738476.v2. A reproducible version of the workflow is available at https://github.com/functional-dark-side/agnostos-wf.The data is publicly available at https://doi.org/10.6084/m9.figshare.12459056 With the institutional support of the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000928-S). Peer reviewed
MPG.PuRe arrow_drop_down Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information SystemRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . Peer-reviewedElectronic Publication Information CenterArticle . 2022Data sources: Electronic Publication Information Centeradd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.67667&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 10 citations 10 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 37visibility views 37 download downloads 132 Powered bymore_vert MPG.PuRe arrow_drop_down Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information SystemRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . Peer-reviewedElectronic Publication Information CenterArticle . 2022Data sources: Electronic Publication Information Centeradd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.67667&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Italy, Belgium, Netherlands, Denmark, France, BelgiumPublisher:Elsevier BV Funded by:EC | FUNDIVEUROPEEC| FUNDIVEUROPEXin Jing; Bart Muys; Lander Baeten; Helge Bruelheide; Hans De Wandeler; Ellen Desie; Stephan Hättenschwiler; Hervé Jactel; Bogdan Jaroszewicz; Tommaso Jucker; Paul Kardol; Martina Pollastrini; Sophia Ratcliffe; Michael Scherer-Lorenzen; Federico Selvi; Karen Vancampenhout; Fons van der Plas; Kris Verheyen; Lars Vesterdal; Juan Zuo; Koenraad Van Meerbeek;Tree species diversity promotes multiple ecosystem functions and services. However, little is known about how above- and belowground resource availability (light, nutrients, and water) and resource uptake capacity mediate tree species diversity effects on aboveground wood productivity and temporal stability of productivity in European forests and whether the effects differ between humid and arid regions. We used the data from six major European forest types along a latitudinal gradient to address those two questions. We found that neither leaf area index (a proxy for light uptake capacity), nor fine root biomass (a proxy for soil nutrient and water uptake capacity) was related to tree species richness. Leaf area index did, however, enhance productivity, but negatively affected stability. Productivity was further promoted by soil nutrient availability, while stability was enhanced by fine root biomass. We only found a positive effect of tree species richness on productivity in arid regions and a positive effect on stability in humid regions. This indicates a possible disconnection between productivity and stability regarding tree species richness effects. In other words, the mechanisms that drive the positive effects of tree species richness on productivity do not per se benefit stability simultaneously. Our findings therefore suggest that tree species richness effects are largely mediated by differences in climatic conditions rather than by differences in above- and belowground resource availability and uptake capacity at the regional scales. ispartof: SCIENCE OF THE TOTAL ENVIRONMENT vol:812 ispartof: location:Netherlands status: published
Mémoires en Sciences... arrow_drop_down Flore (Florence Research Repository)Article . 2022Data sources: Flore (Florence Research Repository)Flore (Florence Research Repository)Article . 2022Data sources: Flore (Florence Research Repository)Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information SystemGhent University Academic BibliographyArticle . 2022Data sources: Ghent University Academic Bibliographyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.scitotenv.2021.152560&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Mémoires en Sciences... arrow_drop_down Flore (Florence Research Repository)Article . 2022Data sources: Flore (Florence Research Repository)Flore (Florence Research Repository)Article . 2022Data sources: Flore (Florence Research Repository)Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information SystemGhent University Academic BibliographyArticle . 2022Data sources: Ghent University Academic Bibliographyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2023 DenmarkPublisher:Springer Science and Business Media LLC Funded by:EC | ERA4CS, NWO | Translating climate servi...EC| ERA4CS ,NWO| Translating climate service into personalized adaptation strategies to cope with thermal climate stress (ClimApp)Jakob Eggeling; Christofer Rydenfält; Amitava Halder; Jørn Toftum; Lars Nybo; Boris Kingma; Chuansi Gao;AbstractThe ClimApp smartphone application was developed to merge meteorological forecast data with personal information for individualized and improved thermal warning during heat and cold stress and for indoor comfort in buildings. For cold environments, ClimApp predicts the personal thermal stress and strain by the use of the Insulation REQuired model that combines weather and personal physiological data with additional consideration of the Wind Chill index based on the local weather forecast. In this study, we validated the individualized ClimApp index relative to measurements and compared it with the Universal Temperature Climate Index (UTCI). To this aim, 55 participants (27 females) were exposed to at least 1 h in an outdoor environment of 10 °C or below (average 1.4 °C air temperature, 74.9% relative humidity, and 4.7 m/s air velocity) inputting their activity level and clothing insulation as instructed by ClimApp. The UTCI and ClimApp indices were calculated and compared to the participants’ perceived thermal sensation. The ClimApp index root mean square deviation (RMSD) was below the standard deviation of the perceived thermal sensation which indicates a valid prediction and the UTCI RMSD was higher than the standard deviation which indicates an invalid prediction. The correlation of ClimApp and UTCI to the perceived thermal sensation was statistically significant for both models.
