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description Publicationkeyboard_double_arrow_right Article , Other literature type 2011 United Kingdom, Spain, Australia, Croatia, NetherlandsPublisher:Springer Science and Business Media LLC Funded by:NIH | Diabetes Endocrinology Re..., MZOS | Complex traits variation ..., AKA | Identification of new gen... +45 projectsNIH| Diabetes Endocrinology Research Center ,MZOS| Complex traits variation and health in children, adults and centenarians ,AKA| Identification of new genes for type 2 diabetes ,NIH| INSULINOPENIC TYPE 2 DIABETES IN HISPANICS ,NIH| Genome-wide Search for CVD Gene-Environment Interactions ,EC| FULL4HEALTH ,AKA| Public Health Genomics to Practice in Cardiovascular Diseases / Consortium: PUBGENSENS ,NIH| CHS-Transition Phase -268055222 ,NIH| CHS Events Follow-up Study ,NIH| CANDIDATE GENE STUDIES OF OBESITY GUIDED BY WHOLE GENOME ASSOCIATION DATA ,SNSF| Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study ,NIH| Longevity Genes in Founder Populations ,NIH| CORE--ADIPOSE TISSUE BIOLOGY AND BASIC MECHANISMS ,EC| PREPOBEDIA ,NIH| THE FRAMINGHAM HEART STUDY-268025195 ,NIH| CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS ,NIH| CHS-ULTRASOUND READING ,AKA| Center of Excellence in Complex Disease Genetics ,NIH| CARDIOVASCULAR HEALTH STUDY--ECHOCARDIOGRAPHY ,NIH| MRI READING CENTER FOR THE CARDIOVASCULAR HEALTH STUDY ,EC| ENGAGE ,SNSF| Contribution of the nuclear receptor protein ESRRgamma to insulin-secreting beta cell function ,NIH| WGA Study to Identify Genetic Variants Associated with CV Events in CHS ,NIH| SOCIAL AND OCCUPATIONAL INFLUENCES ON HEALTH AND ILLNESS ,NIH| CHS RETINAL READING CENTER ,NIH| Analysis of Fatty Liver in the Framingham Heart Study Cohort ,NIH| CORONARY HEART DISEASE AND STROKE ,WT| Genomics of quantitative variation. ,NIH| AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-260012100 ,NIH| Genome-wide Association in Families: Data Integrity, Design and Methods Issue ,WT| Identification of genetic variants underlying coronary artery disease and associated phenotypes in Indian Asians. ,NIH| Genetic Influences on Coronary Artery Calcification ,SNSF| From modules to models: towards a better understanding of disease through advanced analysis of large-scale data ,NIH| GENETICS OF OSTEOPOROSIS IN THE AMISH ,NIH| Genetic Determinants of Visceral Adiposity ,AKA| CoE in Complex Disease Genetics ,NWO| NCHA Subsidiebesluit 2008-2012 ,NIH| DYNAMICS OF HEALTH, AGING, AND BODY COMPOSITION-260962103 ,NIH| HEALTH ABC--COORDINATING UNIT-260962106 ,NIH| CHANGES IN HEALTH: SOCIO-ECONOMIC STATUS AND PATHWAYS ,WT| Genetic studies of the aetiology of human metabolic disease: morbid obesity, obesity, severe insulin resistance and type 2 diabetes. ,EC| HYPERGENES ,NIH| ATN 004: HEALTHY CHOICES: MOTIVATIONAL ENHANCEMENT TO PROMOTE HEALTH AND REDU ,NIH| Epidemiology of IGF's and Aging ,EC| GEFOS ,AKA| The relation of diet, metabolism and genetic factors to obesity, abdominal obesity and weight gain: An epidemiological approach ,NIH| DYNAMICS OF HEALTH .AGING . AND BODY COMPOSITION /Pittsburgh/-260962101 ,MZOS| Determinants of health and disease in general and isolated human populationsAuthors: Tuomas O. Kilpeläinen; M. Carola Zillikens; Alena Stančáková; Francis M. Finucane; +113 