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SDSN - Greece Publications National Institutes of Health

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40 research outcomes, page 1 of 4
  • publication . Article . Other literature type . Preprint . 2020
    DNA-PKcs phosphorylation at the T2609 cluster alters the repair pathway choice during immunoglobulin class switch recombination
    Open Access
    Authors:
    Jennifer L. Crowe; Xiaobin S Wang; Zhengping Shao; Brian J. Lee; Verna M Estes; Shan Zha;
    Persistent Identifiers

    doi: 10.1073/pnas.2007455117 , 10.1101/2020.04.23.057877

    pmc: PMC7502750

    pmid: 32868446

    Publisher: Proceedings of the National Academy of Sciences
    Project: EC | SCALES (226852), NIH | The catalytic and non-cat... (1R01CA226852-01), NIH | CANCER CENTER CORE SUPPOR... (3P30CA013696-21S1), NIH | Non-catalytic functions o... (1F31CA183504-01A1), NIH | Clinical and Translationa... (5TL1TR000082-08), NIH | DNA-PKCS Phosphorylation ... (1R01CA184187-01A1), NIH | The Role of ATM in Suppre... (5R01CA158073-05)

    AbstractThe DNA-dependent protein kinase (DNA-PK), composed of the KU heterodimer and the large catalytic subunit (DNA-PKcs), is a classical non-homologous end-joining (cNHEJ) factor. Naïve B cells undergo class switch recombination (CSR) to generate antibodies with dif...

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  • publication . Article . 2020
    Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment
    Open Access English
    Authors:
    Elina Drakvik; Rolf Altenburger; Yasunobu Aoki; Thomas Backhaus; Tina Bahadori; Robert Barouki; Werner Brack; Mark T.D. Cronin; Barbara Demeneix; Susanne Hougaard Bennekou; ...
    Persistent Identifiers

    doi: 10.18154/rwth-2020-01860 , 10.1016/j.envint.2019.105267

    handle: 1887/85788 , 1874/411651 , 2066/216989 , 10029/623606

    pmc: PMC6979318

    pmid: 31704565

    Countries: Denmark, United Kingdom, Netherlands, Germany, Sweden
    Project: EC | HBM4EU (733032), EC | SOLUTIONS (603437), EC | EuroMix (633172), EC | EU-ToxRisk (681002), EC | EDC-MixRisk (634880), NIH | Toxicological Assessments... (1ZIAES103316-02)

    Environment international 134, 105267 (2020). doi:10.1016/j.envint.2019.105267

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  • publication . Article . 2019
    Diet as a Source of Exposure to Environmental Contaminants for Pregnant Women and Children from Six European Countries.
    Open Access
    Authors:
    Eleni Papadopoulou; Line Småstuen Haug; Amrit Kaur Sakhi; Sandra Andrusaityte; Xavier Basagaña; Anne Lise Brantsæter; Maribel Casas; Sílvia Fernández-Barrés; Regina Grazuleviciene; Helle Katrine Knutsen; ...
    Persistent Identifiers

    doi: 10.1289/ehp5324

    pmc: PMC6867312

    pmid: 31617753

    Publisher: Environmental Health Perspectives
    Countries: Norway, Spain, France, France
    Project: NIH | Pilot Project Program (5P30ES007048-17), EC | ENRIECO (226285), EC | ESCAPE (211250), EC | HELIX (308333)

    Background: Pregnant women and children are especially vulnerable to exposures to food contaminants, and a balanced diet during these periods is critical for optimal nutritional status. Objectives: Our objective was to study the association between diet and measured blo...

