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description Publicationkeyboard_double_arrow_right Article 2022 Australia, United Kingdom, Spain, NorwayPublisher:Springer Science and Business Media LLC Funded by:EC | ENRIECO, EC | ESCAPE, EC | ATHLETE +1 projectsEC| ENRIECO ,EC| ESCAPE ,EC| ATHLETE ,EC| HELIXLéa Maitre; Mariona Bustamante; Carles Hernández-Ferrer; Denise Thiel; Chung-Ho E. Lau; Alexandros P. Siskos; Marta Vives-Usano; Carlos Ruiz-Arenas; Dolors Pelegrí-Sisó; Oliver Robinson; Dan Mason; John Wright; Solène Cadiou; Rémy Slama; Barbara Heude; Maribel Casas; Jordi Sunyer; Eleni Z. Papadopoulou; Kristine B. Gutzkow; Sandra Andrusaityte; Regina Grazuleviciene; Marina Vafeiadi; Leda Chatzi; Amrit K. Sakhi; Cathrine Thomsen; Ibon Tamayo; Mark Nieuwenhuijsen; Jose Urquiza; Eva Borràs; Eduard Sabidó; Inés Quintela; Ángel Carracedo; Xavier Estivill; Muireann Coen; Juan R. González; Hector C. Keun; Martine Vrijheid;We would like to thank all the families for their generous contribution. The study has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 874583 (ATHLETE project). Data were collected as part of the European Community’s Seventh Framework Programme (FP7/2007-206) under grant agreement no 308333 (HELIX project). BiB received core infrastructure funding from the Wellcome Trust (WT101597MA) and a joint grant from the UK Medical Research Council (MRC) and Economic and Social Science Research Council (ESRC) (MR/N024397/1). INMA data collections were supported by grants from the Instituto de Salud Carlos III, CIBERESP, and the Generalitat de Catalunya-CIRIT. KANC was funded by the grant of the Lithuanian Agency for Science Innovation and Technology (6-04-2014_31V-66). The Norwegian Mother, Father and Child Cohort Study is supported by the Norwegian Ministry of Health and Care Services and the Ministry of Education and Research. The Rhea project was financially supported by European projects (EU FP6-2003-Food-3-NewGeneris, EU FP6. STREP Hiwate, EU FP7 ENV.2007.1.2.2.2. Project No 211250 Escape, EU FP7-2008-ENV-1.2.1.4 Envirogenomarkers, EU FP7-HEALTH-2009- single stage CHICOS, EU FP7 ENV.2008.1.2.1.6. Proposal No 226285 ENRIECO, EU- FP7- HEALTH-2012 Proposal No 308333 HELIX), and the Greek Ministry of Health (Program of Prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece: 2011-2014; “Rhea Plus”: Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012-15). ISGlobal acknowledges support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. L.M. is funded by a Juan de la Cierva-Incorporación fellowship (IJC2018-035394-I) awarded by the Spanish Ministerio de Economía, Industria y Competitividad. M.V.-U. and C.R.-A. were supported by a FI fellowship from the Catalan Government (FI-DGR 2015 and #016FI_B 00272). M. Casas received funding from Instituto Carlos III (Ministry of Economy and Competitiveness) (CD12/00563 and MS16/00128). Environmental exposures during early life play a critical role in life-course health, yet the molecular phenotypes underlying environmental effects on health are poorly understood. In the Human Early Life Exposome (HELIX) project, a multi-centre cohort of 1301 mother-child pairs, we associate individual exposomes consisting of >100 chemical, outdoor, social and lifestyle exposures assessed in pregnancy and childhood, with multi-omics profiles (methylome, transcriptome, proteins and metabolites) in childhood. We identify 1170 associations, 249 in pregnancy and 921 in childhood, which reveal potential biological responses and sources of exposure. Pregnancy exposures, including maternal smoking, cadmium and molybdenum, are predominantly associated with child DNA methylation changes. In contrast, childhood exposures are associated with features across all omics layers, most frequently the serum metabolome, revealing signatures for diet, toxic chemical compounds, essential trace elements, and weather conditions, among others. Our comprehensive and unique resource of all associations ( https://helixomics.isglobal.org/ ) will serve to guide future investigation into the biological imprints of the early life exposome.
UPF Digital Reposito... arrow_drop_down UPF Digital Repository; Nature CommunicationsOther literature type . Article . 2022 . Peer-reviewedLicense: CC BYNorwegian Institute of Public Health Open RepositoryArticle . 2022Data sources: Norwegian Institute of Public Health Open RepositorySpiral - Imperial College Digital RepositoryArticle . 2022License: CC BYData sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 24 citations 24 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 6visibility views 6 download downloads 5 Powered bymore_vert UPF Digital Reposito... arrow_drop_down UPF Digital Repository; Nature CommunicationsOther literature type . Article . 2022 . Peer-reviewedLicense: CC BYNorwegian Institute of Public Health Open RepositoryArticle . 2022Data sources: Norwegian Institute of Public Health Open RepositorySpiral - Imperial College Digital RepositoryArticle . 2022License: CC BYData sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2021 Belgium, Switzerland, Norway, United Kingdom, France, SpainPublisher:Copernicus GmbH Funded by:SNSF | The role of Southern Ocea..., SNSF | Impact of interactions be..., EC | ERA-PLANET +3 projectsSNSF| The role of Southern Ocean stratification in future ocean CO2 and heat uptake ,SNSF| Impact of interactions between microorganisms on iron and carbon recycling in the Southern Ocean : consequences for iron limitation ,EC| ERA-PLANET ,SNSF| Natural Atmospheric new particle formation (NAPF) ,SNSF| Antarctic precipitation, snow accumulation processes, and ice-ocean interactions ,SNSF| The role of Southern Ocean stratification in future ocean CO2 and heat uptakeS. Landwehr; M. Volpi; F. A. Haumann; F. A. Haumann; C. M. Robinson; I. Thurnherr; I. Thurnherr; V. Ferracci; A. Baccarini; A. Baccarini; J. Thomas; I. Gorodetskaya; I. Gorodetskaya; C. Tatzelt; S. Henning; R. L. Modini; H. J. Forrer; H. J. Forrer; Y. Lin; Y. Lin; Y. Lin; N. Cassar; N. Cassar; R. Simó; C. Hassler; C. Hassler; A. Moallemi; S. E. Fawcett; N. Harris; R. Airs; M. H. Derkani; A. Alberello; A. Toffoli; G. Chen; P. Rodríguez-Ros; M. Zamanillo; P. Cortés-Greus; L. Xue; C. G. Bolas; K. C. Leonard; K. C. Leonard; F. Perez-Cruz; F. Perez-Cruz; D. Walton; J. Schmale;handle: 10261/258325 , 11250/2987421
The Southern Ocean is a critical component of Earth's climate system, but its remoteness makes it challenging to develop a holistic understanding of its processes from the small scale to the large scale. As a result, our knowledge of this vast region remains largely incomplete. The Antarctic Circumnavigation Expedition (ACE, austral summer 2016/2017) surveyed a large number of variables describing the state of the ocean and the atmosphere, the freshwater cycle, atmospheric chemistry, and ocean biogeochemistry and microbiology. This circumpolar cruise included visits to 12 remote islands, the marginal ice zone, and the Antarctic coast. Here, we use 111 of the observed variables to study the latitudinal gradients, seasonality, shorter-term variations, geographic setting of environmental processes, and interactions between them over the duration of 90 d. To reduce the dimensionality and complexity of the dataset and make the relations between variables interpretable we applied an unsupervised machine learning method, the sparse principal component analysis (sPCA), which describes environmental processes through 14 latent variables. To derive a robust statistical perspective on these processes and to estimate the uncertainty in the sPCA decomposition, we have developed a bootstrap approach. Our results provide a proof of concept that sPCA with uncertainty analysis is able to identify temporal patterns from diurnal to seasonal cycles, as well as geographical gradients and “hotspots” of interaction between environmental compartments. While confirming many well known processes, our analysis provides novel insights into the Southern Ocean water cycle (freshwater fluxes), trace gases (interplay between seasonality, sources, and sinks), and microbial communities (nutrient limitation and island mass effects at the largest scale ever reported). More specifically, we identify the important role of the oceanic circulations, frontal zones, and islands in shaping the nutrient availability that controls biological community composition and productivity; the fact that sea ice controls sea water salinity, dampens the wave field, and is associated with increased phytoplankton growth and net community productivity possibly due to iron fertilisation and reduced light limitation; and the clear regional patterns of aerosol characteristics that have emerged, stressing the role of the sea state, atmospheric chemical processing, and source processes near hotspots for the availability of cloud condensation nuclei and hence cloud formation. A set of key variables and their combinations, such as the difference between the air and sea surface temperature, atmospheric pressure, sea surface height, geostrophic currents, upper-ocean layer light intensity, surface wind speed and relative humidity played an important role in our analysis, highlighting the necessity for Earth system models to represent them adequately. In conclusion, our study highlights the use of sPCA to identify key ocean–atmosphere interactions across physical, chemical, and biological processes and their associated spatio-temporal scales. It thereby fills an important gap between simple correlation analyses and complex Earth system models. The sPCA processing code is available as open-access from the following link: https://renkulab.io/gitlab/ACE-ASAID/spca-decomposition (last access: 29 March 2021). As we show here, it can be used for an exploration of environmental data that is less prone to cognitive biases (and confirmation biases in particular) compared to traditional regression analysis that might be affected by the underlying research question 75 pages, 8 figures, 3 tables, 6 appendixes, supplement https://doi.org/10.5194/esd-12-1295-2021-supplement.-- Code and data availability: The python code that was used for the analysis and to create the plots is available at https://renkulab.io/gitlab/ACE-ASAID/spca-decomposition (last access: 29 March 2021; Volpi, 2021) and as a Renku project https://renkulab.io/projects/ACE-ASAID/spca-decomposition (last access: 29 March 2021; Volpi and Landwehr, 2021). For the availability of the data used in this study please refer to Tables B1 to B8 in Appendix B Rafel Simó, Marina Zamanillo, Pau Cortés-Greus, and Pablo Rodríguez-Ros were supported by the Spanish Ministry of Science through the BIOGAPS project (CTM2016-81008-R) With the institutional support of the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000928-S) Peer reviewed