AuthorsTuomas O. Kilpeläinen; M. Carola Zillikens; Alena Stančáková; Francis M. Finucane; Janina S. Ried; Claudia Langenberg; Weihua Zhang; Jacques S. Beckmann; Jian'an Luan; Liesbeth Vandenput; Unnur Styrkarsdottir; Yanhua Zhou; Albert V. Smith; Jing Hua Zhao; Najaf Amin; Sailaja Vedantam; So-Youn Shin; Talin Haritunians; Mao Fu; Mary F. Feitosa; Meena Kumari; Bjarni V. Halldorsson; Emmi Tikkanen; Massimo Mangino; Caroline Hayward; Ci Song; Alice M. Arnold; Yurii S. Aulchenko; Ben A. Oostra; Harry Campbell; L. Adrienne Cupples; Kathryn Davis; Angela Döring; Gudny Eiriksdottir; Karol Estrada; José Manuel Fernández-Real; Melissa Garcia; Christian Gieger; Nicole L. Glazer; Candace Guiducci; Albert Hofman; Steve E. Humphries; Bo Isomaa; Leonie C. Jacobs; Antti Jula; David Karasik; Magnus Karlsson; Kay-Tee Khaw; Lauren J. Kim; Mika Kivimäki; Norman Klopp; Brigitte Kühnel; Johanna Kuusisto; Yongmei Liu; Östen Ljunggren; Mattias Lorentzon; Robert Luben; Barbara McKnight; Dan Mellström; Braxton D. Mitchell; Vincent Mooser; José María Moreno; Satu Männistö; Jeffery R. O'Connell; Laura Pascoe; Leena Peltonen; Belén Peral; Markus Perola; Bruce M. Psaty; Veikko Salomaa; David B. Savage; Robert K. Semple; Tatjana Škarić-Jurić; Gunnar Sigurdsson; Kijoung Song; Tim D. Spector; Ann-Christine Syvänen; Philippa J. Talmud; Gudmar Thorleifsson; Unnur Thorsteinsdottir; André G. Uitterlinden; Cornelia M. van Duijn; Antonio Vidal-Puig; Sarah H. Wild; Alan F. Wright; Deborah J. Clegg; Eric E. Schadt; James F. Wilson; Igor Rudan; Samuli Ripatti; Ingrid B. Borecki; Alan R. Shuldiner; Erik Ingelsson; John-Olov Jansson; Robert C. Kaplan; Vilmundur Gudnason; Tamara B. Harris; Leif Groop; Douglas P. Kiel; Fernando Rivadeneira; Mark Walker; Inês Barroso; Peter Vollenweider; Gérard Waeber; John C. Chambers; Jaspal S. Kooner; Nicole Soranzo; Joel N. Hirschhorn; Kari Stefansson; H-Erich Wichmann; Claes Ohlsson; Stephen O'Rahilly; Nicholas J. Wareham; Elizabeth K. Speliotes; Caroline S. Fox; Markku Laakso; Ruth J. F. Loos;Finnish Diabetes Foundation; Finnish Diabetes Research Foundation; Finnish Foundation for Cardiovascular Research; Finnish Heart Foundation; Finnish Medical Society; Folkhälsan Research Foundation; Food Standards Agency (UK); Foundation for Life and Health in Finland; German Bündesministerium für Forschung und Technology (01AK803A-H and 01IG07015G); German Federal Ministry of Education and Research; German National Genome Research Network (NGFN-2 and NGFNPlus: 01GS0823); Giorgi-Cavaglieri Foundation; GlaxoSmithKline; Göteborg Medical Society; Gyllenberg Foundation; Health and Safety Executive (UK); Health Care Centers in Vasa, Närpes and Korsholm; Hjartavernd (the Icelandic Heart Association); John D. and Catherine T. MacArthur Foundation; Knut and Alice Wallenberg Foundation; Leenaards Foundation; Ludwig-Maximilians Universität München; Lundberg Foundation; Medical Research Council (UK); Men’s Associates of Hebrew SeniorLife; Ministerio de Ciencia e Innovación (Spain) (SAF-2009 and SAF-2008-02073); Ministry for Health, Welfare and Sports (The Netherlands); Ministry of Education (Finland); Ministry of Education, Culture and Science (The Netherlands); Municipal Health Care Center and Hospital in Jakobstad; Municipality of Rotterdam; Närpes Health Care Foundation; National