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29 research outcomes, page 1 of 3
  • publication . Article . 2021
    Open Access English
    Authors:
    David Woods; Stephanie Flynn; José A. Caparrós-Martín; Stephen M. Stick; F. Jerry Reen; Fergal O'Gara;
    Persistent Identifiers
    Publisher: MDPI
    Project: SFI | Pre-clinical testing of n... (15/TIDA/2977), SFI | Next Generation Antibioti... (14/TIDA/2438), EC | INMARE (634486), SFI | Small molecule inhibitors... (13/TIDA/B2625)

    The study of the respiratory microbiota has revealed that the lungs of healthy and diseased individuals harbour distinct microbial communities. Imbalances in these communities can contribute to the pathogenesis of lung disease. How these imbalances occur and establish i...

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  • publication . Article . 2020
    Open Access
    Authors:
    Maria Schwarz; Edel J. Murphy; Aoife Foley; David Woods; Ignacio Abreu Castilla; F. Jerry Reen; Stuart G. Collins; Fergal O'Gara; Anita R. Maguire;
    Persistent Identifiers
    Publisher: Royal Society of Chemistry (RSC)
    Country: Ireland
    Project: EC | INMARE (634486), SFI | Small molecule inhibitors... (13/TIDA/B2625), SFI | Development of small mole... (12/TIDA/B2411), SFI | Optimised detection of ke... (12/TIDA/B2405), SFI | Pre-clinical testing of n... (15/TIDA/2977), SFI | An investigation of the m... (09/RFP/BMT2350), SFI | Process Flow Spectroscopy... (15/RI/3221), SFI | Synthesis and Solid State... (12/RC/2275), SFI | Next Generation Antibioti... (14/TIDA/2438)

    The marine transaminase, P-ω-TA, can be employed for the transamination from 1-aminotetralins and 1-aminoindanes with differentiation of stereochemistry at both the site of reaction and at a remote stereocentre resulting in formation of ketone products with up to 93% ee...

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  • publication . Article . 2020
    Open Access
    Authors:
    David Woods; Iwona M. Kozak; Fergal O'Gara;
    Persistent Identifiers
    Publisher: Frontiers Media SA
    Project: SFI | Next Generation Antibioti... (14/TIDA/2438), EC | INMARE (634486), SFI | Small molecule inhibitors... (13/TIDA/B2625), SFI | Development of small mole... (12/TIDA/B2411), SFI | Pre-clinical testing of n... (15/TIDA/2977), SFI | Optimised detection of ke... (12/TIDA/B2405), SFI | An investigation of the m... (09/RFP/BMT2350)

    Traditional food preservation processes are vital for the food industry. They not only preserve a high-quality protein and nutrient source but can also provide important value-added organoleptic properties. The Wiltshire process is a traditional food curing method appli...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Tarini Shankar Ghosh; Simone Rampelli; Ian B. Jeffery; Aurelia Santoro; Marta C Neto; Miriam Capri; Enrico Giampieri; Amy Jennings; Marco Candela; Silvia Turroni; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Countries: Netherlands, Italy, Finland, Italy, France, United Kingdom
    Project: EC | NU-AGE (266486), SFI | Development of Knowledge ... (13/SIRG/2128)

    ObjectiveAgeing is accompanied by deterioration of multiple bodily functions and inflammation, which collectively contribute to frailty. We and others have shown that frailty co-varies with alterations in the gut microbiota in a manner accelerated by consumption of a re...