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  • publication . Article . 2019
    Association of exposure to ambient air pollution with thyroid function during pregnancy
    Open Access
    Authors:
    Akhgar Ghassabian; Livia Pierotti; Mikel Basterrechea; Leda Chatzi; Marisa Estarlich; Ana Fernández-Somoano; Abby F. Fleisch; Diane R. Gold; Jordi Julvez; Polyxeni Karakosta; ...
    Persistent Identifiers

    doi: 10.1001/jamanetworkopen.2019.12902 , 10.1530/ey.17.3.4

    pmc: PMC6806433

    pmid: 31617922

    handle: 10651/53754

    Publisher: American Medical Association
    Countries: Spain, Spain, Netherlands, Spain
    Project: EC | ESCAPE (211250), EC | ENRIECO (226285), NIH | Common and distinct early... (4UH3OD023286-03), NIH | Air Pollution Exposure du... (5K23ES024803-04), EC | DENAMIC (282957)

    Importance Air pollutants interact with estrogen nuclear receptors, but their effect on thyroid signaling is less clear. Thyroid function is of particular importance for pregnant women because of the thyroid’s role in fetal brain development. Objective To determine the ...

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  • publication . Article . 2019
    Prenatal Particulate Air Pollution and DNA Methylation in Newborns: An Epigenome-Wide Meta-Analysis
    Open Access English
    Authors:
    Gruzieva, Olena; Xu, Cheng-Jian; Yousefi, Paul; Relton, Caroline; Merid, Simon Kebede; Breton, Carrie V.; Gao, Lu; Volk, Heather E.; Feinberg, Jason I.; Ladd-Acosta, Christine; ...
    Persistent Identifiers

    doi: 10.1289/ehp4522

    pmc: PMC6792178

    pmid: 31148503

    handle: 1765/117850 , 1983/dac8f7b9-b02b-4597-8509-6ced04a918a3 , 10261/213602

    Publisher: Environmental Health Perspectives
    Countries: France, Spain, Spain, Netherlands, Finland, Norway, Italy, Belgium, United Kingdom, France ...
    Project: NIH | AIR POLLUTION AND IMPLANT... (5P01ES009825-03), EC | ESCAPE (211250), NIH | Novel Epigenomic Biomarke... (1R01NR013945-01), UKRI | Accessible resource for i... (BB/I025263/1), NIH | Prospective Evaluation of... (3R01ES023780-04S1), EC | EXPOSOMICS (308610), NIH | Early Autism Risk Longitu... (5R01ES016443-03), NIH | Patient-oriented Research... (5K24HD069408-05), NIH | The Toxic Environment and... (5K23ES022242-05), EC | EMBRYOandLATERHEALTH (648916),...

    The UK Medical Research Council and the Wellcome Trust (Grant ref. 102215/2/13/2) provides core support for ALSPAC. A comprehensive list of grants funding is available on the ALSPAC website (http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf)....

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  • publication . Article . 2019
    Influence of the Urban Exposome on Birth Weight
    Open Access English
    Authors:
    Nieuwenhuijsen, Mark J.; Agier, Lydiane; Basagana, Xavier; Urquiza, Jose; TAMAYO-URIA, Ibon; GIORGIS-ALLEMAND, Lise; ROBINSON, Oliver; Siroux, Valérie; MAITRE, Léa; De Castro, Montserrat; ...
    Persistent Identifiers

    doi: 10.1289/ehp3971

    pmc: PMC6785228

    pmid: 31009264

    Countries: France, United Kingdom, France, Netherlands, Spain, Norway, Australia
    Project: EC | ESCAPE (211250), NIH | Pilot Project Program (5P30ES007048-17), EC | ENRIECO (226285), EC | HELIX (308333)

    Background: The exposome is defined as the totality of environmental exposures from conception onwards. It calls for providing a holistic view of environmental exposures and their effects on human health by evaluating multiple environmental exposures simultaneously duri...

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  • publication . Article . 2019
    Early-life exposome and lung function in children in Europe: an analysis of data from the longitudinal, population-based HELIX cohort
    Open Access English
    Authors:
    Agier, Lydiane; Basagaña Flores, Xavier; Maitre, Lea; Granum, Berit; Bird, Philippa K.; Casas Sanahuja, Maribel; Oftedal, Bente; Wright, John; Andrusaityte, Sandra; de Castro, Montserrat; ...
    Persistent Identifiers

    handle: 10459.1/68496

    Countries: France, United Kingdom, Netherlands, Australia, Spain, France, Spain
    Project: NIH | Pilot Project Program (5P30ES007048-17), EC | ENRIECO (226285), EC | HELIX (308333), EC | ESCAPE (211250)

    International audience; Background: Several single-exposure studies have documented possible effects of environmental factors on lung function, but none has relied on an exposome approach. We aimed to evaluate the association between a broad range of prenatal and postna...