Copenhagen Universit... arrow_drop_down Copenhagen University Research Information SystemArticle . 2023Data sources: Copenhagen University Research Information SystemOnline Research Database In TechnologyArticle . 2023Data sources: Online Research Database In TechnologyInternational Journal of BiometeorologyArticle . 2023 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s00484-023-02553-w&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Copenhagen Universit... arrow_drop_down Copenhagen University Research Information SystemArticle . 2023Data sources: Copenhagen University Research Information SystemOnline Research Database In TechnologyArticle . 2023Data sources: Online Research Database In TechnologyInternational Journal of BiometeorologyArticle . 2023 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s00484-023-02553-w&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Preprint 2023 France, Denmark, United Kingdom, SwitzerlandPublisher:Copernicus GmbH Funded by:NSF | Biomass Burning, Dust, Se..., NSF | Collaborative Research: C..., EC | ICE&LASERS +4 projectsNSF| Biomass Burning, Dust, Sea Salt, Volcanic & Pollution Aerosols in the Arctic during the Last 2 Millennia: High Resolution Aerosol Records from NEEM & an Aray of Archived Ice Cores ,NSF| Collaborative Research: Continuous Records of Greenhouse Gases and Aerosol Deposition During the Holocene: Testing the Fidelity of New Methods for Reconstructing Atmospheric Change ,EC| ICE&LASERS ,EC| PEGASOS ,NSF| Development of High-Resolution, Multi-Century Records of Trace Element Deposition in West-Central Greenland Using ICP-MS ,NSF| Collaborative Research: Reconstruction of Carbon Monoxide in the Pre-Industrial Arctic Atmosphere from Ice Cores at Summit, Greenland ,NSF| PIRE: International Collaboration and Education in Ice Core Science (ICE-ICS)X. Faïn; D. M. Etheridge; D. M. Etheridge; K. Fourteau; P. Martinerie; C. M. Trudinger; C. M. Trudinger; R. H. Rhodes; N. J. Chellman; R. L. Langenfelds; J. R. McConnell; M. A. J. Curran; M. A. J. Curran; E. J. Brook; T. Blunier; G. Teste; R. Grilli; A. Lemoine; W. T. Sturges; B. Vannière; B. Vannière; J. Freitag; J. Chappellaz; J. Chappellaz;Abstract. Carbon monoxide (CO) is a naturally occurring atmospheric trace gas, a regulated pollutant, and one of the main components determining the oxidative capacity of the atmosphere. Evaluating climate–chemistry models under different conditions than today and constraining past CO sources requires a reliable record of atmospheric CO mixing ratios ([CO]) that includes data since preindustrial times. Here, we report the first continuous record of atmospheric [CO] for Southern Hemisphere (SH) high latitudes over the past 3 millennia. Our continuous record is a composite of three high-resolution Antarctic ice core gas records and firn air measurements from seven Antarctic locations. The ice core gas [CO] records were measured by continuous flow analysis (CFA), using an optical feedback cavity-enhanced absorption spectrometer (OF-CEAS), achieving excellent external precision (2.8–8.8 ppb; 2σ) and consistently low blanks (ranging from 4.1±1.2 to 7.4±1.4 ppb), thus enabling paleo-atmospheric interpretations. Six new firn air [CO] Antarctic datasets collected between 1993 and 2016 CE at the DE08-2, DSSW19K, DSSW20K, South Pole, Aurora Basin North (ABN), and Lock-In sites (and one previously published firn CO dataset at Berkner) were used to reconstruct the atmospheric history of CO from ∼1897 CE, using inverse modeling that incorporates the influence of gas transport in firn. Excellent consistency was observed between the youngest ice core gas [CO] and the [CO] from the base of the firn and between the recent firn [CO] and atmospheric [CO] measurements at Mawson station (eastern Antarctica), yielding a consistent and contiguous record of CO across these different archives. Our Antarctic [CO] record is relatively stable from −835 to 1500 CE, with mixing ratios within a 30–45 ppb range (2σ). There is a ∼5 ppb decrease in [CO] to a minimum at around 1700 CE during the Little Ice Age. CO mixing ratios then increase over time to reach a maximum of ∼54 ppb by ∼1985 CE. Most of the industrial period [CO] growth occurred between about 1940 to 1985 CE, after which there was an overall [CO] decrease, as observed in Greenland firn air and later at atmospheric monitoring sites and attributed partly to reduced CO emissions from combustion sources. Our Antarctic ice core gas CO observations differ from previously published records in two key aspects. First, our mixing ratios are significantly lower than reported previously, suggesting that previous studies underestimated blank contributions. Second, our new CO record does not show a maximum in the late 1800s. The absence of a [CO] peak around the turn of the century argues against there being a peak in Southern Hemisphere biomass burning at this time, which is in agreement with (i) other paleofire proxies such as ethane or acetylene and (ii) conclusions reached by paleofire modeling. The combined ice core and firn air [CO] history, spanning −835 to 1992 CE, extended to the present by the Mawson atmospheric record, provides a useful benchmark for future atmospheric chemistry modeling studies. International audience