Copernicus Publicati... arrow_drop_down Copernicus Publications; NERC Open Research ArchiveOther literature type . Article . 2021 . Peer-reviewedUniversity of East Anglia digital repositoryArticle . 2021 . Peer-reviewedData sources: University of East Anglia digital repositoryArchiMer - Institutional Archive of IfremerOther literature type . 2021Data sources: ArchiMer - Institutional Archive of IfremerArchiMer - Institutional Archive of IfremerOther literature type . 2021Data sources: ArchiMer - Institutional Archive of IfremerSpiral - Imperial College Digital RepositoryArticle . 2021License: CC BYData sources: Spiral - Imperial College Digital RepositoryRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021 . Peer-reviewedInfoscience - EPFL scientific publicationsArticleData sources: Infoscience - EPFL scientific publicationsBergen Open Research Archive - UiB; Norwegian Open Research ArchivesArticle . 2021 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 11 citations 11 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 50visibility views 50 download downloads 104 Powered bymore_vert Copernicus Publicati... arrow_drop_down Copernicus Publications; NERC Open Research ArchiveOther literature type . Article . 2021 . Peer-reviewedUniversity of East Anglia digital repositoryArticle . 2021 . Peer-reviewedData sources: University of East Anglia digital repositoryArchiMer - Institutional Archive of IfremerOther literature type . 2021Data sources: ArchiMer - Institutional Archive of IfremerArchiMer - Institutional Archive of IfremerOther literature type . 2021Data sources: ArchiMer - Institutional Archive of IfremerSpiral - Imperial College Digital RepositoryArticle . 2021License: CC BYData sources: Spiral - Imperial College Digital RepositoryRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021 . Peer-reviewedInfoscience - EPFL scientific publicationsArticleData sources: Infoscience - EPFL scientific publicationsBergen Open Research Archive - UiB; Norwegian Open Research ArchivesArticle . 2021 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 United Kingdom, Australia, SpainPublisher:Elsevier BV Funded by:EC | ESCAPE, EC | LIFECYCLE, UKRI | Metabolomic and omic asse... +4 projectsEC| ESCAPE ,EC| LIFECYCLE ,UKRI| Metabolomic and omic assessment of biological ageing across the life-course (METAGE) ,EC| ENRIECO ,WT| The Born in Bradford (BiB) Study an international biomedical resource for exploring genetic and early life determinants of health and development in a deprived multi-ethnic population. ,EC| HELIX ,EC| ATHLETEAuthors: Prado Bert, Paula de; Ruiz-Arenas, Carlos; Vives-Usano, Marta; Andrusaityte, Sandra; +22 AuthorsPrado Bert, Paula de; Ruiz-Arenas, Carlos; Vives-Usano, Marta; Andrusaityte, Sandra; Cadiou, Solène; Carracedo Álvarez, Ángel María; Casas, Maribel; Chatzi, Leda; Dadvand, Payam; González Ruiz, Juan Ramon; Grazuleviciene, Regina; Gutzkow, Kristine Bjerve; Haug, Line Småstuen; Hernandez Ferrer, Carles; Keun, Hector C.; Lepeule, Johanna; Maitre, Léa; McEachan, Rosemary; Nieuwenhuijsen, Mark J.; Pelegrí, Dolors; Robinson, Oliver; Slama, Rémy; Vafeiadi, Marina; Sunyer, Jordi; Vrijheid, Martine; Bustamante, Mariona;The study received funding from the European Community’s Seventh Framework Programme (FP7/2007-206) (grant agreement no 308333) (HELIX project), the H2020-EU.3.1.2. - Preventing Disease Programme (grant agreement no 874583) (ATHLETE project), and from the European Union’s Horizon 2020 research and innovation programme (grant Agreement number: 733206) (Early Life stressors and Lifecycle Health (LIFECYCLE)). BiB received funding from the Welcome Trust (WT101597MA), from the UK Medical Research Council (MRC) and Economic and Social Science Research Council (ESRC) (MR/N024397/1). INMA was supported by grants from the Instituto de Salud Carlos III, CIBERESP, and the Generalitat de Catalunya-CIRIT. KANC was funded by the grant of the Lithuanian Agency for Science Innovation and Technology (6-04-2014_31V-66). The Norwegian Mother, Father and Child Cohort Study is supported by the Norwegian Ministry of Health and Care Services and the Ministry of Education and Research. The Rhea project was financially supported by European projects (EU FP6-2003-Food-3-NewGeneris, EU FP6. STREP Hiwate, EU FP7 ENV.2007.1.2.2.2. Project No 211250 Escape, EU FP7-2008-ENV-1.2.1.4 Envirogenomarkers, EU FP7-HEALTH-2009- single stage CHICOS, EU FP7 ENV.2008.1.2.1.6. Proposal No 226285 ENRIECO, EU- FP7- HEALTH-2012 Proposal No 308333 HELIX), and the Greek Ministry of Health (Program of Prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece: 2011-2014; “Rhea Plus”: Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012-15). We acknowledge support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. OR was funded by a UKRI Future Leaders Fellowship (MR/S03532X/1). MV-U and CR-A were supported by a FI fellowship from the Catalan Government (FI-DGR 2015 and #016FI_B 00272). MC received funding from Instituto Carlos III (Ministry of Economy and Competitiveness) (CD12/00563 and MS16/00128) The early-life exposome influences future health and accelerated biological aging has been proposed as one of the underlying biological mechanisms. We investigated the association between more than 100 exposures assessed during pregnancy and in childhood (including indoor and outdoor air pollutants, built environment, green environments, tobacco smoking, lifestyle exposures, and biomarkers of chemical pollutants), and epigenetic age acceleration in 1,173 children aged 7 years old from the Human Early-Life Exposome project. Age acceleration was calculated based on Horvath’s Skin and Blood clock using child blood DNA methylation measured by Infinium HumanMethylation450 BeadChips. We performed an exposure-wide association study between prenatal and childhood exposome and age acceleration. Maternal tobacco smoking during pregnancy was nominally associated with increased age acceleration. For childhood exposures, indoor particulate matter absorbance (PMabs) and parental smoking were nominally associated with an increase in age acceleration. Exposure to the organic pesticide dimethyl dithiophosphate and the persistent pollutant polychlorinated biphenyl-138 (inversely associated with child body mass index) were protective for age acceleration. None of the associations remained significant after multiple-testing correction. Pregnancy and childhood exposure to tobacco smoke and childhood exposure to indoor PMabs may accelerate epigenetic aging from an early age SI
ACU Research Bank arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2021License: CC BYData sources: Spiral - Imperial College Digital RepositoryEnvironment InternationalOther literature type . Article . 2021 . Peer-reviewedLicense: Elsevier TDMMinerva. Repositorio Institucional da Universidade de Santiago de CompostelaArticle . 2021License: CC BYRecolector de Ciencia Abierta, RECOLECTAArticle . 2021License: CC BYData sources: Recolector de Ciencia Abierta, RECOLECTAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 42 citations 42 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 2visibility views 2 download downloads 24 Powered bymore_vert ACU Research Bank arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2021License: CC BYData sources: Spiral - Imperial College Digital RepositoryEnvironment InternationalOther literature type . Article . 2021 . Peer-reviewedLicense: Elsevier TDMMinerva. Repositorio Institucional da Universidade de Santiago de CompostelaArticle . 2021License: CC BYRecolector de Ciencia Abierta, RECOLECTAArticle . 2021License: CC BYData sources: Recolector de Ciencia Abierta, RECOLECTAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.envint.2021.106683&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article , Preprint 2020 United Kingdom, United Kingdom, Netherlands, SwitzerlandPublisher:Copernicus GmbH Funded by:NSF | Department of Energy (DoE..., EC | ERA4CS, SNSF | Constraining dynamic and ...NSF| Department of Energy (DoE) Support of the National Center for Atmospheric Research Activities ,EC| ERA4CS ,SNSF| Constraining dynamic and thermodynamic drivers of mid-term regional climate change projections for Northern mid-latitudesG. J. van Oldenborgh; F. Krikken; S. Lewis; N. J. Leach; F. Lehner; F. Lehner; F. Lehner; K. R. Saunders; M. van Weele; K. Haustein; S. Li; S. Li; D. Wallom; S. Sparrow; J. Arrighi; J. Arrighi; R. K. Singh; M. K. van Aalst; M. K. van Aalst; M. K. van Aalst; S. Y. Philip; R. Vautard; F. E. L. Otto;Disastrous bushfires during the last months of 2019 and January 2020 affected Australia, raising the question to what extent the risk of these fires was exacerbated by anthropogenic climate change. To answer the question for southeastern Australia, where fires were particularly severe, affecting people and ecosystems, we use a physically based index of fire weather, the Fire Weather Index; long-term observations of heat and drought; and 11 large ensembles of state-of-the-art climate models. We find large trends in the Fire Weather Index in the fifth-generation European Centre for Medium-Range Weather Forecasts (ECMWF) Atmospheric Reanalysis (ERA5) since 1979 and a smaller but significant increase by at least 30 % in the models. Therefore, we find that climate change has induced a higher weather-induced risk of such an extreme fire season. This trend is mainly driven by the increase of temperature extremes. In agreement with previous analyses we find that heat extremes have become more likely by at least a factor of 2 due to the long-term warming trend. However, current climate models overestimate variability and tend to underestimate the long-term trend in these extremes, so the true change in the likelihood of extreme heat could be larger, suggesting that the attribution of the increased fire weather risk is a conservative estimate. We do not find an attributable trend in either extreme annual drought or the driest month of the fire season, September–February. The observations, however, show a weak drying trend in the annual mean. For the 2019/20 season more than half of the July–December drought was driven by record excursions of the Indian Ocean Dipole and Southern Annular Mode, factors which are included in the analysis here. The study reveals the complexity of the 2019/20 bushfire event, with some but not all drivers showing an imprint of anthropogenic climate change. Finally, the study concludes with a qualitative review of various vulnerability and exposure factors that each play a role, along with the hazard in increasing or decreasing the overall impact of the bushfires. Natural Hazards and Earth System Sciences, 21 (3) ISSN:1561-8633 ISSN:1684-9981
