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description Publicationkeyboard_double_arrow_right Article , Other literature type 2015 Netherlands, SwitzerlandPublisher:Environmental Health Perspectives Funded by:SNSF | SAPALDIA COHORT STUDY: Mo..., SNSF | The SAPALDIA II Cohort St..., SNSF | Swiss Study on Air Pollut... +9 projectsSNSF| SAPALDIA COHORT STUDY: Mortality follow-up, maintenance of the cohort, the biobanks and the data bases. ,SNSF| The SAPALDIA II Cohort Study:Impact of environmental and personalrisk factors on the occurrence, course, remission and progressionof respiratory diseases in the Swiss population. ,SNSF| Swiss Study on Air Pollution and Lung Diseases in Adults: Participants'Follow-up and Further Analysis. ,SNSF| The SAPALDIA II Cohort Study:Impact of environmental and personalrisk factors on the occurrence, course, remission and progressionof respiratory diseases in the Swiss population. ,SNSF| SAPALDIA COHORT STUDY: Impact of air pollution on the cardiovascular and respiratory system in the Swiss population ,SNSF| Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) ,EC| ESCAPE ,SNSF| Swiss Study on Air Pollution and Lung Diseases in Adults: Mortality follow-up extension. ,SNSF| SAPALDIA COHORT STUDY: Impact of environmental and personal risk factors on the occurrence, course, remission and progression of respiratory disease in the swiss population-data analysis ,SNSF| Swiss study on air pollution and lung diseases in adults (SAPALDIA study) ,AKA| Climate change, air quality and housing - future challenges to public health / Consortium: CLAIH ,SNSF| Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA)Lanki, Timo; Hampel, Regina; Tiittanen, Pekka; Andrich, Silke; Beelen, Rob; Brunekreef, Bert; Dratva, Julia; De Faire, Ulf; Fuks, Kateryna B; Hoffmann, Barbara; Imboden, Medea; Jousilahti, Pekka; Koenig, Wolfgang; Mahabadi, Amir A; Künzli, Nino; Pedersen, Nancy L; Penell, Johanna; Pershagen, Göran; Probst-Hensch, Nicole M; Schaffner, Emmanuel; Schindler, Christian; Sugiri, Dorothea; Swart, Wim J R; Tsai, Ming-Yi; Turunen, Anu W; Weinmayr, Gudrun; Wolf, Kathrin; Yli-Tuomi, Tarja; Peters, Annette; IRAS RATIA2; LS IRAS EEPI ME (Milieu epidemiologie); Dep IRAS; Risk Assessment of Toxic and Immunomodulatory Agents;Background: Exposure to particulate matter air pollution (PM) has been associated with cardiovascular diseases. Objectives: In this study we evaluated whether annual exposure to ambient air pollution is associated with systemic inflammation, which is hypothesized to be an intermediate step to cardiovascular disease. Methods: Six cohorts of adults from Central and Northern Europe were used in this crosssectional study as part of the larger ESCAPE project (European Study of Cohorts for Air Pollution Effects). Data on levels of blood markers for systemic inflammation—high-sensitivity C-reactive protein (CRP) and fibrinogen—were available for 22,561 and 17,428 persons, respectively. Land use regression models were used to estimate cohort participants’ long-term exposure to various size fractions of PM, soot, and nitrogen oxides (NOx). In addition, traffic intensity on the closest street and traffic load within 100 m from home were used as indicators of traffic air pollution exposure. Results: Particulate air pollution was not associated with systemic inflammation. However, cohort participants living on a busy (> 10,000 vehicles/day) road had elevated CRP values (10.2%; 95% CI: 2.4, 18.8%, compared with persons living on a quiet residential street with < 1,000 vehicles/day). Annual NOx concentration was also positively associated with levels of CRP (3.2%; 95% CI: 0.3, 6.1 per 20 μg/m3), but the effect estimate was more sensitive to model adjustments. For fibrinogen, no consistent associations were observed. Conclusions: Living close to busy traffic was associated with increased CRP concentrations, a known risk factor for cardiovascular diseases. However, it remains unclear which specific air pollutants are responsible for the association. OA gold
NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2015Europe PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4529004Data sources: PubMed CentralEnvironmental Health Perspectives; Universitätsbibliographie, Universität Duisburg-EssenArticle . 2015 . Peer-reviewedUniversitätsbibliographie, Universität Duisburg-EssenArticle . 2015Data sources: Universitätsbibliographie, Universität Duisburg-Essenadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 75 citations 75 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2015Europe PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4529004Data sources: PubMed CentralEnvironmental Health Perspectives; Universitätsbibliographie, Universität Duisburg-EssenArticle . 2015 . Peer-reviewedUniversitätsbibliographie, Universität Duisburg-EssenArticle . 2015Data sources: Universitätsbibliographie, Universität Duisburg-Essenadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1289/ehp.1408224&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2015 Norway, Switzerland, Netherlands, Denmark, Germany, Italy, Italy, Denmark, AustraliaPublisher:Environmental Health Perspectives Funded by:SNSF | SAPALDIA COHORT STUDY: Mo..., SNSF | The SAPALDIA II Cohort St..., SNSF | Swiss Study on Air Pollut... +11 projectsSNSF| SAPALDIA COHORT STUDY: Mortality follow-up, maintenance of the cohort, the biobanks and the data bases. ,SNSF| The SAPALDIA II Cohort Study:Impact of environmental and personalrisk factors on the occurrence, course, remission and progressionof respiratory diseases in the Swiss population. ,SNSF| Swiss Study on Air Pollution and Lung Diseases in Adults: Participants'Follow-up and Further Analysis. ,SNSF| The SAPALDIA II Cohort Study:Impact of environmental and personalrisk factors on the occurrence, course, remission and progressionof respiratory diseases in the Swiss population. ,SNSF| SAPALDIA COHORT STUDY: Impact of air pollution on the cardiovascular and respiratory system in the Swiss population ,SNSF| Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) ,SNSF| Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) ,EC| ESCAPE ,NIH| Interstitial Cystitis in Swedish Twins ,AKA| Climate change, air quality and housing - future challenges to public health / Consortium: CLAIH ,SNSF| SAPALDIA COHORT STUDY: Impact of environmental and personal risk factors on the occurrence, course, remission and progression of respiratory disease in the swiss population-data analysis ,SNSF| Swiss study on air pollution and lung diseases in adults (SAPALDIA study) ,SNSF| Swiss Study on Air Pollution and Lung Diseases in Adults: Mortality follow-up extension. ,NIH| DEMENTIA IN SWEDISH TWINSRob Beelen; Gerard Hoek; Ole Raaschou-Nielsen; Massimo Stafoggia; Zorana Jovanovic Andersen; Gudrun Weinmayr; Barbara Hoffmann; Kathrin Wolf; Evangelia Samoli; Paul Fischer; Mark J. Nieuwenhuijsen; Wei W. Xun; Klea Katsouyanni; Konstantina Dimakopoulou; Alessandro Marcon; Erkki Vartiainen; Timo Lanki; Tarja Yli-Tuomi; Bente Oftedal; Per E. Schwarze; Per Nafstad; Ulf de Faire; Nancy L. Pedersen; Claes-Göran Östenson; Laura Fratiglioni; Johanna Penell; Michal Korek; Göran Pershagen; Kirsten Thorup Eriksen; Kim Overvad; Mette Sørensen; Marloes Eeftens; Petra H.M. Peeters; Kees Meliefste; Meng Wang; Bas Bueno-de-Mesquita; Dorothea Sugiri; Ursula Krämer; Joachim Heinrich; Kees de Hoogh; Timothy J. Key; Annette Peters; Regina Hampel; Hans Concin; Gabriele Nagel; Andrea Jaensch; Alex Ineichen; Ming-Yi Tsai; Emmanuel Schaffner; Nicole Probst-Hensch; Christian Schindler; Martina S. Ragettli; Alice Vilier; Françoise Clavel-Chapelon; Christophe Declercq; Fulvio Ricceri; Carlotta Sacerdote; C Galassi; Enrica Migliore; Andrea Ranzi; Giulia Cesaroni; Chiara Badaloni; Francesco Forastiere; Michail Katsoulis; Antonia Trichopoulou; Menno Keuken; Aleksandra Jedynska; Ingeborg M. Kooter; Jaakko Kukkonen; Ranjeet S. Sokhi; Paolo Vineis; Bert Brunekreef;pmc: PMC4455583
pmid: 25712504
handle: 1874/332230 , 11250/296481 , 1874/326554 , 2318/1508365 , 11562/955514