Mémoires en Sciences... arrow_drop_down Copernicus Publications; Climate of the Past (CP)Other literature type . 2023Data sources: Copernicus Publicationshttps://doi.org/10.5194/cp-202...Preprint . 2023 . Peer-reviewedLicense: CC BYData sources: CrossrefInfoscience - EPFL scientific publicationsArticleData sources: Infoscience - EPFL scientific publicationsCopenhagen University Research Information SystemArticle . 2023Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5194/cp-2023-9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Mémoires en Sciences... arrow_drop_down Copernicus Publications; Climate of the Past (CP)Other literature type . 2023Data sources: Copernicus Publicationshttps://doi.org/10.5194/cp-202...Preprint . 2023 . Peer-reviewedLicense: CC BYData sources: CrossrefInfoscience - EPFL scientific publicationsArticleData sources: Infoscience - EPFL scientific publicationsCopenhagen University Research Information SystemArticle . 2023Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5194/cp-2023-9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Spain, DenmarkPublisher:Frontiers Media SA Funded by:EC | NOMORFILMEC| NOMORFILMAuthors: Nikoline Jensen; Henrik Elvang Jensen; Bent Aalbaek; Sophie Amalie Blirup-Plum; +19 AuthorsNikoline Jensen; Henrik Elvang Jensen; Bent Aalbaek; Sophie Amalie Blirup-Plum; Sara M. Soto; Sara M. Soto; Virginio Cepas; Yuly López; Yaiza Gabasa; Ignacio Gutiérrez-del-Río; Ignacio Gutiérrez-del-Río; Ignacio Gutiérrez-del-Río; Claudio J. Villar; Claudio J. Villar; Claudio J. Villar; Felipe Lombó; Felipe Lombó; Felipe Lombó; María José Iglesias; María José Iglesias; Raquel Soengas; Fernando López Ortiz; Louise Kruse Jensen;handle: 10651/67544
Chlorosphaerolactylate B, a newly discovered antimicrobial halometabolite from the cyanobacterium Sphaerospermopsis sp. LEGE 00249 has been synthesized in three steps by using 12-bromododecanoic acid as starting material. A total of 0.5 g was produced for in vitro and in vivo antimicrobial efficacy testing. In vitro, the minimal inhibitory concentration (MIC) was estimated to be 256 mg/L for Staphylococcus aureus, while the minimal biofilm inhibitory concentration (MBIC) was estimated to be 74 mg/L. The in vivo study utilized a porcine model of implant-associated osteomyelitis. In total, 12 female pigs were allocated into 3 groups based on inoculum (n = 4 in each group). An implant cavity (IC) was drilled in the right tibia and followed by inoculation and insertion of a steel implant. All pigs were inoculated with 10 μL containing either: 11.79 mg synthetic Chlorosphaerolactylate B + 104 CFU of S. aureus (Group A), 104 CFU of S. aureus (Group B), or pure saline (Group C), respectively. Pigs were euthanized five days after inoculation. All Group B animals showed macroscopic and microscopic signs of bone infection and both tissue and implant harbored S. aureus bacteria (mean CFU on implants = 1.9 × 105). In contrast, S. aureus could not be isolated from animals inoculated with saline. In Group A, two animals had a low number of S. aureus (CFU = 6.7 × 101 and 3.8 × 101, respectively) on the implants, otherwise all Group A animals were similar to Group C animals. In conclusion, synthetic Chlorosphaerolactylate B holds potential to be a novel antimicrobial and antibiofilm compound.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fmicb.2022.950855&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fmicb.2022.950855&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 Denmark, France, Austria, Italy, Germany, Russian Federation, Netherlands, France, Italy, Germany, Denmark, Brazil, Australia, Spain, Italy, Italy, Italy, FrancePublisher:Springer Science and Business Media LLC Funded by:EC | VERIFY, NSERC, NSF | Doctoral Dissertation Res... +11 projectsEC| VERIFY ,NSERC ,NSF| Doctoral Dissertation Research: Effects of a Dispersal Barrier on Cultural Similarity in Wild Orangutans (Pongo pygmaeus wurmbii) ,EC| CARE4C ,EC| T-FORCES ,UKRI| Amazon Integrated Carbon Analysis / AMAZONICA ,UKRI| Tropical Biomes in Transition ,EC| FUNDIVEUROPE ,NSF| BII-Implementation: The causes and consequences of plant biodiversity across scales in a rapidly changing world ,UKRI| RootDetect: Remote Detection and Precision Management of Root Health ,EC| OEMC ,EC| RESONATE ,UKRI| Tropical forests responses to a changing climate: a quest at the interface between trait-based ecology, forest dynamics and remote sensing ,NSF| CIF21 DIBBs: EI: Creating a Digital Environment for Enabling Data-Driven Science (DEEDS)Jingjing Liang; Javier G. P. Gamarra; Nicolas Picard; Mo Zhou; Bryan Pijanowski; Douglass F. Jacobs; Peter B. Reich; Thomas W. Crowther; Gert-Jan Nabuurs; Sergio de-Miguel; Jingyun