Natural Hazards and ... arrow_drop_down Natural Hazards and Earth System SciencesArticle . 2021Full-Text: https://ezproxy2.utwente.nl/login?url=https://library.itc.utwente.nl/login/2021/isi/vanaalst_att.pdfData sources: NARCISNARCIS; Natural Hazards and Earth System SciencesArticle . 2021Copernicus Publications; Natural Hazards and Earth System Sciences (NHESS)Other literature type . 2021Data sources: Copernicus PublicationsNatural Hazards and Earth System Sciences (NHESS)Other literature type . 2020Data sources: Copernicus Publicationshttps://doi.org/10.5194/nhess-...Preprint . 2020 . Peer-reviewedLicense: CC BYData sources: CrossrefSpiral - Imperial College Digital RepositoryArticle . 2021License: CC BYData sources: Spiral - Imperial College Digital RepositoryOxford University Research ArchiveArticle . 2021License: CC BYData sources: Oxford University Research ArchiveNatural Hazards and Earth System SciencesArticle . 2021 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 194 citations 194 popularity Top 0.1% influence Top 10% impulse Top 0.1% Powered by BIP!visibility 127visibility views 127 download downloads 258 Powered bymore_vert Natural Hazards and ... arrow_drop_down Natural Hazards and Earth System SciencesArticle . 2021Full-Text: https://ezproxy2.utwente.nl/login?url=https://library.itc.utwente.nl/login/2021/isi/vanaalst_att.pdfData sources: NARCISNARCIS; Natural Hazards and Earth System SciencesArticle . 2021Copernicus Publications; Natural Hazards and Earth System Sciences (NHESS)Other literature type . 2021Data sources: Copernicus PublicationsNatural Hazards and Earth System Sciences (NHESS)Other literature type . 2020Data sources: Copernicus Publicationshttps://doi.org/10.5194/nhess-...Preprint . 2020 . Peer-reviewedLicense: CC BYData sources: CrossrefSpiral - Imperial College Digital RepositoryArticle . 2021License: CC BYData sources: Spiral - Imperial College Digital RepositoryOxford University Research ArchiveArticle . 2021License: CC BYData sources: Oxford University Research ArchiveNatural Hazards and Earth System SciencesArticle . 2021 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 France, Australia, France, Spain, Italy, United Kingdom, Italy, France, FrancePublisher:Elsevier BV Funded by:EC | ESCAPEEC| ESCAPEEmilie Burte; Bénédicte Leynaert; Alessandro Marcon; Jean Bousquet; Meriem Benmerad; Roberto Bono; Anne-Elie Carsin; Kees de Hoogh; Bertil Forsberg; Frédéric Gormand; Joachim Heinrich; Jocelyne Just; Mark J. Nieuwenhuijsen; Isabelle Pin; Morgane Stempfelet; Jordi Sunyer; Simona Villani; Nino Künzli; Valérie Siroux; Deborah Jarvis; Rachel Nadif; Bénédicte Jacquemin;Background: Very few studies have examined the association between long-term outdoor air pollution and rhinitis severity in adults. Objective: We sought to assess the cross-sectional association between individual long-term exposure to air pollution and severity of rhinitis. Methods: Participants with rhinitis from 2 multicenter European cohorts (Epidemiological Study on the Genetics and Environment on Asthma and the European Community Respiratory Health Survey) were included. Annual exposure to NO2, PM10, PM2.5, and PMcoarse (calculated by subtracting PM2.5 from PM10) was estimated using land-use regression models derived from the European Study of Cohorts for Air Pollution Effects project, at the participants' residential address. The score of rhinitis severity (range, 0-12), based on intensity of disturbance due to symptoms reported by questionnaire, was categorized into low (reference), mild, moderate, and high severity. Polytomous logistic regression models with a random intercept for city were used. Results: A total of 1408 adults with rhinitis (mean age, 52 years; 46% men, 81% from the European Community Respiratory Health Survey) were included. The median (1st quartile-3rd quartile) score of rhinitis severity was 4 (2-6). Higher exposure to PM10 was associated with higher rhinitis severity (adjusted odds ratio [95% CI] for a 10 μg/m3 increase in PM10: for mild: 1.20 [0.88-1.64], moderate: 1.53 [1.07-2.19], and high severity: 1.72 [1.23-2.41]). Similar results were found for PM2.5. Higher exposure to NO2 was associated with an increased severity of rhinitis, with similar adjusted odds ratios whatever the level of severity. Adjusted odds ratios were higher among participants without allergic sensitization than among those with, but interaction was found only for NO2. CONCLUSIONS: People with rhinitis who live in areas with higher levels of pollution are more likely to report more severe nasal symptoms. Further work is required to elucidate the mechanisms of this association. The following bodies funded the local studies in ECRHS III in this article: Belgium: Antwerp South, Antwerp City: Research Foundation Flanders (FWO), grant code G.0.410.08.N.10 (both sites); France: Ministère de la Santé , Programme Hospitalier de Recherche Clinique (PHRC) national 2010; Germany: Erfurt: German Research Foundation ( HE 3294/10-1 ); Spain: Fondo de Investigación Sanitaria ( PS09/02457 , PS09/00716 09/01511 , PS09/02185 , and PS09/03190 ), Servicio Andaluz de Salud, Sociedad Española de Neumología y Cirurgía Torácica ( SEPAR 1001/2010 ); Barcelona: Fondo de Investigación Sanitaria ( FIS PS09/00716 ); Galdakao: Fondo de Investigación Sanitaria ( FIS 09/01511 ); Huelva: Fondo de Investigación Sanitaria ( FIS PS09/02185 ) and Servicio Andaluz de Salud ; Oviedo: Fondo de Investigación Sanitaria ( FIS PS09/03190 ); United Kingdom: Medical Research Council (grant no. 92091 ). The Epidemiological Study on the Genetics and Environment on Asthma is funded in part by PHRC-Paris, PHRC-Grenoble, ANR 05-SEST-020-02/05-9-97, ANR-06-CEBS, ANR-CES-2009, Région Nord Pas-de-Calais, and Merck Sharp & Dohme. European Study of Cohorts for Air Pollution Effects Funding: The research leading to these results has received funding from the European Community’s Seventh Framework Program ( FP7/2007-2011 ; under grant agreement no. 211250 )
Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Journal of Allergy and Clinical Immunology; IRIS - Università degli Studi di Verona; UPF Digital RepositoryArticle . 2020 . Peer-reviewedLicense: Elsevier TDMIRIS - Università degli Studi di VeronaArticle . 2020Data sources: IRIS - Università degli Studi di VeronaSpiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital RepositoryHAL Descartes; HAL-Rennes 1; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2020License: CC BY NCadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 43 citations 43 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 1visibility views 1 Powered bymore_vert Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Journal of Allergy and Clinical Immunology; IRIS - Università degli Studi di Verona; UPF Digital RepositoryArticle . 2020 . Peer-reviewedLicense: Elsevier TDMIRIS - Università degli Studi di VeronaArticle . 2020Data sources: IRIS - Università degli Studi di VeronaSpiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital RepositoryHAL Descartes; HAL-Rennes 1; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2020License: CC BY NCadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Spain, Australia, Netherlands, Netherlands, Netherlands, Netherlands, Netherlands, United KingdomPublisher:Elsevier BV Funded by:EC | ENVIROGENOMARKERSEC| ENVIROGENOMARKERSKrauskopf, Julian; van Veldhoven, Karin; Chadeau-Hyam, Marc; Vermeulen, Roel; Carrasco-Turigas, Glòria; Nieuwenhuijsen, Mark; Vineis, Paolo; de Kok, Theo M.; Kleinjans, Jos C.; One Health Chemisch; dIRAS RA-2;Traffic-related air pollution (TRAP) is a complex mixture of compounds that contributes to the pathogenesis of many diseases including several types of cancer, pulmonary, cardiovascular and neurodegenerative diseases, and more recently also diabetes mellitus. In search of an early diagnostic biomarker for improved environmental health risk assessment, recent human studies have shown that certain extracellular miRNAs are altered upon exposure to TRAP. Here, we present a global circulating miRNA analysis in a human population exposed to different levels of TRAP. The cross-over study, with sampling taking place during resting and physical activity in two different exposure scenarios, included for each subject personal exposure measurements of PM10,PM2.5, NO, NO2, CO, CO2, BC and UFP. Next-generation sequencing technology was used to identify global circulating miRNA levels across all subjects. We identified 8 miRNAs to be associated with the mixture of TRAP and 27 miRNAs that were associated with the individual pollutants NO, NO2, CO, CO2, BC and UFP. We did not find significant associations between miRNA levels and PM10 or PM2.5. Integrated network analysis revealed that these circulating miRNAs are potentially involved in processes that are implicated in the development of air pollution-induced diseases. Altogether, this study demonstrates that signatures consisting of circulating miRNAs present a potential novel biomarker to be used in health risk assessment. This work has been supported by the European Union within the frame of the Exposomics (226756) project.
NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2019NARCIS; Environment InternationalArticle . 2019Recolector de Ciencia Abierta, RECOLECTA; UPF Digital RepositoryArticle . 2019License: CC BY NC NDSpiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 31 citations 31 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 7visibility views 7 download downloads 47 Powered bymore_vert NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2019NARCIS; Environment InternationalArticle . 2019Recolector de Ciencia Abierta, RECOLECTA; UPF Digital RepositoryArticle . 2019License: CC BY NC NDSpiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.envint.2019.04.063&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Netherlands, Netherlands, France, Norway, United Kingdom, Netherlands, Spain, Netherlands, France, AustraliaPublisher:Environmental Health Perspectives Funded by:EC | ESCAPE, NIH | Pilot Project Program, EC | ENRIECO +1 projectsEC| ESCAPE ,NIH| Pilot Project Program ,EC| ENRIECO ,EC| HELIXNieuwenhuijsen, Mark J.; Agier, Lydiane; Basagana, Xavier; Urquiza, Jose; Tamayo-Uria, Ibon; Giorgis-Allemand, Lise; Robinson, Oliver; Siroux, Valerie; Maitre, Lea; de Castro, Montserrat; Valentin, Antonia; Donaire, David; Dadvand, Payam; Aasvang, Gunn Marit; Krog, Norun Hjertager; Schwarze, Per E.; Chatzi, Leda; Grazuleviciene, Regina; Andrusaityte, Sandra; Dedele, Audrius; McEachan, Rosie; Wright, John; West, Jane; Ibarluzea, Jesus; Ballester, Ferran; Vrijheid, Martine; Slama, Remy;The study has received funding from the European Community’s Seventh Framework Programme (FP7/2007–2013) under Grant Agreement No. 308333—the HELIX project—for data collection and analyses. The HELIX program built on six existing cohorts that received previous funding, including the major cohorts listed here. INMA data collections were supported by grants from the Instituto de Salud Carlos III, CIBERESP, the Conselleria de Sanitat, Generalitat Valenciana, Department of Health of the Basque Government; the Provincial Government of Gipuzkoa, and the Generalitat de Catalunya-CIRIT. KANC was funded by the grant of the Lithuanian Agency for Science Innovation and Technology (6-04-2014_31V-66). MoBa (Norwegian Mother and Child Cohort Study) is supported by the Norwegian Ministry of Health and the Ministry of Education and Research, NIH/NIEHS (Contract No. N01-ES-75558), and the U.S. National Institutes of Health (NIH) National Institute of Environmental Health Sciences (NIEHS; Contract No. N01-ES-75558), and National Institute of Neurological Disorders and Stroke (Grant No. 1 UO1 NS 047537-01 and Grant No. 2 UO1 NS 047537-06A1). The Rhea project was financially supported by European projects (EU FP6–2003-Food-3-NewGeneris, EU FP6.STREP Hiwate, EU FP7 ENV.2007·1.2.2.2, Project No. 211250 Escape, EU FP7–2008-ENV-1·2.1·4 Envirogenomarkers, EU FP7-HEALTH-2009-single stage CHICOS, EU FP7 ENV.2008.1.2.1.6, Proposal No. 226285 ENRIECO, EUFP7-HEALTH-2012 Proposal No. 308333 HELIX, FP7 European Union Project No. 264357 MeDALL), and the Greek Ministry of Health (Program of Prevention of Obesity and Neurodevelopmental Disorders in Preschool Children, in Heraklion district, Crete, Greece: 2011–2014; “Rhea Plus”: Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012–15). L.C. received additional funding from the Southern California Environmental Health Sciences Center (Grant No. P30ES007048) funded by NIEHS. We acknowledge the support of the program for international scientific collaborations of Région