pmc: PMC4455583
pmid: 25712504
handle: 1874/332230 , 11250/296481 , 1874/326554 , 2318/1508365 , 11562/955514
Background Studies have shown associations between mortality and long-term exposure to particulate matter air pollution. Few cohort studies have estimated the effects of the elemental composition of particulate matter on mortality. Objectives Our aim was to study the association between natural-cause mortality and long-term exposure to elemental components of particulate matter. Methods Mortality and confounder data from 19 European cohort studies were used. Residential exposure to eight a priori–selected components of particulate matter (PM) was characterized following a strictly standardized protocol. Annual average concentrations of copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc within PM size fractions ≤ 2.5 μm (PM2.5) and ≤ 10 μm (PM10) were estimated using land-use regression models. Cohort-specific statistical analyses of the associations between mortality and air pollution were conducted using Cox proportional hazards models using a common protocol followed by meta-analysis. Results The total study population consisted of 291,816 participants, of whom 25,466 died from a natural cause during follow-up (average time of follow-up, 14.3 years). Hazard ratios were positive for almost all elements and statistically significant for PM2.5 sulfur (1.14; 95% CI: 1.06, 1.23 per 200 ng/m3). In a two-pollutant model, the association with PM2.5 sulfur was robust to adjustment for PM2.5 mass, whereas the association with PM2.5 mass was reduced. Conclusions Long-term exposure to PM2.5 sulfur was associated with natural-cause mortality. This association was robust to adjustment for other pollutants and PM2.5. Citation Beelen R, Hoek G, Raaschou-Nielsen O, Stafoggia M, Andersen ZJ, Weinmayr G, Hoffmann B, Wolf K, Samoli E, Fischer PH, Nieuwenhuijsen MJ, Xun WW, Katsouyanni K, Dimakopoulou K, Marcon A, Vartiainen E, Lanki T, Yli-Tuomi T, Oftedal B, Schwarze PE, Nafstad P, De Faire U, Pedersen NL, Östenson C-G, Fratiglioni L, Penell J, Korek M, Pershagen G, Eriksen KT, Overvad K, Sørensen M, Eeftens M, Peeters PH, Meliefste K, Wang M, Bueno-de-Mesquita HB, Sugiri D, Krämer U, Heinrich J, de Hoogh K, Key T, Peters A, Hampel R, Concin H, Nagel G, Jaensch A, Ineichen A, Tsai MY, Schaffner E, Probst-Hensch NM, Schindler C, Ragettli MS, Vilier A, Clavel-Chapelon F, Declercq C, Ricceri F, Sacerdote C, Galassi C, Migliore E, Ranzi A, Cesaroni G, Badaloni C, Forastiere F, Katsoulis M, Trichopoulou A, Keuken M, Jedynska A, Kooter IM, Kukkonen J, Sokhi RS, Vineis P, Brunekreef B. 2015. Natural-cause mortality and long-term exposure to particle components: an analysis of 19 European cohorts within the Multi-Center ESCAPE Project. Environ Health Perspect 123:525–533; http://dx.doi.org/10.1289/ehp.1408095
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4455583Data sources: PubMed CentralNARCIS; Utrecht University RepositoryArticle . 2015Publication Server of Helmholtz Zentrum München (PuSH)Article . 2015Data sources: Publication Server of Helmholtz Zentrum München (PuSH)VBN; Aalborg University Research PortalArticle . 2015IRIS - Università degli Studi di VeronaArticle . 2015Data sources: IRIS - Università degli Studi di Veronaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1289/ehp.1408095&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 156 citations 156 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4455583Data sources: PubMed CentralNARCIS; Utrecht University RepositoryArticle . 2015Publication Server of Helmholtz Zentrum München (PuSH)Article . 2015Data sources: Publication Server of Helmholtz Zentrum München (PuSH)VBN; Aalborg University Research PortalArticle . 2015IRIS - Università degli Studi di VeronaArticle . 