Fang; Christopher W. Woodall; Jens-Christian Svenning; Tommaso Jucker; Jean-Francois Bastin; Susan K. Wiser; Ferry Slik; Bruno Hérault; Giorgio Alberti; Gunnar Keppel; Geerten M. Hengeveld; Pierre L. Ibisch; Carlos A. Silva; Hans ter Steege; Pablo L. Peri; David A. Coomes; Eric B. Searle; Klaus von Gadow; Bogdan Jaroszewicz; Akane O. Abbasi; Meinrad Abegg; Yves C. Adou Yao; Jesús Aguirre-Gutiérrez; Angelica M. Almeyda Zambrano; Jan Altman; Esteban Alvarez-Dávila; Juan Gabriel Álvarez-González; Luciana F. Alves; Bienvenu H. K. Amani; Christian A. Amani; Christian Ammer; Bhely Angoboy Ilondea; Clara Antón-Fernández; Valerio Avitabile; Gerardo A. Aymard; Akomian F. Azihou; Johan A. Baard; Timothy R. Baker; Radomir Balazy; Meredith L. Bastian; Rodrigue Batumike; Marijn Bauters; Hans Beeckman; Nithanel Mikael Hendrik Benu; Robert Bitariho; Pascal Boeckx; Jan Bogaert; Frans Bongers; Olivier Bouriaud; Pedro H. S. Brancalion; Susanne Brandl; Francis Q. Brearley; Jaime Briseno-Reyes; Eben N. Broadbent; Helge Bruelheide; Erwin Bulte; Ann Christine Catlin; Roberto Cazzolla Gatti; Ricardo G. César; Han Y. H. Chen; Chelsea Chisholm; Emil Cienciala; Gabriel D. Colletta; José Javier Corral-Rivas; Anibal Cuchietti; Aida Cuni-Sanchez; Javid A. Dar; Selvadurai Dayanandan; Thales de Haulleville; Mathieu Decuyper; Sylvain Delabye; Géraldine Derroire; Ben DeVries; John Diisi; Tran Van Do; Jiri Dolezal; Aurélie Dourdain; Graham P. Durrheim; Nestor Laurier Engone Obiang; Corneille E. N. Ewango; Teresa J. Eyre; Tom M. Fayle; Lethicia Flavine N. Feunang; Leena Finér; Markus Fischer; Jonas Fridman; Lorenzo Frizzera; André L. de Gasper; Damiano Gianelle; Henry B. Glick; Maria Socorro Gonzalez-Elizondo; Lev Gorenstein; Richard Habonayo; Olivier J. Hardy; David J. Harris; Andrew Hector; Andreas Hemp; Martin Herold; Annika Hillers; Wannes Hubau; Thomas Ibanez; Nobuo Imai; Gerard Imani; Andrzej M. Jagodzinski; Stepan Janecek; Vivian Kvist Johannsen; Carlos A. Joly; Blaise Jumbam; Banoho L. P. R. Kabelong; Goytom Abraha Kahsay; Viktor Karminov; Kuswata Kartawinata; Justin N. Kassi; Elizabeth Kearsley; Deborah K. Kennard; Sebastian Kepfer-Rojas; Mohammed Latif Khan; John N. Kigomo; Hyun Seok Kim; Carine Klauberg; Yannick Klomberg; Henn Korjus; Subashree Kothandaraman; Florian Kraxner; Amit Kumar; Relawan Kuswandi; Mait Lang; Michael J. Lawes; Rodrigo V. Leite; Geoffrey Lentner; Simon L. Lewis; Moses B. Libalah; Janvier Lisingo; Pablito Marcelo López-Serrano; Huicui Lu; Natalia V. Lukina; Anne Mette Lykke; Vincent Maicher; Brian S. Maitner; Eric Marcon; Andrew R. Marshall; Emanuel H. Martin; Olga Martynenko; Faustin M. Mbayu; Musingo T. E. Mbuvi; Jorge A. Meave; Cory Merow; Stanislaw Miscicki; Vanessa S. Moreno; Albert Morera; Sharif A. Mukul; Jörg C. Müller; Agustinus Murdjoko; Maria Guadalupe Nava-Miranda; Litonga Elias Ndive; Victor J. Neldner; Radovan V. Nevenic; Louis N. Nforbelie; Michael L. Ngoh; Anny E. N’Guessan; Michael R. Ngugi; Alain S. K. Ngute; Emile Narcisse N. Njila; Melanie C. Nyako; Thomas O. Ochuodho; Jacek Oleksyn; Alain Paquette; Elena I. Parfenova; Minjee Park; Marc Parren; Narayanaswamy Parthasarathy; Sebastian Pfautsch; Oliver L. Phillips; Maria T. F. Piedade; Daniel Piotto; Martina Pollastrini; Lourens Poorter; John R. Poulsen; Axel Dalberg Poulsen; Hans Pretzsch; Mirco Rodeghiero; Samir G. Rolim; Francesco Rovero; Ervan Rutishauser; Khosro Sagheb-Talebi; Purabi Saikia; Moses Nsanyi Sainge; Christian Salas-Eljatib; Antonello Salis; Peter Schall; Dmitry Schepaschenko; Michael Scherer-Lorenzen; Bernhard Schmid; Vladimír Šebeň; Giacomo Sellan; Federico Selvi; Josep M. Serra-Diaz; Douglas Sheil; Plinio Sist; Martin J. P. Sullivan; Miroslav Svoboda; Nadja Tchebakova; Robert Tropek; Peter Mbanda Umunay; Riccardo Valentini; Fons van der Plas; Hans Verbeeck; Alexander C. Vibrans; Jason Vleminckx; Catherine E. Waite; Chemuku Wekesa; Irie C. Zo-Bi; Cang Hui;pmid: 35941205
handle: 10459.1/84893 , 11585/915920 , 11390/1232984 , 10449/76215 , 2158/1279260 , 11541.2/30364 , 11572/351981
pmid: 35941205
handle: 10459.1/84893 , 11585/915920 , 11390/1232984 , 10449/76215 , 2158/1279260 , 11541.2/30364 , 11572/351981
The latitudinal diversity gradient (LDG) is one of the most recognized global patterns of species richness exhibited across a wide range of taxa. Numerous hypotheses have been proposed in the past two centuries to explain LDG, but rigorous tests of the drivers of LDGs have been limited by a lack of high-quality global species richness data. Here we produce a high-resolution (0.025° × 0.025°) map of local tree species richness using a global forest inventory database with individual tree information and local biophysical characteristics from ~1.3 million sample plots. We then quantify drivers of local tree species richness patterns across latitudes. Generally, annual mean temperature was a dominant predictor of tree species richness, which is most consistent with the metabolic theory of biodiversity (MTB). However, MTB underestimated LDG in the tropics, where high species richness was also moderated by topographic, soil and anthropogenic factors operating at local scales. Given that local landscape variables operate synergistically with bioclimatic factors in shaping the global LDG pattern, we suggest that MTB be extended to account for co-limitation by subordinate drivers. United States Department of Agriculture | Agricultural Research Service https://doi.org/10.13039/100007917 National Aeronautics and Space Administration https://doi.org/10.13039/100000104