Institute for Health Research (UK); US National Institutes of Health (USA) (AG13196, DK063491, K23-DK080145, M01-RR00425, N01-AG12100, N01-AG62101, N01-AG62103, N01-AG62106, N01-HC15103, N01-HC25195, N01-HC35129, N01-HC45133, N01-HC55222, N01-HC75150, N01- HC85079 through N01-HC85086, P30-DK072488, R01-AG031890-01, R01-AG18728, R01-AG032098-01A1, R01-AR/AG41398, R01-AR046838, R01-DK06833603, R01-DK075787, R01-DK07568102, R01-HL036310-20A2, R01-HL087652, R01-HL08770003, R01-HL088119, U01-HL080295, U01-HL72515 and U01-HL84756); Netherlands Genomics Initiative/Netherlands Consortium for Healthy Aging (050-060-810); Netherlands Organisation for Scientific Research (175.010.2005.011 and 911-03-012); Netherlands Organization for the Health Research and Development; Nordic Center of Excellence in Disease Genetics; Novo Nordisk Foundation; Ollqvist Foundation; Paavo Nurmi Foundation; Perklén Foundation; Petrus and Augusta Hedlunds Foundation; Research Institute for Diseases in the Elderly (014-93-015; RIDE2); Robert Dawson Evans Endowment; Royal Society (UK); Sahlgrenska Center for Cardiovascular and Metabolic Research (A305:188); Sahlgrenska University Hospital Foundation (ALF/LUA); Science Funding programme (UK); Scottish Executive Health Department; Sigrid Juselius Foundation; State of Bavaria; Stroke Association (UK); Swedish Cultural Foundation in Finland; Swedish Foundation for Strategic Research; Swedish Research Council (K2010-54X-09894-19-3, K2010-52X-20229-05-3 and 2006-3832); Swedish Strategic Foundation; Swiss Institute of Bioinformatics; Swiss National Science Foundation (3100AO-116323/1, 310000-112552 and 33CSCO-122661); TEKES (1510/31/06); Torsten and Ragnar Söderberg’s Foundation; United Kingdom NIHR Cambridge Biomedical Research Centre; University of Lausanne; University of Maryland General Clinical Research Center (M01 RR 16500); Uppsala University; Västra Götaland Foundation; and Wellcome Trust (077016/Z/05/Z, 084723/Z/08/Z and 091746/Z/10/Z). Funding was provided by Academy of Finland (10404, 124243, 129680, 129494, 141005 and 213506); Agency for Health Care Policy Research (HS06516); Althingi (the Icelandic Parliament); American Heart Association (10SDG269004); AstraZeneca; Baltimore Geriatric Research Education and Clinical Centers; Biocentrum Helsinki Foundation; Biotechnology and Biological Sciences Research Council (G20234); British Heart Foundation (PG/07/133/24260, RG/08/008, SP/04/002, SP/07/007/23671); CamStrad; Cancer Research UK; Cedars-Sinai Board of Governors’ Chair in Medical Genetics; Centre for Medical Systems Biology (The Netherlands); Centre Hospitalier Universitaire Vaudois (Lausanne); Croatian Ministry of Science, Education and Sport (196-1962766-2747, 216-1080315-0302 and 309-0061194-2023); Department of Health (UK); Department of Veterans Affairs (USA); Emil and Vera Cornell Foundation; Erasmus Medical Center (Rotterdam); Erasmus University (Rotterdam); European Commission (DG XII, FP7/2007-2013, FP7-KBBE-2010-4-266408, HEALTH-F2-2007-201681, HEALTH-F2-2008-201865-GEFOS, HEALTH-F4-2007-201413, HEALTH-F4-2007-201550, LSHG-CT-2006-018947, LSHG-CT-2006-01947, LSHM-CT-2003-503041, LSHM-CT-2004-512013, QLG1-CT-2001-01252 and QLG2-CT-2002-01254) Genome-wide association studies have identified 32 loci influencing body mass index, but