Rhône-Alpes-Auvergne. Background: The exposome is defined as the totality of environmental exposures from conception onwards. It calls for providing a holistic view of environmental exposures and their effects on human health by evaluating multiple environmental exposures simultaneously during critical periods of life. Objective: We evaluated the association of the urban exposome with birth weight. Methods: We estimated exposure to the urban exposome, including the built environment, air pollution, road traffic noise, meteorology, natural space, and road traffic (corresponding to 24 environmental indicators and 60 exposures) for nearly 32,000 pregnant women from six European birth cohorts. To evaluate associations with either continuous birth weight or term low birth weight (TLBW) risk, we primarily relied on the Deletion-Substitution-Addition (DSA) algorithm, which is an extension of the stepwise variable selection method. Second, we used an exposure-by-exposure exposome-wide association studies (ExWAS) method accounting for multiple hypotheses testing to report associations not adjusted for coexposures. Results: The most consistent statistically significant associations were observed between increasing green space exposure estimated as Normalized Difference Vegetation Index (NDVI) and increased birth weight and decreased TLBW risk. Furthermore, we observed statistically significant associations among presence of public bus line, land use Shannon's Evenness Index, and traffic density and birth weight in our DSA analysis. Conclusion: This investigation is the first large urban exposome study of birth weight that tests many environmental urban exposures. It confirmed previously reported associations for NDVI and generated new hypotheses for a number of built-environment exposures.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6785228Data sources: PubMed CentralRecolector de Ciencia Abierta, RECOLECTAArticle . 2019Data sources: Recolector de Ciencia Abierta, RECOLECTAEnvironmental Health Perspectives; NARCISArticle . 2019Norwegian Institute of Public Health Open RepositoryArticle . 2019Data sources: Norwegian Institute of Public Health Open RepositorySpiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 54 citations 54 popularity Top 10% influence Top 10% impulse Top 1% Powered by BIP!visibility 7visibility views 7 download downloads 45 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6785228Data sources: PubMed CentralRecolector de Ciencia Abierta, RECOLECTAArticle . 2019Data sources: Recolector de Ciencia Abierta, RECOLECTAEnvironmental Health Perspectives; NARCISArticle . 2019Norwegian Institute of Public Health Open RepositoryArticle . 2019Data sources: Norwegian Institute of Public Health Open RepositorySpiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1289/ehp3971&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2019 France, Spain, France, France, United Kingdom, AustraliaPublisher:Elsevier BV Funded by:NIH | Pilot Project Program, EC | ENRIECO, EC | ESCAPE +2 projectsNIH| Pilot Project Program ,EC| ENRIECO ,EC| ESCAPE ,EC| HELIX ,NIH| Gene-Environment Interactions in an Autism Birth CohortIbon Tamayo-Uria; Léa Maitre; Cathrine Thomsen; Mark J. Nieuwenhuijsen; Leda Chatzi; Valérie Siroux; Gunn Marit Aasvang; Lydiane Agier; Sandra Andrusaityte; Maribel Casas; Montserrat de Castro; Audrius Dedele; Line Småstuen Haug; Barbara Heude; Regina Grazuleviciene; Kristine B. Gutzkow; Norun Hjertager Krog; Dan Mason; Rosemary R. C. McEachan; Helle Margrete Meltzer; Inga Petraviciene; Oliver Robinson; Theano Roumeliotaki; Amrit Kaur Sakhi; Jose Urquiza; Marina Vafeiadi; Dagmar Waiblinger; Charline Warembourg; John Wright; Rémy Slama; Martine Vrijheid; Xavier Basagaña;Characterization of the "exposome", the set of all environmental factors that one is exposed to from conception onwards, has been advocated to better understand the role of environmental factors on chronic diseases. Here, we aimed to describe the early-life exposome. Specifically, we focused on the correlations between multiple environmental exposures, their patterns and their variability across European regions and across time (pregnancy and childhood periods). We relied on the Human Early-Life Exposome (HELIX) project, in which 87 environmental exposures during pregnancy and 122 during the childhood period (grouped in 19 exposure groups) were assessed in 1301 pregnant mothers and their children at 6-11 years in 6 European birth cohorts. Some correlations between exposures in the same exposure group reached high values above 0.8. The median correlation within exposure groups was >0.3 for many exposure groups, reaching 0.69 for water disinfection by products in pregnancy and 0.67 for the meteorological group in childhood. Median correlations between different exposure groups rarely reached 0.3. Some correlations were driven by cohort-level associations (e.g. air pollution and chemicals). Ten principal components explained 45% and 39% of the total variance in the pregnancy and childhood exposome, respectively, while 65 and 90 components were required to explain 95% of the exposome variability. Correlations between maternal (pregnancy) and childhood exposures were high (>0.6) for most exposures modeled at the residential address (e.g. air pollution), but were much lower and even close to zero for some chemical exposures. In conclusion, the early life exposome was high dimensional, meaning that it cannot easily be measured by or reduced to fewer components. Correlations between exposures from different exposure groups were much lower than within exposure groups, which have important implications for co-exposure confounding in multiple exposure studies. Also, we observed the early life exposome to be variable over time and to vary by cohort, so measurements at one time point or one place will not capture its complexities. This work was supported by the European Commission Seventh Framework Programme (FP7/2007–2013) [grant number: 308333–the HELIX project]. INMA data collections were supported by grants from the Instituto de Salud Carlos III, CIBERESP, and the Generalitat de Catalunya-CIRIT. KANC was funded by the grant of the Lithuanian Agency for Science Innovation and Technology (6-04-2014_31V-66). The Norwegian Mother and Child Cohort Study is supported by the Norwegian Ministry of Health and Care Services and the Ministry of Education and Research, NIH/NIEHS (contract no N01-ES-75558), NIH/NINDS (grant no.1 UO1 NS 047537-01 and grant no.2 UO1 NS 047537-06A1). The Rhea project was financially supported by European projects (EU FP6-2003-Food-3-NewGeneris, EU FP6. STREP Hiwate, EU FP7 ENV.2007.1.2.2.2. Project No 211250 Escape, EU FP7-2008-ENV-1.2.1.4 Envirogenomarkers, EU FP7-HEALTH-2009-single stage CHICOS, EU FP7 ENV.2008.1.2.1.6. Proposal No 226285 ENRIECO, EUFP7-HEALTH-2012 Proposal No 308333 HELIX, FP7 European Union project, No. 264357 MeDALL), and the Greek Ministry of Health (Program of Prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece: 2011–2014; “Rhea Plus”: Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012–15).
ACU Research Bank arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; UPF Digital RepositoryArticle . 2019License: CC BY NC NDSpiral - Imperial College Digital RepositoryArticle . 2018Data sources: Spiral - Imperial College Digital RepositoryHAL Descartes; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2019License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 87 citations 87 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 6visibility views 6 download downloads 60 Powered bymore_vert ACU Research Bank arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; UPF Digital RepositoryArticle . 2019License: CC BY NC NDSpiral - Imperial College Digital RepositoryArticle . 2018Data sources: Spiral - Imperial College Digital RepositoryHAL Descartes; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2019License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018 Australia, France, United Kingdom, Netherlands, France, Spain Funded by:NIH | Pilot Project Program, EC | ENRIECO, EC | ESCAPE +1 projectsNIH| Pilot Project Program ,EC| ENRIECO ,EC| ESCAPE ,EC| HELIXAgier, Lydiane; Basagaña Flores, Xavier; Maitre, Lea; Granum, Berit; Bird, Philippa K.; Casas Sanahuja, Maribel; Oftedal, Bente; Wright, John; Andrusaityte, Sandra; de Castro, Montserrat; Cequier Manciñeiras, Enrique; Chatzi, Leda; Donaire Gonzalez, David; Grazuleviciene, Regina; Haug, Line S.; Sakhi, Amrit Kaur; Leventakou, Vasiliki; McEachan, Rosemary; Nieuwenhuijsen, Mark J.; Petraviciene, Inga; Robinson, Oliver; Roumeliotaki, Theano; Sunyer, Jordi; Tamayo-Uria, Ibon; Thomsen, Cathrine; Urquiza, José; Valentín, Antònia; Slama, Rémy; Vrijheid, Martine; Siroux, Valérie;pmid: 32293903
handle: 10459.1/68496
BACKGROUND: Several single-exposure studies have documented possible effects of environmental factors on lung function, but none has relied on an exposome approach. We aimed to evaluate the association between a broad range of prenatal and postnatal lifestyle and environmental exposures and lung function in children.METHODS: In this analysis, we used data from 1033 mother-child pairs from the European Human Early-Life Exposome (HELIX) cohort (consisting of six existing longitudinal birth cohorts in France, Greece, Lithuania, Norway, Spain, and the UK of children born between 2003 and 2009) for whom a valid spirometry test was recorded for the child. 85 prenatal and 125 postnatal exposures relating to outdoor, indoor, chemical, and lifestyle factors were assessed, and lung function was measured by spirometry in children at age 6-12 years. Two agnostic linear regression methods, a deletion-substitution-addition (DSA) algorithm considering all exposures simultaneously, and an exposome-wide association study (ExWAS) considering exposures independently, were applied to test the association with forced expiratory volume in 1 s percent predicted values (FEV1%). We tested for two-way interaction between exposures and corrected for confounding by co-exposures.FINDINGS: In the 1033 children (median age 8·1 years, IQR 6·5-9·0), mean FEV1% was 98·8% (SD 13·2). In the ExWAS, prenatal perfluorononanoate (p=0·034) and perfluorooctanoate (p=0·030) exposures were associated with lower FEV1%, and inverse distance to nearest road during pregnancy (p=0·030) was associated with higher FEV1%. Nine postnatal exposures were associated with lower FEV1%: copper (p=0·041), ethyl-paraben (p=0·029), five phthalate metabolites (mono-2-ethyl 5-carboxypentyl phthalate [p=0·016], mono-2-ethyl-5-hydroxyhexyl phthalate [p=0·023], mono-2-ethyl-5-oxohexyl phthalate [p=0·0085], mono-4-methyl-7-oxooctyl phthalate [p=0·040], and the sum of di-ethylhexyl phthalate metabolites [p=0·014]), house crowding (p=0·015), and facility density around schools (p=0·027). However, no exposure passed the significance threshold when corrected for multiple testing in ExWAS, and none was selected with the DSA algorithm, including when testing for exposure interactions.INTERPRETATION: Our systematic exposome approach identified several environmental exposures, mainly chemicals, that might be associated with lung function. Reducing exposure to these ubiquitous chemicals could help to prevent the development of chronic respiratory disease.FUNDING: European Community's Seventh Framework Programme (HELIX project).