Mémoires en Sciences... arrow_drop_down Nature Ecology & Evolution; Archivio istituzionale della ricerca - Fondazione Edmund Mach; Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) - Universidade de São Paulo (USP); PURE Aarhus University; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of TrentoArticle . 2022 . Peer-reviewedLicense: Springer TDMData sources: Archivio istituzionale della ricerca - Fondazione Edmund Mach; Crossref; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; NARCIS; PURE Aarhus University; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of TrentoArchiMer - Institutional Archive of IfremerOther literature type . 2022Data sources: ArchiMer - Institutional Archive of IfremerPublikationenserver der Georg-August-Universität GöttingenArticle . 2022GFZ German Research Centre for GeosciencesArticle . 2022Data sources: GFZ German Research Centre for GeosciencesArchiMer - Institutional Archive of IfremerOther literature type . 2022Data sources: ArchiMer - Institutional Archive of IfremerCopenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information SystemUniSA Research Outputs RepositoryArticle . 2022 . Peer-reviewedData sources: UniSA Research Outputs Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41559-022-01831-x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 24 citations 24 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Mémoires en Sciences... arrow_drop_down Nature Ecology & Evolution; Archivio istituzionale della ricerca - Fondazione Edmund Mach; Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) - Universidade de São Paulo (USP); PURE Aarhus University; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of TrentoArticle . 2022 . Peer-reviewedLicense: Springer TDMData sources: Archivio istituzionale della ricerca - Fondazione Edmund Mach; Crossref; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; NARCIS; PURE Aarhus University; Archivio istituzionale della ricerca - Università degli Studi di Udine; IRIS - Institutional Research Information System of the University of TrentoArchiMer - Institutional Archive of IfremerOther literature type . 2022Data sources: ArchiMer - Institutional Archive of IfremerPublikationenserver der Georg-August-Universität GöttingenArticle . 2022GFZ German Research Centre for GeosciencesArticle . 2022Data sources: GFZ German Research Centre for GeosciencesArchiMer - Institutional Archive of IfremerOther literature type . 2022Data sources: ArchiMer - Institutional Archive of IfremerCopenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information SystemUniSA Research Outputs RepositoryArticle . 2022 . Peer-reviewedData sources: UniSA Research Outputs Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41559-022-01831-x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Spain, DenmarkPublisher:Elsevier BV Funded by:EC | NOMORFILMEC| NOMORFILMAuthors: Louise Kruse Jensen; Henrik Elvang Jensen; Sophie Amalie Blirup-Plum; Mats Bue; +17 AuthorsLouise Kruse Jensen; Henrik Elvang Jensen; Sophie Amalie Blirup-Plum; Mats Bue; Pelle Hanberg; Lasse Kvich; Bent Aalbæk; Yuly López; Sara M. Soto; Marilina Douloudi; Michaela Papageorgiou; Eleni Nikoli; Michael Arkas; Ignacio Gutiérrez-del-Río; Sara López-Ibáñez; Claudio J. Villar; Felipe Lombó; Paraskevi Gkomoza; Ioanna Kitsou; Athina Tsetsekou; Michalis Vardavoulias;handle: 10651/66772
The use of bone implants and prostheses has contributed to a revolution in modern medicine; however, in the beginning, not much was asked from the implant and prosthetic materials per se. Therefore, the next game-changer in orthopedic research will come from new material designs which for instance can aid in prevention of implant-associated bone infections. Here, we describe the development of a new sol-gel coating technique that can deliver an efficient antimicrobial surface coating on orthopedic implants. Gentamicin was stocked in a novel nanocomposite xerogel made from silica and hyperbranched polyethyleneimine. The xerogel was anchored inside a porous surface made by coating of bone implants with titanium microspheres. Thereby, only the small water-soluble gentamicin molecules diffused in an aqueous environment, i.e., just after surgical insertion and leaving behind a titanium scaffold for osseointegration. The novel xerogel coating prevented development of severe Staphylococcus aureus induced osteomyelitis in a porcine model, which untreated, replicated the pathology seen in stage 3A on the Cierny–Mader classification system for osteomyelitis in adults.