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  • publication . Article . 2019
    Open Access
    Authors:
    Ramos, Ana F.; Woods, David F.; Shanahan, Rachel; Cano, Rafael; McGlacken, Gerard P.; Serra, Claudia; O'Gara, Fergal; Reen, F. Jerry;
    Persistent Identifiers
    Publisher: Microbiology Society
    Project: EC | INMARE (634486), SFI | Pre-clinical testing of n... (15/TIDA/2977)

    In recent years, the alkyl-quinolone molecular framework has already provided a rich source of bioactivity for the development of novel anti-infective compounds. Based on the quorum-sensing signalling molecules 4-hydroxy-2-heptylquinoline (HHQ) and 3,4-dihydroxy-2-hepty...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Gavin, D. P.; Reen, F. J.; Rocha-Martin, J.; Abreu-Castilla, I.; Woods, D. F.; Foley, A. M.; Sánchez-Murcia, P. A.; Schwarz, M.; O’Neill, P.; Maguire, A. R.; ...
    Publisher: Springer Nature Switzerland AG
    Countries: Ireland, Austria
    Project: SFI | Synthesis and Solid State... (12/RC/2275), SFI | Pre-clinical testing of n... (15/TIDA/2977), EC | INMARE (634486), FWF | Voltage-gated K+-channels... (M 2260)

    AbstractMicrobial enzymes from pristine niches can potentially deliver disruptive opportunities in synthetic routes to Active Pharmaceutical Ingredients and intermediates in the Pharmaceutical Industry. Advances in green chemistry technologies and the importance of ster...

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  • publication . Article . 2019
    Open Access English
    Authors:
    F. Jerry Reen; F. Jerry Reen; José A. Gutiérrez-Barranquero; Ronan R. McCarthy; David F. Woods; Sara Scarciglia; Claire Adams; Kristian Fog Nielsen; Lone Gram; Fergal O’Gara; ...
    Persistent Identifiers
    Publisher: Frontiers Media S.A.
    Countries: Denmark, United Kingdom, Ireland
    Project: EC | INMARE (634486), SFI | Pre-clinical testing of n... (15/TIDA/2977)

    Despite the discovery of the first N-acyl homoserine lactone (AHL) based quorum sensing (QS) in the marine environment, relatively little is known about the abundance, nature and diversity of AHL QS systems in this diverse ecosystem. Establishing the prevalence and dive...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Stephanie Flynn; F. Jerry Reen; Fergal O'Gara;
    Persistent Identifiers
    Publisher: Frontiers Media S.A.
    Country: Ireland
    Project: SFI | An investigation of the m... (09/RFP/BMT2350), EC | INMARE (634486), SFI | Pre-clinical testing of n... (15/TIDA/2977)

    The chronic colonization of the respiratory tract by the opportunistic pathogen Pseudomonas aeruginosa is the primary cause of morbidity and mortality in cystic fibrosis (CF) patients. P. aeruginosa has been shown to undergo extensive genomic adaptation facilitating its...

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  • publication . Article . 2019 . Embargo End Date: 26 Feb 2019
    Open Access English
    Authors:
    Gavin, Declan P.; Murphy, Edel J.; Foley, Aoife M.; Castilla, Ignacio Abreu; Reen, F. Jerry; Woods, David F.; Collins, Stuart G.; O'Gara, Fergal; Maguire, Anita R.;
    Persistent Identifiers
    Publisher: Wiley
    Country: Ireland
    Project: SFI | Pre-clinical testing of n... (15/TIDA/2977), EC | INMARE (634486), SFI | Small molecule inhibitors... (13/TIDA/B2625), SFI | An investigation of the m... (09/RFP/BMT2350), SFI | Development of small mole... (12/TIDA/B2411), SFI | Optimised detection of ke... (12/TIDA/B2405), SFI | Next Generation Antibioti... (14/TIDA/2438), SFI | Synthesis and Solid State... (12/RC/2275)

    Evaluation of an esterase annotated as 26D isolated from a marine metagenomic library is described. Esterase 26D was found to have a unique substrate scope, including synthetic transformations which could not be readily effected in a synthetically useful manner using co...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Haberlin, Damien; Raine, Robin; McAllen, Rob; Doyle, Thomas K.;
    Persistent Identifiers
    Publisher: Wiley
    Country: Ireland
    Project: SFI | Marine Renewable Energy I... (12/RC/2302), EC | CERES (678193)

    Abstract: Understanding how gelatinous zooplankton communities are structured by local hydrography and physical forcing has important implications for fisheries and higher trophic predators. Although a large body of research has described how fronts, hydrographic bounda...

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29 research outcomes, page 1 of 3