ACU Research Bank arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2019License: CC BY NC NDData sources: Recolector de Ciencia Abierta, RECOLECTASpiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital RepositoryNARCIS; The Lancet Planetary HealthArticle . 2019HAL-Inserm; Hal-DiderotArticle . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert ACU Research Bank arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2019License: CC BY NC NDData sources: Recolector de Ciencia Abierta, RECOLECTASpiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital RepositoryNARCIS; The Lancet Planetary HealthArticle . 2019HAL-Inserm; Hal-DiderotArticle . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018Embargo end date: 01 Jan 2018 Switzerland, United Kingdom, Austria EnglishPublisher:ETH Zurich Funded by:EC | CD-LINKS, EC | CRESCENDOEC| CD-LINKS ,EC| CRESCENDOAuthors: Mengel, Matthias; Nauels, Alexander; Rogelj, Joeri; Schleussner, Carl-Friedrich;Mengel, Matthias; Nauels, Alexander; Rogelj, Joeri; Schleussner, Carl-Friedrich;Sea-level rise is a major consequence of climate change that will continue long after emissions of greenhouse gases have stopped. The 2015 Paris Agreement aims at reducing climate-related risks by reducing greenhouse gas emissions to net zero and limiting global-mean temperature increase. Here we quantify the effect of these constraints on global sea-level rise until 2300, including Antarctic ice-sheet instabilities. We estimate median sea-level rise between 0.7 and 1.2 m, if net-zero greenhouse gas emissions are sustained until 2300, varying with the pathway of emissions during this century. Temperature stabilization below 2 °C is insufficient to hold median sea-level rise until 2300 below 1.5 m. We find that each 5-year delay in near-term peaking of CO2 emissions increases median year 2300 sea-level rise estimates by ca. 0.2 m, and extreme sea-level rise estimates at the 95th percentile by up to 1 m. Our results underline the importance of near-term mitigation action for limiting long-term sea-level rise risks. Nature Communications, 9 (1) ISSN:2041-1723
Nature Communication... arrow_drop_down Europe PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC5820313Data sources: PubMed CentralSpiral - Imperial College Digital RepositoryArticle . 2018Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 10 citations 10 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 17visibility views 17 download downloads 23 Powered bymore_vert Nature Communication... arrow_drop_down Europe PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC5820313Data sources: PubMed CentralSpiral - Imperial College Digital RepositoryArticle . 2018Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2022 Australia, United Kingdom, Spain, NorwayPublisher:Springer Science and Business Media LLC Funded by:EC | ENRIECO, EC | ESCAPE, EC | ATHLETE +1 projectsEC| ENRIECO ,EC| ESCAPE ,EC| ATHLETE ,EC| HELIXLéa Maitre; Mariona Bustamante; Carles Hernández-Ferrer; Denise Thiel; Chung-Ho E. Lau; Alexandros P. Siskos; Marta Vives-Usano; Carlos Ruiz-Arenas; Dolors Pelegrí-Sisó; Oliver Robinson; Dan Mason; John Wright; Solène Cadiou; Rémy Slama; Barbara Heude; Maribel Casas; Jordi Sunyer; Eleni Z. Papadopoulou; Kristine B. Gutzkow; Sandra Andrusaityte; Regina Grazuleviciene; Marina Vafeiadi; Leda Chatzi; Amrit K. Sakhi; Cathrine Thomsen; Ibon Tamayo; Mark Nieuwenhuijsen; Jose Urquiza; Eva Borràs; Eduard Sabidó; Inés Quintela; Ángel Carracedo; Xavier Estivill; Muireann Coen; Juan R. González; Hector C. Keun; Martine Vrijheid;We would like to thank all the families for their generous contribution. The study has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 874583 (ATHLETE project). Data were collected as part of the European Community’s Seventh Framework Programme (FP7/2007-206) under grant agreement no 308333 (HELIX project). BiB received core infrastructure funding from the Wellcome Trust (WT101597MA) and a joint grant from the UK Medical Research Council (MRC) and Economic and Social Science Research Council (ESRC) (MR/N024397/1). INMA data collections were supported by grants from the Instituto de Salud Carlos III, CIBERESP, and the Generalitat de Catalunya-CIRIT. KANC was funded by the grant of the Lithuanian Agency for Science Innovation and Technology (6-04-2014_31V-66). The Norwegian Mother, Father and Child Cohort Study is supported by the Norwegian Ministry of Health and Care Services and the Ministry of Education and Research. The Rhea project was financially supported by European projects (EU FP6-2003-Food-3-NewGeneris, EU FP6. STREP Hiwate, EU FP7 ENV.2007.1.2.2.2. Project No 211250 Escape, EU FP7-2008-ENV-1.2.1.4 Envirogenomarkers, EU FP7-HEALTH-2009- single stage CHICOS, EU FP7 ENV.2008.1.2.1.6. Proposal No 226285 ENRIECO, EU- FP7- HEALTH-2012 Proposal No 308333 HELIX), and the Greek Ministry of Health (Program of Prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece: 2011-2014; “Rhea Plus”: Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012-15). ISGlobal acknowledges support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. L.M. is funded by a Juan de la Cierva-Incorporación fellowship (IJC2018-035394-I) awarded by the Spanish Ministerio de Economía, Industria y Competitividad. M.V.-U. and C.R.-A. were supported by a FI fellowship from the Catalan Government (FI-DGR 2015 and #016FI_B 00272). M. Casas received funding from Instituto Carlos III (Ministry of Economy and Competitiveness) (CD12/00563 and MS16/00128). Environmental exposures during early life play a critical role in life-course health, yet the molecular phenotypes underlying environmental effects on health are poorly understood. In the Human Early Life Exposome (HELIX) project, a multi-centre cohort of 1301 mother-child pairs, we associate individual exposomes consisting of >100 chemical, outdoor, social and lifestyle exposures assessed in pregnancy and childhood, with multi-omics profiles (methylome, transcriptome, proteins and metabolites) in childhood. We identify 1170 associations, 249 in pregnancy and 921 in childhood, which reveal potential biological responses and sources of exposure. Pregnancy exposures, including maternal smoking, cadmium and molybdenum, are predominantly associated with child DNA methylation changes. In contrast, childhood exposures are associated with features across all omics layers, most frequently the serum metabolome, revealing signatures for diet, toxic chemical compounds, essential trace elements, and weather conditions, among others. Our comprehensive and unique resource of all associations ( https://helixomics.isglobal.org/ ) will serve to guide future investigation into the biological imprints of the early life exposome.
UPF Digital Reposito... arrow_drop_down UPF Digital Repository; Nature CommunicationsOther literature type . Article . 2022 . Peer-reviewedLicense: CC BYNorwegian Institute of Public Health Open RepositoryArticle . 2022Data sources: Norwegian Institute of Public Health Open RepositorySpiral - Imperial College Digital RepositoryArticle . 2022License: CC BYData sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 24 citations 24 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 6visibility views 6 download downloads 5 Powered bymore_vert UPF Digital Reposito... arrow_drop_down UPF Digital Repository; Nature CommunicationsOther literature type . Article . 2022 . Peer-reviewedLicense: CC BYNorwegian Institute of Public Health Open RepositoryArticle . 2022Data sources: Norwegian Institute of Public Health Open RepositorySpiral - Imperial College Digital RepositoryArticle . 2022License: CC BYData sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2021 Belgium, Switzerland, Norway, United Kingdom, France, SpainPublisher:Copernicus GmbH Funded by:SNSF | The role of Southern Ocea..., SNSF | Impact of interactions be..., EC | ERA-PLANET +3 projectsSNSF| The role of Southern Ocean stratification in future ocean CO2 and heat uptake ,SNSF| Impact of interactions between microorganisms on iron and carbon recycling in the Southern Ocean : consequences for iron limitation ,EC| ERA-PLANET ,SNSF| Natural Atmospheric new particle formation (NAPF) ,SNSF| Antarctic precipitation, snow accumulation processes, and ice-ocean interactions ,SNSF| The role of Southern Ocean stratification in future ocean CO2 and heat uptakeS. Landwehr; M. Volpi; F. A. Haumann; F. A. Haumann; C. M. Robinson; I. Thurnherr; I. Thurnherr; V. Ferracci; A. Baccarini; A. Baccarini; J. Thomas; I. Gorodetskaya; I. Gorodetskaya; C. Tatzelt; S. Henning; R. L. Modini; H. J. Forrer; H. J. Forrer; Y. Lin; Y. Lin; Y. Lin; N. Cassar; N. Cassar; R. Simó; C. Hassler; C. Hassler; A. Moallemi; S. E. Fawcett; N. Harris; R. Airs; M. H. Derkani; A. Alberello; A. Toffoli; G. Chen; P. Rodríguez-Ros; M. Zamanillo; P. Cortés-Greus; L. Xue; C. G. Bolas; K. C. Leonard; K. C. Leonard; F. Perez-Cruz; F. Perez-Cruz; D. Walton; J. Schmale;handle: 10261/258325 , 11250/2987421
The Southern Ocean is a critical component of Earth's climate system, but its remoteness makes it challenging to develop a holistic understanding of its processes from the small scale to the large scale. As a result, our knowledge of this vast region remains largely incomplete. The Antarctic Circumnavigation Expedition (ACE, austral summer 2016/2017) surveyed a large number of variables describing the state of the ocean and the atmosphere, the freshwater cycle, atmospheric chemistry, and ocean biogeochemistry and microbiology. This circumpolar cruise included visits to 12 remote islands, the marginal ice zone, and the Antarctic coast. Here, we use 111 of the observed variables to study the latitudinal gradients, seasonality, shorter-term variations, geographic setting of environmental processes, and interactions between them over the duration of 90 d. To reduce the dimensionality and complexity of the dataset and make the relations between variables interpretable we applied an unsupervised machine learning method, the sparse principal component analysis (sPCA), which describes environmental processes through 14 latent variables. To derive a robust statistical perspective on these processes and to estimate the uncertainty in the sPCA decomposition, we have developed a bootstrap approach. Our results provide a proof of concept that sPCA with uncertainty analysis is able to identify temporal patterns from diurnal to seasonal cycles, as well as geographical gradients and “hotspots” of interaction between environmental compartments. While confirming many well known processes, our analysis provides novel insights into the Southern Ocean water cycle (freshwater fluxes), trace gases (interplay between seasonality, sources, and sinks), and microbial communities (nutrient limitation and island mass effects at the largest scale ever reported). More specifically, we identify the important role of the oceanic circulations, frontal zones, and islands in shaping the nutrient availability that controls biological community composition and productivity; the fact that sea ice controls sea water salinity, dampens the wave field, and is associated with increased phytoplankton growth and net community productivity possibly due to iron fertilisation and reduced light limitation; and the clear regional patterns of aerosol characteristics that have emerged, stressing the role of the sea state, atmospheric chemical processing, and source processes near hotspots for the availability of cloud condensation nuclei and hence cloud formation. A set of key variables and their combinations, such as the difference between the air and sea surface temperature, atmospheric pressure, sea surface height, geostrophic currents, upper-ocean layer light intensity, surface wind speed and relative humidity played an important role in our analysis, highlighting the necessity for Earth system models to represent them adequately. In conclusion, our study highlights the use of sPCA to identify key ocean–atmosphere interactions across physical, chemical, and biological processes and their associated spatio-temporal scales. It thereby fills an important gap between simple correlation analyses and complex Earth system models. The sPCA processing code is available as open-access from the following link: https://renkulab.io/gitlab/ACE-ASAID/spca-decomposition (last access: 29 March 2021). As we show here, it can be used for an exploration of environmental data that is less prone to cognitive biases (and confirmation biases in particular) compared to traditional regression analysis that might be affected by the underlying research question 75 pages, 8 figures, 3 tables, 6 appendixes, supplement https://doi.org/10.5194/esd-12-1295-2021-supplement.-- Code and data availability: The python code that was used for the analysis and to create the plots is available at https://renkulab.io/gitlab/ACE-ASAID/spca-decomposition (last access: 29 March 2021; Volpi, 2021) and as a Renku project https://renkulab.io/projects/ACE-ASAID/spca-decomposition (last access: 29 March 2021; Volpi and Landwehr, 2021). For the availability of the data used in this study please refer to Tables B1 to B8 in Appendix B Rafel Simó, Marina Zamanillo, Pau Cortés-Greus, and Pablo Rodríguez-Ros were supported by the Spanish Ministry of Science through the BIOGAPS project (CTM2016-81008-R) With the institutional support of the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000928-S) Peer reviewed