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.mtla.2022.101473&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.mtla.2022.101473&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Italy, DenmarkPublisher:Wiley Funded by:EC | COMPARE, NHMRC | Systems-based study, inte...EC| COMPARE ,NHMRC| Systems-based study, intervention, diagnosis and control of gastrointestinal parasitesGiulia I. Corsi; Swapnil Tichkule; Anna Rosa Sannella; Paolo Vatta; Francesco Asnicar; Nicola Segata; Aaron R. Jex; Cock van Oosterhout; Simone M. Cacciò;AbstractCryptosporidium parvum is a globally distributed zoonotic pathogen and a major cause of diarrhoeal disease in humans and ruminants. The parasite's life cycle comprises an obligatory sexual phase, during which genetic exchanges can occur between previously isolated lineages. Here, we compare 32 whole genome sequences from human‐ and ruminant‐derived parasite isolates collected across Europe, Egypt and China. We identify three strongly supported clusters that comprise a mix of isolates from different host species, geographic origins, and subtypes. We show that: (1) recombination occurs between ruminant isolates into human isolates; (2) these recombinant regions can be passed on to other human subtypes through gene flow and population admixture; (3) there have been multiple genetic exchanges, and most are probably recent; (4) putative virulence genes are significantly enriched within these genetic exchanges, and (5) this results in an increase in their nucleotide diversity. We carefully dissect the phylogenetic sequence of two genetic exchanges, illustrating the long‐term evolutionary consequences of these events. Our results suggest that increased globalization and close human‐animal contacts increase the opportunity for genetic exchanges between previously isolated parasite lineages, resulting in spillover and spillback events. We discuss how this can provide a novel substrate for natural selection at genes involved in host–parasite interactions, thereby potentially altering the dynamic coevolutionary equilibrium in the Red Queens arms race.
Molecular Ecology; I... arrow_drop_down Molecular Ecology; IRIS - Institutional Research Information System of the University of TrentoArticle . 2022 . Peer-reviewedLicense: CC BY NC NDCopenhagen University Research Information SystemArticle . 2023Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/mec.16556&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Molecular Ecology; I... arrow_drop_down Molecular Ecology; IRIS - Institutional Research Information System of the University of TrentoArticle . 2022 . Peer-reviewedLicense: CC BY NC NDCopenhagen University Research Information SystemArticle . 2023Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/mec.16556&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Denmark, SwedenPublisher:Elsevier BV Funded by:EC | DIVERSifyEC| DIVERSifyJames Ajal; Lars P. Kiær; Robin J. Pakeman; Christoph Scherber; Martin Weih;The relevance of intercropping, where two or more crop species are simultaneously grown on the same land space, is growing due to its potential for improving resource use and maintaining stable yields under variable weather conditions. However, the actual growth of intercropped species may differ resulting from the idiosyncratic effect of crop diversity, and with this, the realized benefits from intercrops are found to depend critically on the cultivar, species, management and environmental conditions. This study aimed to apply a trait-based approach, in which ecological niche spaces are defined through n-dimensional hypervolumes, to identify the contribution of species/cultivar, cultivation design (sole crop or intercrop) and management (low or high fertilization) to the trait diversity of four crop species, pea-barley and faba bean-wheat, when grown as sole crops and intercrops. Four traits were used as trait axes for the trait space analysis: canopy height, shoot biomass, tiller/node number, and grain yield. We found that trait spaces differed with crop species and cultivars, and whether they were grown as intercrops or sole crops. Trait spaces differed between high and low fertilization only for the cereals grown in the more productive site (i.e. Denmark). Species grown as intercrops had larger volumes than when grown as sole crops, as a result of trait plasticity. This response to intercropping was apparent in almost all the species grown in Sweden and Denmark, except for wheat in Denmark. The study demonstrated that individual species responded to intercropping compared to sole cropping through the plasticity of traits, which influenced the shape of the hypervolumes to divide up the trait space between the species. The findings are important in illustrating the plastic responses of arable crops, which are relevant for understanding the productivity of species grown in intercrops as compared to sole crops.