2015Data sources: IRIS - Università degli Studi di Veronaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1289/ehp.1408095&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Article , Other literature type 2015 Netherlands, SwitzerlandPublisher:Environmental Health Perspectives Funded by:SNSF | SAPALDIA COHORT STUDY: Mo..., SNSF | The SAPALDIA II Cohort St..., SNSF | Swiss Study on Air Pollut... +9 projectsSNSF| SAPALDIA COHORT STUDY: Mortality follow-up, maintenance of the cohort, the biobanks and the data bases. ,SNSF| The SAPALDIA II Cohort Study:Impact of environmental and personalrisk factors on the occurrence, course, remission and progressionof respiratory diseases in the Swiss population. ,SNSF| Swiss Study on Air Pollution and Lung Diseases in Adults: Participants'Follow-up and Further Analysis. ,SNSF| The SAPALDIA II Cohort Study:Impact of environmental and personalrisk factors on the occurrence, course, remission and progressionof respiratory diseases in the Swiss population. ,SNSF| SAPALDIA COHORT STUDY: Impact of air pollution on the cardiovascular and respiratory system in the Swiss population ,SNSF| Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) ,EC| ESCAPE ,SNSF| Swiss Study on Air Pollution and Lung Diseases in Adults: Mortality follow-up extension. ,SNSF| SAPALDIA COHORT STUDY: Impact of environmental and personal risk factors on the occurrence, course, remission and progression of respiratory disease in the swiss population-data analysis ,SNSF| Swiss study on air pollution and lung diseases in adults (SAPALDIA study) ,AKA| Climate change, air quality and housing - future challenges to public health / Consortium: CLAIH ,SNSF| Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA)Lanki, Timo; Hampel, Regina; Tiittanen, Pekka; Andrich, Silke; Beelen, Rob; Brunekreef, Bert; Dratva, Julia; De Faire, Ulf; Fuks, Kateryna B; Hoffmann, Barbara; Imboden, Medea; Jousilahti, Pekka; Koenig, Wolfgang; Mahabadi, Amir A; Künzli, Nino; Pedersen, Nancy L; Penell, Johanna; Pershagen, Göran; Probst-Hensch, Nicole M; Schaffner, Emmanuel; Schindler, Christian; Sugiri, Dorothea; Swart, Wim J R; Tsai, Ming-Yi; Turunen, Anu W; Weinmayr, Gudrun; Wolf, Kathrin; Yli-Tuomi, Tarja; Peters, Annette; IRAS RATIA2; LS IRAS EEPI ME (Milieu epidemiologie); Dep IRAS; Risk Assessment of Toxic and Immunomodulatory Agents;Background: Exposure to particulate matter air pollution (PM) has been associated with cardiovascular diseases. Objectives: In this study we evaluated whether annual exposure to ambient air pollution is associated with systemic inflammation, which is hypothesized to be an intermediate step to cardiovascular disease. Methods: Six cohorts of adults from Central and Northern Europe were used in this crosssectional study as part of the larger ESCAPE project (European Study of Cohorts for Air Pollution Effects). Data on levels of blood markers for systemic inflammation—high-sensitivity C-reactive protein (CRP) and fibrinogen—were available for 22,561 and 17,428 persons, respectively. Land use regression models were used to estimate cohort participants’ long-term exposure to various size fractions of PM, soot, and nitrogen oxides (NOx). In addition, traffic intensity on the closest street and traffic load within 100 m from home were used as indicators of traffic air pollution exposure. Results: Particulate air pollution was not associated with systemic inflammation. However, cohort participants living on a busy (> 10,000 vehicles/day) road had elevated CRP values (10.2%; 95% CI: 2.4, 18.8%, compared with persons living on a quiet residential street with < 1,000 vehicles/day). Annual NOx concentration was also positively associated with levels of CRP (3.2%; 95% CI: 0.3, 6.1 per 20 μg/m3), but the effect estimate was more sensitive to model adjustments. For fibrinogen, no consistent associations were observed. Conclusions: Living close to busy traffic was associated with increased CRP concentrations, a known risk factor for cardiovascular diseases. However, it remains unclear which specific air pollutants are responsible for the association. OA gold
NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2015Europe PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4529004Data sources: PubMed CentralEnvironmental Health Perspectives; Universitätsbibliographie, Universität Duisburg-EssenArticle . 2015 . Peer-reviewedUniversitätsbibliographie, Universität Duisburg-EssenArticle . 2015Data sources: Universitätsbibliographie, Universität Duisburg-Essenadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1289/ehp.1408224&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 75 citations 75 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2015Europe PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4529004Data sources: PubMed CentralEnvironmental Health Perspectives; Universitätsbibliographie, Universität Duisburg-EssenArticle . 2015 . Peer-reviewedUniversitätsbibliographie, Universität Duisburg-EssenArticle . 2015Data sources: Universitätsbibliographie, Universität Duisburg-Essenadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1289/ehp.1408224&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2015 Norway, Switzerland, Netherlands, Denmark, Germany, Italy, Italy, Denmark, AustraliaPublisher:Environmental Health Perspectives Funded by:SNSF | SAPALDIA COHORT STUDY: Mo..., SNSF | The SAPALDIA II Cohort St..., SNSF | Swiss Study on Air Pollut... +11 projectsSNSF| SAPALDIA COHORT STUDY: Mortality follow-up, maintenance of the cohort, the biobanks and the data bases. ,SNSF| The SAPALDIA II Cohort Study:Impact of environmental and personalrisk factors on the occurrence, course, remission and progressionof respiratory diseases in the Swiss population. ,SNSF| Swiss Study on Air Pollution and Lung Diseases in Adults: Participants'Follow-up and Further Analysis. ,SNSF| The SAPALDIA II Cohort Study:Impact of environmental and personalrisk factors on the occurrence, course, remission and progressionof respiratory diseases in the Swiss population. ,SNSF| SAPALDIA COHORT STUDY: Impact of air pollution on the cardiovascular and respiratory system in the Swiss population ,SNSF| Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) ,SNSF| Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) ,EC| ESCAPE ,NIH| Interstitial Cystitis in Swedish Twins ,AKA| Climate change, air quality and housing - future challenges to public health / Consortium: CLAIH ,SNSF| SAPALDIA COHORT STUDY: Impact of environmental and personal risk factors on the occurrence, course, remission and progression of respiratory disease in the swiss population-data analysis ,SNSF| Swiss study on air pollution and lung diseases in adults (SAPALDIA study) ,SNSF| Swiss Study on Air Pollution and Lung Diseases in Adults: Mortality follow-up extension. ,NIH| DEMENTIA IN SWEDISH TWINSRob Beelen; Gerard Hoek; Ole Raaschou-Nielsen; Massimo Stafoggia; Zorana Jovanovic Andersen; Gudrun Weinmayr; Barbara Hoffmann; Kathrin Wolf; Evangelia Samoli; Paul Fischer; Mark J. Nieuwenhuijsen; Wei W. Xun; Klea Katsouyanni; Konstantina Dimakopoulou; Alessandro Marcon; Erkki Vartiainen; Timo Lanki; Tarja Yli-Tuomi; Bente Oftedal; Per E. Schwarze; Per Nafstad; Ulf de Faire; Nancy L. Pedersen; Claes-Göran Östenson; Laura Fratiglioni; Johanna Penell; Michal Korek; Göran Pershagen; Kirsten Thorup Eriksen; Kim Overvad; Mette Sørensen; Marloes Eeftens; Petra H.M. Peeters; Kees Meliefste; Meng Wang; Bas Bueno-de-Mesquita; Dorothea Sugiri; Ursula Krämer; Joachim Heinrich; Kees de Hoogh; Timothy J. Key; Annette Peters; Regina Hampel; Hans Concin; Gabriele Nagel; Andrea Jaensch; Alex Ineichen; Ming-Yi Tsai; Emmanuel Schaffner; Nicole Probst-Hensch; Christian Schindler; Martina S. Ragettli; Alice Vilier; Françoise Clavel-Chapelon; Christophe Declercq; Fulvio Ricceri; Carlotta Sacerdote; C Galassi; Enrica Migliore; Andrea Ranzi; Giulia Cesaroni; Chiara Badaloni; Francesco Forastiere; Michail Katsoulis; Antonia Trichopoulou; Menno Keuken; Aleksandra Jedynska; Ingeborg M. Kooter; Jaakko Kukkonen; Ranjeet S. Sokhi; Paolo Vineis; Bert Brunekreef;pmc: PMC4455583
pmid: 25712504
handle: 1874/332230 , 11250/296481 , 1874/326554 , 2318/1508365 , 11562/955514