Copernicus Publicati... arrow_drop_down Copernicus Publications; NERC Open Research ArchiveOther literature type . Article . 2021 . Peer-reviewedUniversity of East Anglia digital repositoryArticle . 2021 . Peer-reviewedData sources: University of East Anglia digital repositoryArchiMer - Institutional Archive of IfremerOther literature type . 2021Data sources: ArchiMer - Institutional Archive of IfremerArchiMer - Institutional Archive of IfremerOther literature type . 2021Data sources: ArchiMer - Institutional Archive of IfremerSpiral - Imperial College Digital RepositoryArticle . 2021License: CC BYData sources: Spiral - Imperial College Digital RepositoryRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021 . Peer-reviewedInfoscience - EPFL scientific publicationsArticleData sources: Infoscience - EPFL scientific publicationsBergen Open Research Archive - UiB; Norwegian Open Research ArchivesArticle . 2021 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 11 citations 11 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 50visibility views 50 download downloads 104 Powered bymore_vert Copernicus Publicati... arrow_drop_down Copernicus Publications; NERC Open Research ArchiveOther literature type . Article . 2021 . Peer-reviewedUniversity of East Anglia digital repositoryArticle . 2021 . Peer-reviewedData sources: University of East Anglia digital repositoryArchiMer - Institutional Archive of IfremerOther literature type . 2021Data sources: ArchiMer - Institutional Archive of IfremerArchiMer - Institutional Archive of IfremerOther literature type . 2021Data sources: ArchiMer - Institutional Archive of IfremerSpiral - Imperial College Digital RepositoryArticle . 2021License: CC BYData sources: Spiral - Imperial College Digital RepositoryRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021 . Peer-reviewedInfoscience - EPFL scientific publicationsArticleData sources: Infoscience - EPFL scientific publicationsBergen Open Research Archive - UiB; Norwegian Open Research ArchivesArticle . 2021 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 United Kingdom, Australia, SpainPublisher:Elsevier BV Funded by:EC | ESCAPE, EC | LIFECYCLE, UKRI | Metabolomic and omic asse... +4 projectsEC| ESCAPE ,EC| LIFECYCLE ,UKRI| Metabolomic and omic assessment of biological ageing across the life-course (METAGE) ,EC| ENRIECO ,WT| The Born in Bradford (BiB) Study an international biomedical resource for exploring genetic and early life determinants of health and development in a deprived multi-ethnic population. ,EC| HELIX ,EC| ATHLETEAuthors: Prado Bert, Paula de; Ruiz-Arenas, Carlos; Vives-Usano, Marta; Andrusaityte, Sandra; +22 AuthorsPrado Bert, Paula de; Ruiz-Arenas, Carlos; Vives-Usano, Marta; Andrusaityte, Sandra; Cadiou, Solène; Carracedo Álvarez, Ángel María; Casas, Maribel; Chatzi, Leda; Dadvand, Payam; González Ruiz, Juan Ramon; Grazuleviciene, Regina; Gutzkow, Kristine Bjerve; Haug, Line Småstuen; Hernandez Ferrer, Carles; Keun, Hector C.; Lepeule, Johanna; Maitre, Léa; McEachan, Rosemary; Nieuwenhuijsen, Mark J.; Pelegrí, Dolors; Robinson, Oliver; Slama, Rémy; Vafeiadi, Marina; Sunyer, Jordi; Vrijheid, Martine; Bustamante, Mariona;The study received funding from the European Community’s Seventh Framework Programme (FP7/2007-206) (grant agreement no 308333) (HELIX project), the H2020-EU.3.1.2. - Preventing Disease Programme (grant agreement no 874583) (ATHLETE project), and from the European Union’s Horizon 2020 research and innovation programme (grant Agreement number: 733206) (Early Life stressors and Lifecycle Health (LIFECYCLE)). BiB received funding from the Welcome Trust (WT101597MA), from the UK Medical Research Council (MRC) and Economic and Social Science Research Council (ESRC) (MR/N024397/1). INMA was supported by grants from the Instituto de Salud Carlos III, CIBERESP, and the Generalitat de Catalunya-CIRIT. KANC was funded by the grant of the Lithuanian Agency for Science Innovation and Technology (6-04-2014_31V-66). The Norwegian Mother, Father and Child Cohort Study is supported by the Norwegian Ministry of Health and Care Services and the Ministry of Education and Research. The Rhea project was financially supported by European projects (EU FP6-2003-Food-3-NewGeneris, EU FP6. STREP Hiwate, EU FP7 ENV.2007.1.2.2.2. Project No 211250 Escape, EU FP7-2008-ENV-1.2.1.4 Envirogenomarkers, EU FP7-HEALTH-2009- single stage CHICOS, EU FP7 ENV.2008.1.2.1.6. Proposal No 226285 ENRIECO, EU- FP7- HEALTH-2012 Proposal No 308333 HELIX), and the Greek Ministry of Health (Program of Prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece: 2011-2014; “Rhea Plus”: Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012-15). We acknowledge support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. OR was funded by a UKRI Future Leaders Fellowship (MR/S03532X/1). MV-U and CR-A were supported by a FI fellowship from the Catalan Government (FI-DGR 2015 and #016FI_B 00272). MC received funding from Instituto Carlos III (Ministry of Economy and Competitiveness) (CD12/00563 and MS16/00128) The early-life exposome influences future health and accelerated biological aging has been proposed as one of the underlying biological mechanisms. We investigated the association between more than 100 exposures assessed during pregnancy and in childhood (including indoor and outdoor air pollutants, built environment, green environments, tobacco smoking, lifestyle exposures, and biomarkers of chemical pollutants), and epigenetic age acceleration in 1,173 children aged 7 years old from the Human Early-Life Exposome project. Age acceleration was calculated based on Horvath’s Skin and Blood clock using child blood DNA methylation measured by Infinium HumanMethylation450 BeadChips. We performed an exposure-wide association study between prenatal and childhood exposome and age acceleration. Maternal tobacco smoking during pregnancy was nominally associated with increased age acceleration. For childhood exposures, indoor particulate matter absorbance (PMabs) and parental smoking were nominally associated with an increase in age acceleration. Exposure to the organic pesticide dimethyl dithiophosphate and the persistent pollutant polychlorinated biphenyl-138 (inversely associated with child body mass index) were protective for age acceleration. None of the associations remained significant after multiple-testing correction. Pregnancy and childhood exposure to tobacco smoke and childhood exposure to indoor PMabs may accelerate epigenetic aging from an early age SI
ACU Research Bank arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2021License: CC BYData sources: Spiral - Imperial College Digital RepositoryEnvironment InternationalOther literature type . Article . 2021 . Peer-reviewedLicense: Elsevier TDMMinerva. Repositorio Institucional da Universidade de Santiago de CompostelaArticle . 2021License: CC BYRecolector de Ciencia Abierta, RECOLECTAArticle . 2021License: CC BYData sources: Recolector de Ciencia Abierta, RECOLECTAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 42 citations 42 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 2visibility views 2 download downloads 24 Powered bymore_vert ACU Research Bank arrow_drop_down Spiral - Imperial College Digital RepositoryArticle . 2021License: CC BYData sources: Spiral - Imperial College Digital RepositoryEnvironment InternationalOther literature type . Article . 2021 . Peer-reviewedLicense: Elsevier TDMMinerva. Repositorio Institucional da Universidade de Santiago de CompostelaArticle . 2021License: CC BYRecolector de Ciencia Abierta, RECOLECTAArticle . 2021License: CC BYData sources: Recolector de Ciencia Abierta, RECOLECTAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article , Preprint 2020 United Kingdom, United Kingdom, Netherlands, SwitzerlandPublisher:Copernicus GmbH Funded by:NSF | Department of Energy (DoE..., EC | ERA4CS, SNSF | Constraining dynamic and ...NSF| Department of Energy (DoE) Support of the National Center for Atmospheric Research Activities ,EC| ERA4CS ,SNSF| Constraining dynamic and thermodynamic drivers of mid-term regional climate change projections for Northern mid-latitudesG. J. van Oldenborgh; F. Krikken; S. Lewis; N. J. Leach; F. Lehner; F. Lehner; F. Lehner; K. R. Saunders; M. van Weele; K. Haustein; S. Li; S. Li; D. Wallom; S. Sparrow; J. Arrighi; J. Arrighi; R. K. Singh; M. K. van Aalst; M. K. van Aalst; M. K. van Aalst; S. Y. Philip; R. Vautard; F. E. L. Otto;Disastrous bushfires during the last months of 2019 and January 2020 affected Australia, raising the question to what extent the risk of these fires was exacerbated by anthropogenic climate change. To answer the question for southeastern Australia, where fires were particularly severe, affecting people and ecosystems, we use a physically based index of fire weather, the Fire Weather Index; long-term observations of heat and drought; and 11 large ensembles of state-of-the-art climate models. We find large trends in the Fire Weather Index in the fifth-generation European Centre for Medium-Range Weather Forecasts (ECMWF) Atmospheric Reanalysis (ERA5) since 1979 and a smaller but significant increase by at least 30 % in the models. Therefore, we find that climate change has induced a higher weather-induced risk of such an extreme fire season. This trend is mainly driven by the increase of temperature extremes. In agreement with previous analyses we find that heat extremes have become more likely by at least a factor of 2 due to the long-term warming trend. However, current climate models overestimate variability and tend to underestimate the long-term trend in these extremes, so the true change in the likelihood of extreme heat could be larger, suggesting that the attribution of the increased fire weather risk is a conservative estimate. We do not find an attributable trend in either extreme annual drought or the driest month of the fire season, September–February. The observations, however, show a weak drying trend in the annual mean. For the 2019/20 season more than half of the July–December drought was driven by record excursions of the Indian Ocean Dipole and Southern Annular Mode, factors which are included in the analysis here. The study reveals the complexity of the 2019/20 bushfire event, with some but not all drivers showing an imprint of anthropogenic climate change. Finally, the study concludes with a qualitative review of various vulnerability and exposure factors that each play a role, along with the hazard in increasing or decreasing the overall impact of the bushfires. Natural Hazards and Earth System Sciences, 21 (3) ISSN:1561-8633 ISSN:1684-9981
Natural Hazards and ... arrow_drop_down Natural Hazards and Earth System SciencesArticle . 2021Full-Text: https://ezproxy2.utwente.nl/login?url=https://library.itc.utwente.nl/login/2021/isi/vanaalst_att.pdfData sources: NARCISNARCIS; Natural Hazards and Earth System SciencesArticle . 2021Copernicus Publications; Natural Hazards and Earth System Sciences (NHESS)Other literature type . 2021Data sources: Copernicus PublicationsNatural Hazards and Earth System Sciences (NHESS)Other literature type . 2020Data sources: Copernicus Publicationshttps://doi.org/10.5194/nhess-...Preprint . 2020 . Peer-reviewedLicense: CC BYData sources: CrossrefSpiral - Imperial College Digital RepositoryArticle . 2021License: CC BYData sources: Spiral - Imperial College Digital RepositoryOxford University Research ArchiveArticle . 2021License: CC BYData sources: Oxford University Research ArchiveNatural Hazards and Earth System SciencesArticle . 2021 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 194 citations 194 popularity Top 0.1% influence Top 10% impulse Top 0.1% Powered by BIP!visibility 127visibility views 127 download downloads 258 Powered bymore_vert Natural Hazards and ... arrow_drop_down Natural Hazards and Earth System SciencesArticle . 2021Full-Text: https://ezproxy2.utwente.nl/login?url=https://library.itc.utwente.nl/login/2021/isi/vanaalst_att.pdfData sources: NARCISNARCIS; Natural Hazards and Earth System SciencesArticle . 2021Copernicus Publications; Natural Hazards and Earth System Sciences (NHESS)Other literature type . 2021Data sources: Copernicus PublicationsNatural Hazards and Earth System Sciences (NHESS)Other literature type . 2020Data sources: Copernicus Publicationshttps://doi.org/10.5194/nhess-...Preprint . 2020 . Peer-reviewedLicense: CC BYData sources: CrossrefSpiral - Imperial College Digital RepositoryArticle . 2021License: CC BYData sources: Spiral - Imperial College Digital RepositoryOxford University Research ArchiveArticle . 2021License: CC BYData sources: Oxford University Research ArchiveNatural Hazards and Earth System SciencesArticle . 2021 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 France, Australia, France, Spain, Italy, United Kingdom, Italy, France, FrancePublisher:Elsevier BV Funded by:EC | ESCAPEEC| ESCAPEEmilie Burte; Bénédicte Leynaert; Alessandro Marcon; Jean Bousquet; Meriem Benmerad; Roberto Bono; Anne-Elie Carsin; Kees de Hoogh; Bertil Forsberg; Frédéric Gormand; Joachim Heinrich; Jocelyne Just; Mark J. Nieuwenhuijsen; Isabelle Pin; Morgane Stempfelet; Jordi Sunyer; Simona Villani; Nino Künzli; Valérie Siroux; Deborah Jarvis; Rachel Nadif; Bénédicte Jacquemin;Background: Very few studies have examined the association between long-term outdoor air pollution and rhinitis severity in adults. Objective: We sought to assess the cross-sectional association between individual long-term exposure to air pollution and severity of rhinitis. Methods: Participants with rhinitis from 2 multicenter European cohorts (Epidemiological Study on the Genetics and Environment on Asthma and the European Community Respiratory Health Survey) were included. Annual exposure to NO2, PM10, PM2.5, and PMcoarse (calculated by subtracting PM2.5 from PM10) was estimated using land-use regression models derived from the European Study of Cohorts for Air Pollution Effects project, at the participants' residential address. The score of rhinitis severity (range, 0-12), based on intensity of disturbance due to symptoms reported by questionnaire, was categorized into low (reference), mild, moderate, and high severity. Polytomous logistic regression models with a random intercept for city were used. Results: A total of 1408 adults with rhinitis (mean age, 52 years; 46% men, 81% from the European Community Respiratory Health Survey) were included. The median (1st quartile-3rd quartile) score of rhinitis severity was 4 (2-6). Higher exposure to PM10 was associated with higher rhinitis severity (adjusted odds ratio [95% CI] for a 10 μg/m3 increase in PM10: for mild: 1.20 [0.88-1.64], moderate: 1.53 [1.07-2.19], and high severity: 1.72 [1.23-2.41]). Similar results were found for PM2.5. Higher exposure to NO2 was associated with an increased severity of rhinitis, with similar adjusted odds ratios whatever the level of severity. Adjusted odds ratios were higher among participants without allergic sensitization than among those with, but interaction was found only for NO2. CONCLUSIONS: People with rhinitis who live in areas with higher levels of pollution are more likely to report more severe nasal symptoms. Further work is required to elucidate the mechanisms of this association. The following bodies funded the local studies in ECRHS III in this article: Belgium: Antwerp South, Antwerp City: Research Foundation Flanders (FWO), grant code G.0.410.08.N.10 (both sites); France: Ministère de la Santé , Programme Hospitalier de Recherche Clinique (PHRC) national 2010; Germany: Erfurt: German Research Foundation ( HE 3294/10-1 ); Spain: Fondo de Investigación Sanitaria ( PS09/02457 , PS09/00716 09/01511 , PS09/02185 , and PS09/03190 ), Servicio Andaluz de Salud, Sociedad Española de Neumología y Cirurgía Torácica ( SEPAR 1001/2010 ); Barcelona: Fondo de Investigación Sanitaria ( FIS PS09/00716 ); Galdakao: Fondo de Investigación Sanitaria ( FIS 09/01511 ); Huelva: Fondo de Investigación Sanitaria ( FIS PS09/02185 ) and Servicio Andaluz de Salud ; Oviedo: Fondo de Investigación Sanitaria ( FIS PS09/03190 ); United Kingdom: Medical Research Council (grant no. 92091 ). The Epidemiological Study on the Genetics and Environment on Asthma is funded in part by PHRC-Paris, PHRC-Grenoble, ANR 05-SEST-020-02/05-9-97, ANR-06-CEBS, ANR-CES-2009, Région Nord Pas-de-Calais, and Merck Sharp & Dohme. European Study of Cohorts for Air Pollution Effects Funding: The research leading to these results has received funding from the European Community’s Seventh Framework Program ( FP7/2007-2011 ; under grant agreement no. 211250 )
Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Journal of Allergy and Clinical Immunology; IRIS - Università degli Studi di Verona; UPF Digital RepositoryArticle . 2020 . Peer-reviewedLicense: Elsevier TDMIRIS - Università degli Studi di VeronaArticle . 2020Data sources: IRIS - Università degli Studi di VeronaSpiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital RepositoryHAL Descartes; HAL-Rennes 1; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2020License: CC BY NCadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 43 citations 43 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 1visibility views 1 Powered bymore_vert Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Journal of Allergy and Clinical Immunology; IRIS - Università degli Studi di Verona; UPF Digital RepositoryArticle . 2020 . Peer-reviewedLicense: Elsevier TDMIRIS - Università degli Studi di VeronaArticle . 2020Data sources: IRIS - Università degli Studi di VeronaSpiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital RepositoryHAL Descartes; HAL-Rennes 1; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2020License: CC BY NCadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Spain, Australia, Netherlands, Netherlands, Netherlands, Netherlands, Netherlands, United KingdomPublisher:Elsevier BV Funded by:EC | ENVIROGENOMARKERSEC| ENVIROGENOMARKERSKrauskopf, Julian; van Veldhoven, Karin; Chadeau-Hyam, Marc; Vermeulen, Roel; Carrasco-Turigas, Glòria; Nieuwenhuijsen, Mark; Vineis, Paolo; de Kok, Theo M.; Kleinjans, Jos C.; One Health Chemisch; dIRAS RA-2;Traffic-related air pollution (TRAP) is a complex mixture of compounds that contributes to the pathogenesis of many diseases including several types of cancer, pulmonary, cardiovascular and neurodegenerative diseases, and more recently also diabetes mellitus. In search of an early diagnostic biomarker for improved environmental health risk assessment, recent human studies have shown that certain extracellular miRNAs are altered upon exposure to TRAP. Here, we present a global circulating miRNA analysis in a human population exposed to different levels of TRAP. The cross-over study, with sampling taking place during resting and physical activity in two different exposure scenarios, included for each subject personal exposure measurements of PM10,PM2.5, NO, NO2, CO, CO2, BC and UFP. Next-generation sequencing technology was used to identify global circulating miRNA levels across all subjects. We identified 8 miRNAs to be associated with the mixture of TRAP and 27 miRNAs that were associated with the individual pollutants NO, NO2, CO, CO2, BC and UFP. We did not find significant associations between miRNA levels and PM10 or PM2.5. Integrated network analysis revealed that these circulating miRNAs are potentially involved in processes that are implicated in the development of air pollution-induced diseases. Altogether, this study demonstrates that signatures consisting of circulating miRNAs present a potential novel biomarker to be used in health risk assessment. This work has been supported by the European Union within the frame of the Exposomics (226756) project.
NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2019NARCIS; Environment InternationalArticle . 2019Recolector de Ciencia Abierta, RECOLECTA; UPF Digital RepositoryArticle . 2019License: CC BY NC NDSpiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 31 citations 31 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 7visibility views 7 download downloads 47 Powered bymore_vert NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2019NARCIS; Environment InternationalArticle . 2019Recolector de Ciencia Abierta, RECOLECTA; UPF Digital RepositoryArticle . 2019License: CC BY NC NDSpiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.envint.2019.04.063&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2019 Netherlands, Netherlands, France, Norway, United Kingdom, Netherlands, Spain, Netherlands, France, AustraliaPublisher:Environmental Health Perspectives Funded by:EC | ESCAPE, NIH | Pilot Project Program, EC | ENRIECO +1 projectsEC| ESCAPE ,NIH| Pilot Project Program ,EC| ENRIECO ,EC| HELIXNieuwenhuijsen, Mark J.; Agier, Lydiane; Basagana, Xavier; Urquiza, Jose; Tamayo-Uria, Ibon; Giorgis-Allemand, Lise; Robinson, Oliver; Siroux, Valerie; Maitre, Lea; de Castro, Montserrat; Valentin, Antonia; Donaire, David; Dadvand, Payam; Aasvang, Gunn Marit; Krog, Norun Hjertager; Schwarze, Per E.; Chatzi, Leda; Grazuleviciene, Regina; Andrusaityte, Sandra; Dedele, Audrius; McEachan, Rosie; Wright, John; West, Jane; Ibarluzea, Jesus; Ballester, Ferran; Vrijheid, Martine; Slama, Remy;The study has received funding from the European Community’s Seventh Framework Programme (FP7/2007–2013) under Grant Agreement No. 308333—the HELIX project—for data collection and analyses. The HELIX program built on six existing cohorts that received previous funding, including the major cohorts listed here. INMA data collections were supported by grants from the Instituto de Salud Carlos III, CIBERESP, the Conselleria de Sanitat, Generalitat Valenciana, Department of Health of the Basque Government; the Provincial Government of Gipuzkoa, and the Generalitat de Catalunya-CIRIT. KANC was funded by the grant of the Lithuanian Agency for Science Innovation and Technology (6-04-2014_31V-66). MoBa (Norwegian Mother and Child Cohort Study) is supported by the Norwegian Ministry of Health and the Ministry of Education and Research, NIH/NIEHS (Contract No. N01-ES-75558), and the U.S. National Institutes of Health (NIH) National Institute of Environmental Health Sciences (NIEHS; Contract No. N01-ES-75558), and National Institute of Neurological Disorders and Stroke (Grant No. 1 UO1 NS 047537-01 and Grant No. 2 UO1 NS 047537-06A1). The Rhea project was financially supported by European projects (EU FP6–2003-Food-3-NewGeneris, EU FP6.STREP Hiwate, EU FP7 ENV.2007·1.2.2.2, Project No. 211250 Escape, EU FP7–2008-ENV-1·2.1·4 Envirogenomarkers, EU FP7-HEALTH-2009-single stage CHICOS, EU FP7 ENV.2008.1.2.1.6, Proposal No. 226285 ENRIECO, EUFP7-HEALTH-2012 Proposal No. 308333 HELIX, FP7 European Union Project No. 264357 MeDALL), and the Greek Ministry of Health (Program of Prevention of Obesity and Neurodevelopmental Disorders in Preschool Children, in Heraklion district, Crete, Greece: 2011–2014; “Rhea Plus”: Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012–15). L.C. received additional funding from the Southern California Environmental Health Sciences Center (Grant No. P30ES007048) funded by NIEHS. We acknowledge the support of the program for international scientific collaborations of Région Rhône-Alpes-Auvergne. Background: The exposome is defined as the totality of environmental exposures from conception onwards. It calls for providing a holistic view of environmental exposures and their effects on human health by evaluating multiple environmental exposures simultaneously during critical periods of life. Objective: We evaluated the association of the urban exposome with birth weight. Methods: We estimated exposure to the urban exposome, including the built environment, air pollution, road traffic noise, meteorology, natural space, and road traffic (corresponding to 24 environmental indicators and 60 exposures) for nearly 32,000 pregnant women from six European birth cohorts. To evaluate associations with either continuous birth weight or term low birth weight (TLBW) risk, we primarily relied on the Deletion-Substitution-Addition (DSA) algorithm, which is an extension of the stepwise variable selection method. Second, we used an exposure-by-exposure exposome-wide association studies (ExWAS) method accounting for multiple hypotheses testing to report associations not adjusted for coexposures. Results: The most consistent statistically significant associations were observed between increasing green space exposure estimated as Normalized Difference Vegetation Index (NDVI) and increased birth weight and decreased TLBW risk. Furthermore, we observed statistically significant associations among presence of public bus line, land use Shannon's Evenness Index, and traffic density and birth weight in our DSA analysis. Conclusion: This investigation is the first large urban exposome study of birth weight that tests many environmental urban exposures. It confirmed previously reported associations for NDVI and generated new hypotheses for a number of built-environment exposures.