Epsilon Open Archive arrow_drop_down Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.baae.2022.03.009&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Epsilon Open Archive arrow_drop_down Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information Systemadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.baae.2022.03.009&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Denmark, NorwayPublisher:Springer Science and Business Media LLC Funded by:EC | ParaFishControlEC| ParaFishControlAina-Cathrine, Øvergård; Helena M D, Midtbø; Lars A, Hamre; Michael, Dondrup; Gro E K, Bjerga; Øivind, Larsen; Jiwan Kumar, Chettri; Kurt, Buchmann; Frank, Nilsen; Sindre, Grotmol;AbstractLittle is known about glandular proteins secreted from the skin- and blood-feeding ectoparasite salmon louse (Lepeophtheirus salmonis). The labial gland has ducts extending into the oral cavity of the lice, and the present study aimed to identify novel genes expressed by this gland type and to investigate their role in modulation of host parameters at the lice feeding site. Five genes associated with labial gland function were identified and named Lepeophteirus salmonis labial gland protein (LsLGP) 1–4 and 1 like (LsLGP1L). All LsLGPs were predicted to be small charged secreted proteins not encoding any known protein domains. Functional studies revealed that LsLGP1 and/or LsLGP1L regulated the expression of other labial gland genes. Immune dampening functions were indicated for LsLGP2 and 3. Whereas LsLGP2 was expressed throughout the parasitic life cycle and found to dampen inflammatory cytokines, LsLGP3 displayed an increased expression in mobile stages and appeared to dampen adaptive immune responses. Expression of LsLGP4 coincided with moulting to the mobile pre-adult I stage where hematophagous feeding is initiated, and synthetic LsLGP4 decreased the clotting time of Atlantic salmon plasma. Results from the present study confirm that the salmon louse secretes immune modulating and anti-coagulative proteins with a potential application in new immune based anti-salmon louse treatments.
Scientific Reports arrow_drop_down Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information SystemBergen Open Research Archive - UiB; Norwegian Open Research ArchivesArticle . 2022 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41598-022-11773-w&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Scientific Reports arrow_drop_down Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information SystemBergen Open Research Archive - UiB; Norwegian Open Research ArchivesArticle . 2022 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41598-022-11773-w&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Denmark, France, France, Germany, France, SpainPublisher:eLife Sciences Publications, Ltd Funded by:EC | INMAREEC| INMAREChiara Vanni; Matthew S Schechter; Silvia G Acinas; Albert Barberán; Pier Luigi Buttigieg; Emilio O Casamayor; Tom O Delmont; Carlos M Duarte; A Murat Eren; Robert D Finn; Renzo Kottmann; Alex Mitchell; Pablo Sánchez; Kimmo Siren; Martin Steinegger; Frank Oliver Gloeckner; Antonio Fernàndez-Guerra;The authors thankfully acknowledge the computer resources at MareNostrum and the technical support provided by Barcelona Supercomputing Center (RES-AECT-2014-2-0085), the BMBF877 funded de.NBI Cloud within the German Network for Bioinformatics Infrastructure (de.NBI) (031A537B, 031A533A, 031A538A, 031A533B, 031A535A, 031A537C, 031A534A, 031A532B), the University of Oxford Advanced Research Computing (http://dx.doi.org/10.5281/zenodo.22558) and the MARBITS bioinformatics core at ICM-CSIC.CV was supported by the Max Planck Society. AFG received funding from the European Union’s Horizon 2020 research and innovation program Blue Growth: Unlocking the potential of Seas and Oceans under grant agreement no. 634486 (project acronym INMARE). AM was supported by the Biotechnology and Biological Sciences Research Council [BB/M011755/1, BB/R015228/1] and RDF by the European Molecular Biology Laboratory core funds. EOC was supported by project INTERACTOMA RTI2018-101205-B-I00 from the Spanish Agency of Science MICIU/AEI. S 887 GA and PS received additional funding by the project MAGGY (CTM2017-87736-R) from the Spanish Ministry of Economy and Competitiveness. The Malaspina 2010 Expedition was supported by the Spanish Ministry of Economy and Competitiveness (MINECO) through the Consolider-Ingenio program (ref. CSD2008-00077). The authors thank Johannes Söding and Alex Bateman for helpful discussions. Genes of unknown function are among the biggest challenges in molecular biology, especially in microbial systems, where 40%-60% of the predicted genes are unknown. Despite previous attempts, systematic approaches to include the unknown fraction into analytical workflows are still lacking. Here, we present a conceptual framework, its translation into the computational workflow AGNOSTOS and a demonstration on how we can bridge the known-unknown gap in genomes and metagenomes. By analyzing 415,971,742 genes predicted from 1,749 metagenomes and 28,941 bacterial and archaeal genomes, we quantify the extent of the unknown fraction, its diversity, and its relevance across multiple organisms and environments. The unknown sequence space is exceptionally diverse, phylogenetically more conserved than the known fraction and predominantly taxonomically restricted at the species level. From the 71M genes identified to be of unknown function, we compiled a collection of 283,874 lineage-specific genes of unknown function for Cand. Patescibacteria (also known as Candidate Phyla Radiation, CPR), which provides a significant resource to expand our understanding of their unusual biology. Finally, by identifying a target gene of unknown function for antibiotic resistance, we demonstrate how we can enable the generation of hypotheses that can be used to augment experimental data. 5 figures, 13 appendixes.