this measure does not distinguish lean from fat mass. To identify adiposity loci, we meta-analyzed associations between ~2.5 million SNPs and body fat percentage from 36,626 individuals and followed up the 14 most significant (P < 10−6) independent loci in 39,576 individuals. We confirmed a previously established adiposity locus in FTO (P = 3 × 10−26) and identified two new loci associated with body fat percentage, one near IRS1 (P = 4 × 10−11) and one near SPRY2 (P = 3 × 10−8). Both loci contain genes with potential links to adipocyte physiology. Notably, the body-fat–decreasing allele near IRS1 is associated with decreased IRS1 expression and with an impaired metabolic profile, including an increased visceral to subcutaneous fat ratio, insulin resistance, dyslipidemia, risk of diabetes and coronary artery disease and decreased adiponectin levels. Our findings provide new insights into adiposity and insulin resistance. El pdf del artículo es el manuscrito de autor: PMC3262230.-- et al. Peer reviewed
Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2011 . Peer-reviewedCroatian Scientific Bibliography - CROSBIArticle . 2011Data sources: Croatian Scientific Bibliography - CROSBIadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 300 citations 300 popularity Top 1% influence Top 1% impulse Top 1% Powered by BIP!visibility 23visibility views 23 download downloads 45 Powered bymore_vert Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2011 . Peer-reviewedCroatian Scientific Bibliography - CROSBIArticle . 2011Data sources: Croatian Scientific Bibliography - CROSBIadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article , Other literature type 2011 United Kingdom, Spain, Australia, Croatia, NetherlandsPublisher:Springer Science and Business Media LLC Funded by:NIH | Diabetes Endocrinology Re..., MZOS | Complex traits variation ..., AKA | Identification of new gen... +45 projectsNIH| Diabetes Endocrinology Research Center ,MZOS| Complex traits variation and health in children, adults and centenarians ,AKA| Identification of new genes for type 2 diabetes ,NIH| INSULINOPENIC TYPE 2 DIABETES IN HISPANICS ,NIH| Genome-wide Search for CVD Gene-Environment Interactions ,EC| FULL4HEALTH ,AKA| Public Health Genomics to Practice in Cardiovascular Diseases / Consortium: PUBGENSENS ,NIH| CHS-Transition Phase -268055222 ,NIH| CHS Events Follow-up Study ,NIH| CANDIDATE GENE STUDIES OF OBESITY GUIDED BY WHOLE GENOME ASSOCIATION DATA ,SNSF| Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study ,NIH| Longevity Genes in Founder Populations ,NIH| CORE--ADIPOSE TISSUE BIOLOGY AND BASIC MECHANISMS ,EC| PREPOBEDIA ,NIH| THE FRAMINGHAM HEART STUDY-268025195 ,NIH| CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS ,NIH| CHS-ULTRASOUND READING ,AKA| Center of Excellence in Complex Disease Genetics ,NIH| CARDIOVASCULAR HEALTH STUDY--ECHOCARDIOGRAPHY ,NIH| MRI READING CENTER FOR THE CARDIOVASCULAR HEALTH STUDY ,EC| ENGAGE ,SNSF| Contribution of the nuclear receptor protein ESRRgamma to insulin-secreting beta cell function ,NIH| WGA Study to Identify Genetic Variants Associated with CV Events in CHS ,NIH| SOCIAL AND OCCUPATIONAL INFLUENCES ON HEALTH AND ILLNESS ,NIH| CHS RETINAL READING CENTER ,NIH| Analysis of Fatty Liver in the Framingham Heart Study Cohort ,NIH| CORONARY HEART DISEASE AND STROKE ,WT| Genomics of quantitative variation. ,NIH| AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-260012100 ,NIH| Genome-wide Association in Families: Data Integrity, Design and Methods Issue ,WT| Identification of genetic variants underlying coronary artery disease and associated phenotypes in Indian Asians. ,NIH| Genetic Influences on Coronary Artery Calcification ,SNSF| From modules to models: towards a better understanding of disease through advanced analysis of large-scale data ,NIH| GENETICS OF OSTEOPOROSIS IN THE AMISH ,NIH| Genetic Determinants of Visceral Adiposity ,AKA| CoE in Complex Disease Genetics ,NWO| NCHA Subsidiebesluit 2008-2012 ,NIH| DYNAMICS OF HEALTH, AGING, AND BODY COMPOSITION-260962103 ,NIH| HEALTH ABC--COORDINATING UNIT-260962106 ,NIH| CHANGES IN HEALTH: SOCIO-ECONOMIC STATUS AND PATHWAYS ,WT| Genetic studies of the aetiology of human metabolic disease: morbid obesity, obesity, severe insulin resistance and type 2 diabetes. ,EC| HYPERGENES ,NIH| ATN 004: HEALTHY CHOICES: MOTIVATIONAL ENHANCEMENT TO PROMOTE HEALTH AND REDU ,NIH| Epidemiology of IGF's and Aging ,EC| GEFOS ,AKA| The relation of diet, metabolism and genetic factors to obesity, abdominal obesity and weight gain: An epidemiological approach ,NIH| DYNAMICS OF HEALTH .AGING . AND BODY COMPOSITION /Pittsburgh/-260962101 ,MZOS| Determinants of health and disease in general and isolated human populationsAuthors: Tuomas O. Kilpeläinen; M. Carola Zillikens; Alena Stančáková; Francis M. Finucane; +113 AuthorsTuomas O. Kilpeläinen; M. Carola Zillikens; Alena Stančáková; Francis M. Finucane; Janina S. Ried; Claudia Langenberg; Weihua Zhang; Jacques S. Beckmann; Jian'an Luan; Liesbeth Vandenput; Unnur Styrkarsdottir; Yanhua Zhou; Albert V. Smith; Jing Hua Zhao; Najaf Amin; Sailaja Vedantam; So-Youn Shin; Talin Haritunians; Mao Fu; Mary F. Feitosa; Meena Kumari; Bjarni V. Halldorsson; Emmi Tikkanen; Massimo Mangino; Caroline Hayward; Ci Song; Alice M. Arnold; Yurii S. Aulchenko; Ben A. Oostra; Harry Campbell; L. Adrienne Cupples; Kathryn Davis; Angela Döring; Gudny Eiriksdottir; Karol Estrada; José Manuel Fernández-Real; Melissa Garcia; Christian Gieger; Nicole L. Glazer; Candace Guiducci; Albert Hofman; Steve E. Humphries; Bo Isomaa; Leonie C. Jacobs; Antti Jula; David Karasik; Magnus Karlsson; Kay-Tee Khaw; Lauren J. Kim; Mika Kivimäki; Norman Klopp; Brigitte Kühnel; Johanna Kuusisto; Yongmei Liu; Östen Ljunggren; Mattias Lorentzon; Robert Luben; Barbara McKnight; Dan Mellström; Braxton D. Mitchell; Vincent Mooser; José María Moreno; Satu Männistö; Jeffery R. O'Connell; Laura Pascoe; Leena Peltonen; Belén Peral; Markus Perola; Bruce M. Psaty; Veikko Salomaa; David B. Savage; Robert K. Semple; Tatjana Škarić-Jurić; Gunnar Sigurdsson; Kijoung Song; Tim D. Spector; Ann-Christine Syvänen; Philippa J. Talmud; Gudmar Thorleifsson; Unnur Thorsteinsdottir; André G. Uitterlinden; Cornelia M. van Duijn; Antonio Vidal-Puig; Sarah H. Wild; Alan F. Wright; Deborah J. Clegg; Eric E. Schadt; James F. Wilson; Igor Rudan; Samuli Ripatti; Ingrid B. Borecki; Alan R. Shuldiner; Erik Ingelsson; John-Olov Jansson; Robert C. Kaplan; Vilmundur Gudnason; Tamara B. Harris; Leif Groop; Douglas P. Kiel; Fernando Rivadeneira; Mark Walker; Inês Barroso; Peter Vollenweider; Gérard