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6785228Data sources: PubMed CentralRecolector de Ciencia Abierta, RECOLECTAArticle . 2019Data sources: Recolector de Ciencia Abierta, RECOLECTAEnvironmental Health Perspectives; NARCISArticle . 2019Norwegian Institute of Public Health Open RepositoryArticle . 2019Data sources: Norwegian Institute of Public Health Open RepositorySpiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 54 citations 54 popularity Top 10% influence Top 10% impulse Top 1% Powered by BIP!visibility 7visibility views 7 download downloads 45 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2019Full-Text: http://europepmc.org/articles/PMC6785228Data sources: PubMed CentralRecolector de Ciencia Abierta, RECOLECTAArticle . 2019Data sources: Recolector de Ciencia Abierta, RECOLECTAEnvironmental Health Perspectives; NARCISArticle . 2019Norwegian Institute of Public Health Open RepositoryArticle . 2019Data sources: Norwegian Institute of Public Health Open RepositorySpiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1289/ehp3971&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2019 France, Spain, France, France, United Kingdom, AustraliaPublisher:Elsevier BV Funded by:NIH | Pilot Project Program, EC | ENRIECO, EC | ESCAPE +2 projectsNIH| Pilot Project Program ,EC| ENRIECO ,EC| ESCAPE ,EC| HELIX ,NIH| Gene-Environment Interactions in an Autism Birth CohortIbon Tamayo-Uria; Léa Maitre; Cathrine Thomsen; Mark J. Nieuwenhuijsen; Leda Chatzi; Valérie Siroux; Gunn Marit Aasvang; Lydiane Agier; Sandra Andrusaityte; Maribel Casas; Montserrat de Castro; Audrius Dedele; Line Småstuen Haug; Barbara Heude; Regina Grazuleviciene; Kristine B. Gutzkow; Norun Hjertager Krog; Dan Mason; Rosemary R. C. McEachan; Helle Margrete Meltzer; Inga Petraviciene; Oliver Robinson; Theano Roumeliotaki; Amrit Kaur Sakhi; Jose Urquiza; Marina Vafeiadi; Dagmar Waiblinger; Charline Warembourg; John Wright; Rémy Slama; Martine Vrijheid; Xavier Basagaña;Characterization of the "exposome", the set of all environmental factors that one is exposed to from conception onwards, has been advocated to better understand the role of environmental factors on chronic diseases. Here, we aimed to describe the early-life exposome. Specifically, we focused on the correlations between multiple environmental exposures, their patterns and their variability across European regions and across time (pregnancy and childhood periods). We relied on the Human Early-Life Exposome (HELIX) project, in which 87 environmental exposures during pregnancy and 122 during the childhood period (grouped in 19 exposure groups) were assessed in 1301 pregnant mothers and their children at 6-11 years in 6 European birth cohorts. Some correlations between exposures in the same exposure group reached high values above 0.8. The median correlation within exposure groups was >0.3 for many exposure groups, reaching 0.69 for water disinfection by products in pregnancy and 0.67 for the meteorological group in childhood. Median correlations between different exposure groups rarely reached 0.3. Some correlations were driven by cohort-level associations (e.g. air pollution and chemicals). Ten principal components explained 45% and 39% of the total variance in the pregnancy and childhood exposome, respectively, while 65 and 90 components were required to explain 95% of the exposome variability. Correlations between maternal (pregnancy) and childhood exposures were high (>0.6) for most exposures modeled at the residential address (e.g. air pollution), but were much lower and even close to zero for some chemical exposures. In conclusion, the early life exposome was high dimensional, meaning that it cannot easily be measured by or reduced to fewer components. Correlations between exposures from different exposure groups were much lower than within exposure groups, which have important implications for co-exposure confounding in multiple exposure studies. Also, we observed the early life exposome to be variable over time and to vary by cohort, so measurements at one time point or one place will not capture its complexities. This work was supported by the European Commission Seventh Framework Programme (FP7/2007–2013) [grant number: 308333–the HELIX project]. INMA data collections were supported by grants from the Instituto de Salud Carlos III, CIBERESP, and the Generalitat de Catalunya-CIRIT. KANC was funded by the grant of the Lithuanian Agency for Science Innovation and Technology (6-04-2014_31V-66). The Norwegian Mother and Child Cohort Study is supported by the Norwegian Ministry of Health and Care Services and the Ministry of Education and Research, NIH/NIEHS (contract no N01-ES-75558), NIH/NINDS (grant no.1 UO1 NS 047537-01 and grant no.2 UO1 NS 047537-06A1). The Rhea project was financially supported by European projects (EU FP6-2003-Food-3-NewGeneris, EU FP6. STREP Hiwate, EU FP7 ENV.2007.1.2.2.2. Project No 211250 Escape, EU FP7-2008-ENV-1.2.1.4 Envirogenomarkers, EU FP7-HEALTH-2009-single stage CHICOS, EU FP7 ENV.2008.1.2.1.6. Proposal No 226285 ENRIECO, EUFP7-HEALTH-2012 Proposal No 308333 HELIX, FP7 European Union project, No. 264357 MeDALL), and the Greek Ministry of Health (Program of Prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece: 2011–2014; “Rhea Plus”: Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012–15).
ACU Research Bank arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; UPF Digital RepositoryArticle . 2019License: CC BY NC NDSpiral - Imperial College Digital RepositoryArticle . 2018Data sources: Spiral - Imperial College Digital RepositoryHAL Descartes; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2019License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 87 citations 87 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 6visibility views 6 download downloads 60 Powered bymore_vert ACU Research Bank arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; UPF Digital RepositoryArticle . 2019License: CC BY NC NDSpiral - Imperial College Digital RepositoryArticle . 2018Data sources: Spiral - Imperial College Digital RepositoryHAL Descartes; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2019License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018 Australia, France, United Kingdom, Netherlands, France, Spain Funded by:NIH | Pilot Project Program, EC | ENRIECO, EC | ESCAPE +1 projectsNIH| Pilot Project Program ,EC| ENRIECO ,EC| ESCAPE ,EC| HELIXAgier, Lydiane; Basagaña Flores, Xavier; Maitre, Lea; Granum, Berit; Bird, Philippa K.; Casas Sanahuja, Maribel; Oftedal, Bente; Wright, John; Andrusaityte, Sandra; de Castro, Montserrat; Cequier Manciñeiras, Enrique; Chatzi, Leda; Donaire Gonzalez, David; Grazuleviciene, Regina; Haug, Line S.; Sakhi, Amrit Kaur; Leventakou, Vasiliki; McEachan, Rosemary; Nieuwenhuijsen, Mark J.; Petraviciene, Inga; Robinson, Oliver; Roumeliotaki, Theano; Sunyer, Jordi; Tamayo-Uria, Ibon; Thomsen, Cathrine; Urquiza, José; Valentín, Antònia; Slama, Rémy; Vrijheid, Martine; Siroux, Valérie;pmid: 32293903
handle: 10459.1/68496
BACKGROUND: Several single-exposure studies have documented possible effects of environmental factors on lung function, but none has relied on an exposome approach. We aimed to evaluate the association between a broad range of prenatal and postnatal lifestyle and environmental exposures and lung function in children.METHODS: In this analysis, we used data from 1033 mother-child pairs from the European Human Early-Life Exposome (HELIX) cohort (consisting of six existing longitudinal birth cohorts in France, Greece, Lithuania, Norway, Spain, and the UK of children born between 2003 and 2009) for whom a valid spirometry test was recorded for the child. 85 prenatal and 125 postnatal exposures relating to outdoor, indoor, chemical, and lifestyle factors were assessed, and lung function was measured by spirometry in children at age 6-12 years. Two agnostic linear regression methods, a deletion-substitution-addition (DSA) algorithm considering all exposures simultaneously, and an exposome-wide association study (ExWAS) considering exposures independently, were applied to test the association with forced expiratory volume in 1 s percent predicted values (FEV1%). We tested for two-way interaction between exposures and corrected for confounding by co-exposures.FINDINGS: In the 1033 children (median age 8·1 years, IQR 6·5-9·0), mean FEV1% was 98·8% (SD 13·2). In the ExWAS, prenatal perfluorononanoate (p=0·034) and perfluorooctanoate (p=0·030) exposures were associated with lower FEV1%, and inverse distance to nearest road during pregnancy (p=0·030) was associated with higher FEV1%. Nine postnatal exposures were associated with lower FEV1%: copper (p=0·041), ethyl-paraben (p=0·029), five phthalate metabolites (mono-2-ethyl 5-carboxypentyl phthalate [p=0·016], mono-2-ethyl-5-hydroxyhexyl phthalate [p=0·023], mono-2-ethyl-5-oxohexyl phthalate [p=0·0085], mono-4-methyl-7-oxooctyl phthalate [p=0·040], and the sum of di-ethylhexyl phthalate metabolites [p=0·014]), house crowding (p=0·015), and facility density around schools (p=0·027). However, no exposure passed the significance threshold when corrected for multiple testing in ExWAS, and none was selected with the DSA algorithm, including when testing for exposure interactions.INTERPRETATION: Our systematic exposome approach identified several environmental exposures, mainly chemicals, that might be associated with lung function. Reducing exposure to these ubiquitous chemicals could help to prevent the development of chronic respiratory disease.FUNDING: European Community's Seventh Framework Programme (HELIX project).
ACU Research Bank arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2019License: CC BY NC NDData sources: Recolector de Ciencia Abierta, RECOLECTASpiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital RepositoryNARCIS; The Lancet Planetary HealthArticle . 2019HAL-Inserm; Hal-DiderotArticle . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert ACU Research Bank arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2019License: CC BY NC NDData sources: Recolector de Ciencia Abierta, RECOLECTASpiral - Imperial College Digital RepositoryArticle . 2019Data sources: Spiral - Imperial College Digital RepositoryNARCIS; The Lancet Planetary HealthArticle . 2019HAL-Inserm; Hal-DiderotArticle . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018Embargo end date: 01 Jan 2018 Switzerland, United Kingdom, Austria EnglishPublisher:ETH Zurich Funded by:EC | CD-LINKS, EC | CRESCENDOEC| CD-LINKS ,EC| CRESCENDOAuthors: Mengel, Matthias; Nauels, Alexander; Rogelj, Joeri; Schleussner, Carl-Friedrich;Mengel, Matthias; Nauels, Alexander; Rogelj, Joeri; Schleussner, Carl-Friedrich;Sea-level rise is a major consequence of climate change that will continue long after emissions of greenhouse gases have stopped. The 2015 Paris Agreement aims at reducing climate-related risks by reducing greenhouse gas emissions to net zero and limiting global-mean temperature increase. Here we quantify the effect of these constraints on global sea-level rise until 2300, including Antarctic ice-sheet instabilities. We estimate median sea-level rise between 0.7 and 1.2 m, if net-zero greenhouse gas emissions are sustained until 2300, varying with the pathway of emissions during this century. Temperature stabilization below 2 °C is insufficient to hold median sea-level rise until 2300 below 1.5 m. We find that each 5-year delay in near-term peaking of CO2 emissions increases median year 2300 sea-level rise estimates by ca. 0.2 m, and extreme sea-level rise estimates at the 95th percentile by up to 1 m. Our results underline the importance of near-term mitigation action for limiting long-term sea-level rise risks. Nature Communications, 9 (1) ISSN:2041-1723
Nature Communication... arrow_drop_down Europe PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC5820313Data sources: PubMed CentralSpiral - Imperial College Digital RepositoryArticle . 2018Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 10 citations 10 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 17visibility views 17 download downloads 23 Powered bymore_vert Nature Communication... arrow_drop_down Europe PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC5820313Data sources: PubMed CentralSpiral - Imperial College Digital RepositoryArticle . 2018Data sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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