pmc: PMC4455583
pmid: 25712504
handle: 1874/332230 , 11250/296481 , 1874/326554 , 2318/1508365 , 11562/955514
Background Studies have shown associations between mortality and long-term exposure to particulate matter air pollution. Few cohort studies have estimated the effects of the elemental composition of particulate matter on mortality. Objectives Our aim was to study the association between natural-cause mortality and long-term exposure to elemental components of particulate matter. Methods Mortality and confounder data from 19 European cohort studies were used. Residential exposure to eight a priori–selected components of particulate matter (PM) was characterized following a strictly standardized protocol. Annual average concentrations of copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc within PM size fractions ≤ 2.5 μm (PM2.5) and ≤ 10 μm (PM10) were estimated using land-use regression models. Cohort-specific statistical analyses of the associations between mortality and air pollution were conducted using Cox proportional hazards models using a common protocol followed by meta-analysis. Results The total study population consisted of 291,816 participants, of whom 25,466 died from a natural cause during follow-up (average time of follow-up, 14.3 years). Hazard ratios were positive for almost all elements and statistically significant for PM2.5 sulfur (1.14; 95% CI: 1.06, 1.23 per 200 ng/m3). In a two-pollutant model, the association with PM2.5 sulfur was robust to adjustment for PM2.5 mass, whereas the association with PM2.5 mass was reduced. Conclusions Long-term exposure to PM2.5 sulfur was associated with natural-cause mortality. This association was robust to adjustment for other pollutants and PM2.5. Citation Beelen R, Hoek G, Raaschou-Nielsen O, Stafoggia M, Andersen ZJ, Weinmayr G, Hoffmann B, Wolf K, Samoli E, Fischer PH, Nieuwenhuijsen MJ, Xun WW, Katsouyanni K, Dimakopoulou K, Marcon A, Vartiainen E, Lanki T, Yli-Tuomi T, Oftedal B, Schwarze PE, Nafstad P, De Faire U, Pedersen NL, Östenson C-G, Fratiglioni L, Penell J, Korek M, Pershagen G, Eriksen KT, Overvad K, Sørensen M, Eeftens M, Peeters PH, Meliefste K, Wang M, Bueno-de-Mesquita HB, Sugiri D, Krämer U, Heinrich J, de Hoogh K, Key T, Peters A, Hampel R, Concin H, Nagel G, Jaensch A, Ineichen A, Tsai MY, Schaffner E, Probst-Hensch NM, Schindler C, Ragettli MS, Vilier A, Clavel-Chapelon F, Declercq C, Ricceri F, Sacerdote C, Galassi C, Migliore E, Ranzi A, Cesaroni G, Badaloni C, Forastiere F, Katsoulis M, Trichopoulou A, Keuken M, Jedynska A, Kooter IM, Kukkonen J, Sokhi RS, Vineis P, Brunekreef B. 2015. Natural-cause mortality and long-term exposure to particle components: an analysis of 19 European cohorts within the Multi-Center ESCAPE Project. Environ Health Perspect 123:525–533; http://dx.doi.org/10.1289/ehp.1408095
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4455583Data sources: PubMed CentralNARCIS; Utrecht University RepositoryArticle . 2015Publication Server of Helmholtz Zentrum München (PuSH)Article . 2015Data sources: Publication Server of Helmholtz Zentrum München (PuSH)VBN; Aalborg University Research PortalArticle . 2015IRIS - Università degli Studi di VeronaArticle . 2015Data sources: IRIS - Università degli Studi di Veronaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1289/ehp.1408095&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 156 citations 156 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4455583Data sources: PubMed CentralNARCIS; Utrecht University RepositoryArticle . 2015Publication Server of Helmholtz Zentrum München (PuSH)Article . 2015Data sources: Publication Server of Helmholtz Zentrum München (PuSH)VBN; Aalborg University Research PortalArticle . 2015IRIS - Università degli Studi di VeronaArticle . 2015Data sources: IRIS - Università degli Studi di Veronaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1289/ehp.1408095&type=result"></script>'); --> </script>
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