Waeber; John C. Chambers; Jaspal S. Kooner; Nicole Soranzo; Joel N. Hirschhorn; Kari Stefansson; H-Erich Wichmann; Claes Ohlsson; Stephen O'Rahilly; Nicholas J. Wareham; Elizabeth K. Speliotes; Caroline S. Fox; Markku Laakso; Ruth J. F. Loos;Finnish Diabetes Foundation; Finnish Diabetes Research Foundation; Finnish Foundation for Cardiovascular Research; Finnish Heart Foundation; Finnish Medical Society; Folkhälsan Research Foundation; Food Standards Agency (UK); Foundation for Life and Health in Finland; German Bündesministerium für Forschung und Technology (01AK803A-H and 01IG07015G); German Federal Ministry of Education and Research; German National Genome Research Network (NGFN-2 and NGFNPlus: 01GS0823); Giorgi-Cavaglieri Foundation; GlaxoSmithKline; Göteborg Medical Society; Gyllenberg Foundation; Health and Safety Executive (UK); Health Care Centers in Vasa, Närpes and Korsholm; Hjartavernd (the Icelandic Heart Association); John D. and Catherine T. MacArthur Foundation; Knut and Alice Wallenberg Foundation; Leenaards Foundation; Ludwig-Maximilians Universität München; Lundberg Foundation; Medical Research Council (UK); Men’s Associates of Hebrew SeniorLife; Ministerio de Ciencia e Innovación (Spain) (SAF-2009 and SAF-2008-02073); Ministry for Health, Welfare and Sports (The Netherlands); Ministry of Education (Finland); Ministry of Education, Culture and Science (The Netherlands); Municipal Health Care Center and Hospital in Jakobstad; Municipality of Rotterdam; Närpes Health Care Foundation; National Institute for Health Research (UK); US National Institutes of Health (USA) (AG13196, DK063491, K23-DK080145, M01-RR00425, N01-AG12100, N01-AG62101, N01-AG62103, N01-AG62106, N01-HC15103, N01-HC25195, N01-HC35129, N01-HC45133, N01-HC55222, N01-HC75150, N01- HC85079 through N01-HC85086, P30-DK072488, R01-AG031890-01, R01-AG18728, R01-AG032098-01A1, R01-AR/AG41398, R01-AR046838, R01-DK06833603, R01-DK075787, R01-DK07568102, R01-HL036310-20A2, R01-HL087652, R01-HL08770003, R01-HL088119, U01-HL080295, U01-HL72515 and U01-HL84756); Netherlands Genomics Initiative/Netherlands Consortium for Healthy Aging (050-060-810); Netherlands Organisation for Scientific Research (175.010.2005.011 and 911-03-012); Netherlands Organization for the Health Research and Development; Nordic Center of Excellence in Disease Genetics; Novo Nordisk Foundation; Ollqvist Foundation; Paavo Nurmi Foundation; Perklén Foundation; Petrus and Augusta Hedlunds Foundation; Research Institute for Diseases in the Elderly (014-93-015; RIDE2); Robert Dawson Evans Endowment; Royal Society (UK); Sahlgrenska Center for Cardiovascular and Metabolic Research (A305:188); Sahlgrenska University Hospital Foundation (ALF/LUA); Science Funding programme (UK); Scottish Executive Health Department; Sigrid Juselius Foundation; State of Bavaria; Stroke Association (UK); Swedish Cultural Foundation in Finland; Swedish Foundation for Strategic Research; Swedish Research Council (K2010-54X-09894-19-3, K2010-52X-20229-05-3 and 2006-3832); Swedish Strategic Foundation; Swiss Institute of Bioinformatics; Swiss National Science Foundation (3100AO-116323/1, 310000-112552 and 33CSCO-122661); TEKES (1510/31/06); Torsten and Ragnar Söderberg’s Foundation; United Kingdom NIHR Cambridge Biomedical Research