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  • publication . Article . 2019
    The early-life exposome: description and patterns in six European countries
    Open Access
    Authors:
    Tamayo-Uria, Ibon; Maitre, Léa; Thomsen, Cathrine; Nieuwenhuijsen, Mark J.; Chatzi, Leda; Siroux, Valérie; Aasvang, Gunn Marit; Agier, Lydiane; Andrusaityte, Sandra; Casas, Maribel; ...
    Persistent Identifiers

    doi: 10.1016/j.envint.2018.11.067

    Publisher: Elsevier
    Countries: Spain, France, France, France, United Kingdom, Spain, Australia
    Project: NIH | Pilot Project Program (5P30ES007048-17), EC | ENRIECO (226285), EC | ESCAPE (211250), NIH | Gene-Environment Interact... (5U01NS047537-04), EC | HELIX (308333)

    Characterization of the "exposome", the set of all environmental factors that one is exposed to from conception onwards, has been advocated to better understand the role of environmental factors on chronic diseases. Here, we aimed to describe the early-life exposome. Sp...

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  • publication . Article . 2018
    Gestational weight gain charts for different body mass index groups for women in Europe, North America and Oceania
    Open Access English
    Authors:
    Santos, Susana; Eekhout, Iris; Voerman, Ellis; Gaillard, Romy; Barros, Henrique; Charles, Marie-Aline; Chatzi, Leda; Chevrier, Cécile; Chrousos, George P; Corpeleijn, Eva; ...
    Persistent Identifiers

    doi: 10.1186/s12916-018-1189-1

    handle: 20.500.13003/9026 , 1983/bf5134a8-f2b0-47df-b2fc-65dabbfd8800 , 1765/112067 , 1874/375501 , 2066/197956 , 11370/a567cd67-fc1b-4508-b9d3-40d069651d82 , 1874/373239 , 1956/19257 , 10146/618258

    pmc: PMC6217770

    pmid: 30396358

    Countries: Poland, Germany, Spain, Netherlands, Spain, United Kingdom, Spain, Norway, Netherlands, Italy ...
    Project: AKA | Recurrent respiratory inf... (123571), NIH | PCBs and Otodevelopment i... (1R03TW007152-01A1), NIH | Developmental effects of ... (5R01ES015282-04), EC | ENRIECO (226285), NIH | Early Childhood Developme... (5R01CA096525-03), NIH | Common and distinct early... (5UG3OD023286-02), EC | ESCAPE (211250), NIH | VULNERABILITY OF THE FETU... (5R01ES010165-02), NIH | Women's Health and the En... (5K12ES019852-03), AKA | Prospective longitudinal ... (121569),...

    ABCDr This work was supported by the Netherlands Organization for Health Research and Development (ZonMw) (TOP grant, 40-00812-98-11010).r ALSPACr The UK Medical Research Council and Wellcome (Grant ref.: 102215/2/13/2) and the University of Bristol provide core support...

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  • publication . Article . 2018
    Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer
    Open Access
    Authors:
    Durand, Joel; Zhang, Qing; Baldwin, Albert;
    Persistent Identifiers

    doi: 10.3390/cells7090139

    pmc: PMC6162516

    pmid: 30223576

    Publisher: MDPI AG
    Project: NIH | Exploration of ZHX2 as a ... (1R01CA211732-01A1), NIH | IKK/NF-kappaB Signaling i... (5R35CA197684-02)

    While primarily studied for their roles in innate immune response, the IκB kinase (IKK)-related kinases TANK-binding kinase 1 (TBK1) and IKKε also promote the oncogenic phenotype in a variety of cancers. Additionally, several substrates of these kinases co...

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40 research outcomes, page 1 of 4