-- Data availability: We used public data as described in the Methods section and Appendix 1-table 5.The code used for the analyses in the manuscript is available at https://github.com/functional-dark-side/functional-dark-side.github.io/tree/master/scripts. A list with the program versions can be found in https://github.com/functional-dark-side/functional-dark-side.github.io/blob/master/programs_and_versions.txt.The code to create the figures is available at https://github.com/functional-dark-side/vanni_et_al-figures, and the data for the figure can be downloaded from https://doi.org/10.6084/m9.figshare.12738476.v2. A reproducible version of the workflow is available at https://github.com/functional-dark-side/agnostos-wf.The data is publicly available at https://doi.org/10.6084/m9.figshare.12459056 With the institutional support of the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000928-S). Peer reviewed
MPG.PuRe arrow_drop_down Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information SystemRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . Peer-reviewedElectronic Publication Information CenterArticle . 2022Data sources: Electronic Publication Information Centeradd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.67667&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 10 citations 10 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 37visibility views 37 download downloads 132 Powered bymore_vert MPG.PuRe arrow_drop_down Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information SystemRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . Peer-reviewedElectronic Publication Information CenterArticle . 2022Data sources: Electronic Publication Information Centeradd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.67667&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Italy, Belgium, Netherlands, Denmark, France, BelgiumPublisher:Elsevier BV Funded by:EC | FUNDIVEUROPEEC| FUNDIVEUROPEXin Jing; Bart Muys; Lander Baeten; Helge Bruelheide; Hans De Wandeler; Ellen Desie; Stephan Hättenschwiler; Hervé Jactel; Bogdan Jaroszewicz; Tommaso Jucker; Paul Kardol; Martina Pollastrini; Sophia Ratcliffe; Michael Scherer-Lorenzen; Federico Selvi; Karen Vancampenhout; Fons van der Plas; Kris Verheyen; Lars Vesterdal; Juan Zuo; Koenraad Van Meerbeek;Tree species diversity promotes multiple ecosystem functions and services. However, little is known about how above- and belowground resource availability (light, nutrients, and water) and resource uptake capacity mediate tree species diversity effects on aboveground wood productivity and temporal stability of productivity in European forests and whether the effects differ between humid and arid regions. We used the data from six major European forest types along a latitudinal gradient to address those two questions. We found that neither leaf area index (a proxy for light uptake capacity), nor fine root biomass (a proxy for soil nutrient and water uptake capacity) was related to tree species richness. Leaf area index did, however, enhance productivity, but negatively affected stability. Productivity was further promoted by soil nutrient availability, while stability was enhanced by fine root biomass. We only found a positive effect of tree species richness on productivity in arid regions and a positive effect on stability in humid regions. This indicates a possible disconnection between productivity and stability regarding tree species richness effects. In other words, the mechanisms that drive the positive effects of tree species richness on productivity do not per se benefit stability simultaneously. Our findings therefore suggest that tree species richness effects are largely mediated by differences in climatic conditions rather than by differences in above- and belowground resource availability and uptake capacity at the regional scales. ispartof: SCIENCE OF THE TOTAL ENVIRONMENT vol:812 ispartof: location:Netherlands status: published
Mémoires en Sciences... arrow_drop_down Flore (Florence Research Repository)Article . 2022Data sources: Flore (Florence Research Repository)Flore (Florence Research Repository)Article . 2022Data sources: Flore (Florence Research Repository)Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information SystemGhent University Academic BibliographyArticle . 2022Data sources: Ghent University Academic Bibliographyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.scitotenv.2021.152560&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Mémoires en Sciences... arrow_drop_down Flore (Florence Research Repository)Article . 2022Data sources: Flore (Florence Research Repository)Flore (Florence Research Repository)Article . 2022Data sources: Flore (Florence Research Repository)Copenhagen University Research Information SystemArticle . 2022Data sources: Copenhagen University Research Information SystemGhent University Academic BibliographyArticle . 2022Data sources: Ghent University Academic Bibliographyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.scitotenv.2021.152560&type=result"></script>'); --> </script>
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