Centre; University of Lausanne; University of Maryland General Clinical Research Center (M01 RR 16500); Uppsala University; Västra Götaland Foundation; and Wellcome Trust (077016/Z/05/Z, 084723/Z/08/Z and 091746/Z/10/Z). Funding was provided by Academy of Finland (10404, 124243, 129680, 129494, 141005 and 213506); Agency for Health Care Policy Research (HS06516); Althingi (the Icelandic Parliament); American Heart Association (10SDG269004); AstraZeneca; Baltimore Geriatric Research Education and Clinical Centers; Biocentrum Helsinki Foundation; Biotechnology and Biological Sciences Research Council (G20234); British Heart Foundation (PG/07/133/24260, RG/08/008, SP/04/002, SP/07/007/23671); CamStrad; Cancer Research UK; Cedars-Sinai Board of Governors’ Chair in Medical Genetics; Centre for Medical Systems Biology (The Netherlands); Centre Hospitalier Universitaire Vaudois (Lausanne); Croatian Ministry of Science, Education and Sport (196-1962766-2747, 216-1080315-0302 and 309-0061194-2023); Department of Health (UK); Department of Veterans Affairs (USA); Emil and Vera Cornell Foundation; Erasmus Medical Center (Rotterdam); Erasmus University (Rotterdam); European Commission (DG XII, FP7/2007-2013, FP7-KBBE-2010-4-266408, HEALTH-F2-2007-201681, HEALTH-F2-2008-201865-GEFOS, HEALTH-F4-2007-201413, HEALTH-F4-2007-201550, LSHG-CT-2006-018947, LSHG-CT-2006-01947, LSHM-CT-2003-503041, LSHM-CT-2004-512013, QLG1-CT-2001-01252 and QLG2-CT-2002-01254) Genome-wide association studies have identified 32 loci influencing body mass index, but this measure does not distinguish lean from fat mass. To identify adiposity loci, we meta-analyzed associations between ~2.5 million SNPs and body fat percentage from 36,626 individuals and followed up the 14 most significant (P < 10−6) independent loci in 39,576 individuals. We confirmed a previously established adiposity locus in FTO (P = 3 × 10−26) and identified two new loci associated with body fat percentage, one near IRS1 (P = 4 × 10−11) and one near SPRY2 (P = 3 × 10−8). Both loci contain genes with potential links to adipocyte physiology. Notably, the body-fat–decreasing allele near IRS1 is associated with decreased IRS1 expression and with an impaired metabolic profile, including an increased visceral to subcutaneous fat ratio, insulin resistance, dyslipidemia, risk of diabetes and coronary artery disease and decreased adiponectin levels. Our findings provide new insights into adiposity and insulin resistance. El pdf del artículo es el manuscrito de autor: PMC3262230.-- et al. Peer reviewed
Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2011 . Peer-reviewedCroatian Scientific Bibliography - CROSBIArticle . 2011Data sources: Croatian Scientific Bibliography - CROSBIadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/ng.866&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 300 citations 300 popularity Top 1% influence Top 1% impulse Top 1% Powered by BIP!visibility 23visibility views 23 download downloads 45 Powered bymore_vert Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2011 . Peer-reviewedCroatian Scientific Bibliography - CROSBIArticle . 2011Data sources: Croatian Scientific Bibliography - CROSBIadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/ng.866&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu